Using epigenetic networks for the analysis of movement associated with levodopa therapy for Parkinson's disease

Turner, Alexander P.; Lones, Michael A.; Trefzer, Martin A.; Smith, Stephen L.; Jamieson, Stuart; Alty, Jane E.; Cosgrove, Jeremy; Tyrrell, Andy M.

Abstract

© 2016 The Author(s) Levodopa is a drug that is commonly used to treat movement disorders associated with Parkinson's disease. Its dosage requires careful monitoring, since the required amount changes over time, and excess dosage can lead to muscle spasms known as levodopa-induced dyskinesia. In this work, we investigate the potential for using epiNet, a novel artificial gene regulatory network, as a classifier for monitoring accelerometry time series data collected from patients undergoing levodopa therapy. We also consider how dynamical analysis of epiNet classifiers and their transitions between different states can highlight clinically useful information which is not available through more conventional data mining techniques. The results show that epiNet is capable of discriminating between different movement patterns which are indicative of either insufficient or excessive levodopa.

Citation

Turner, A. P., Lones, M. A., Trefzer, M. A., Smith, S. L., Jamieson, S., Alty, J. E., Cosgrove, J., & Tyrrell, A. M. (2016). Using epigenetic networks for the analysis of movement associated with levodopa therapy for Parkinson's disease. BioSystems, 146, 35-42. https://doi.org/10.1016/j.biosystems.2016.05.005

• Journal Article Type: Article
• Acceptance Date: May 10, 2016
• Online Publication Date: Jun 24, 2016
• Publication Date: 2016-08
• Deposit Date: Feb 14, 2017
• Publicly Available Date: Feb 14, 2017
• Journal: Biosystems
• Print ISSN: 0303-2647
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 146
• Pages: 35-42
• DOI: https://doi.org/10.1016/j.biosystems.2016.05.005
• Keywords: Epigenetics, Artificial gene regulatory networks, EpiNet, Classification, Parkinson's disease
• Public URL: https://hull-repository.worktribe.com/output/448337
• Publisher URL: http://www.sciencedirect.com/science/article/pii/S0303264716300582
• Additional Information: This article is maintained by: Elsevier; Article Title: Using epigenetic networks for the analysis of movement associated with levodopa therapy for Parkinson's disease; Journal Title: Biosystems; CrossRef DOI link to publisher maintained version: http://dx.doi.org/10.1016/j.biosystems.2016.05.005; Content Type: article; Copyright: © 2016 The Author(s). Published by Elsevier Ireland Ltd.
• Contract Date: Feb 14, 2017