Real-world experience of nintedanib for progressive fibrosing interstitial lung disease in the UK

Dixon, Giles; Hague, Samuel; Mulholland, Sarah; Adamali, Huzaifa; Khin, Aye Myat Noe; Thould, Hannah; Connon, Roisin; Minnis, Paul; Murtagh, Eoin; Khan, Fasihul; Toor, Sameen; Lawrence, Alexandra; Naqvi, Marium; West, Alex; Coker, Robina K.; Ward, Katie; Yazbeck, Leda; Hart, Simon; Garfoot, Theresa; Newman, Kate; Rivera-Ortega, Pilar; Stranks, Lachlan; Beirne, Paul; Bradley, Jessica; Rowan, Catherine; Agnew, Sarah; Ahmad, Mahin; Spencer, Lisa G.; Aigbirior, Joshua; Fahim, Ahmed; Wilson, Andrew M.; Butcher, Elizabeth; Chong, Sy Giin; Saini, Gauri; Zulfikar, Sabrina; Chua, Felix; George, Peter M.; Kokosi, Maria; Kouranos, Vasileios; Molyneaux, Philip; Renzoni, Elisabetta; Vitri, Benedetta; Wells, Athol U.; Nicol, Lisa M.; Bianchi, Stephen; Kular, Raman; Liu, Huajian; John, Alexander; Barth, Sarah; Wickremasinghe, Melissa; Forrest, Ian A.; Grimes, Ian; Simpson, A. John; Fletcher, Sophie V.; Jones, Mark G.; Kinsella, Emma; Naftel, Jennifer; Wood, Nicola; Chalmers, Jodie; Crawshaw, Anjali;...

Abstract

Background Nintedanib slows progression of lung function decline in patients with progressive fibrosing (PF) interstitial lung disease (ILD) and was recommended for this indication within the United Kingdom (UK) National Health Service in Scotland in June 2021 and in England, Wales and Northern Ireland in November 2021. To date, there has been no national evaluation of the use of nintedanib for PF-ILD in a real-world setting. Methods 26 UK centres were invited to take part in a national service evaluation between 17 November 2021 and 30 September 2022. Summary data regarding underlying diagnosis, pulmonary function tests, diagnostic criteria, radiological appearance, concurrent immunosuppressive therapy and drug tolerability were collected via electronic survey. Results 24 UK prescribing centres responded to the service evaluation invitation. Between 17 November 2021 and 30 September 2022, 1120 patients received a multidisciplinary team recommendation to commence nintedanib for PF-ILD. The most common underlying diagnoses were hypersensitivity pneumonitis (298 out of 1120, 26.6%), connective tissue disease associated ILD (197 out of 1120, 17.6%), rheumatoid arthritis associated ILD (180 out of 1120, 16.0%), idiopathic nonspecific interstitial pneumonia (125 out of 1120, 11.1%) and unclassifiable ILD (100 out of 1120, 8.9%). Of these, 54.4% (609 out of 1120) were receiving concomitant corticosteroids, 355 (31.7%) out of 1120 were receiving concomitant mycophenolate mofetil and 340 (30.3%) out of 1120 were receiving another immunosuppressive/ modulatory therapy. Radiological progression of ILD combined with worsening respiratory symptoms was the most common reason for the diagnosis of PF-ILD. Conclusion We have demonstrated the use of nintedanib for the treatment of PF-ILD across a broad range of underlying conditions. Nintedanib is frequently co-prescribed alongside immunosuppressive and immunomodulatory therapy. The use of nintedanib for the treatment of PF-ILD has demonstrated acceptable tolerability in a real-world setting.

Citation

Dixon, G., Hague, S., Mulholland, S., Adamali, H., Khin, A. M. N., Thould, H., Connon, R., Minnis, P., Murtagh, E., Khan, F., Toor, S., Lawrence, A., Naqvi, M., West, A., Coker, R. K., Ward, K., Yazbeck, L., Hart, S., Garfoot, T., Newman, K., …Barratt, S. L. (2024). Real-world experience of nintedanib for progressive fibrosing interstitial lung disease in the UK. ERJ Open Research, 10(1), Article 00529-2023. https://doi.org/10.1183/23120541.00529-2023

• Journal Article Type: Article
• Acceptance Date: Oct 17, 2023
• Online Publication Date: Jan 15, 2024
• Publication Date: Jan 1, 2024
• Deposit Date: Jan 23, 2024
• Publicly Available Date: Jan 25, 2024
• Journal: ERJ Open Research
• Electronic ISSN: 2312-0541
• Publisher: European Respiratory Society
• Peer Reviewed: Peer Reviewed
• Volume: 10
• Issue: 1
• Article Number: 00529-2023
• DOI: https://doi.org/10.1183/23120541.00529-2023
• Keywords: Pulmonary and Respiratory Medicine
• Public URL: https://hull-repository.worktribe.com/output/4523213