Skip to main content

Effect of soy on bone turn-over markers in men with type 2 diabetes and hypogonadism - A randomised controlled study

Sathyapalan, T.; Aye, M.; Rigby, A. S.; Fraser, W. D.; Kilpatrick, E. S.; Atkin, S. L.

Authors

T. Sathyapalan

M. Aye

A. S. Rigby

W. D. Fraser

E. S. Kilpatrick

S. L. Atkin



Abstract

© 2017 The Author(s). Type 2 diabetes (T2DM) is associated with increased risk of fractures. Soy supplementation has been shown to have a beneficial effect on bone turnover markers (BTM) in postmenopausal women. However, the effect of soy supplementation on BTM in T2DM and particularly in men is unclear. We performed an analysis of a randomized double blind parallel study of 200 men with T2DM treated with soy, either with or without isoflavones. Outcome measures were type I collagen crosslinked beta C-telopeptide (βCTX), and type 1 procollagen-N-propeptide (P1NP). The men, with a total testosterone < 12 nmol/L, were treated with 15 g soy protein containing 66 mg of isoflavones (SPI) or 15 g soy protein alone without isoflavones (SP) daily for three months. There was a 15% reduction in βCTX after three months of SPI compared to SP supplementation. There was no significant difference in P1NP with either SPI or SP supplementation. There was a significant linear correlation between the reduction in βCTX in the SPI group with the reduction in HbA1c (r 2 = 0.42; p = 0.04) and HOMA-IR (r 2 = 0.54; p = 0.02). Our study indicates that there was a significant reduction in bone resorption following 3 months of SPI supplementation that correlated with an improvement of glycemic control in men with T2DM.

Journal Article Type Article
Publication Date Nov 13, 2017
Journal Scientific reports
Print ISSN 2045-2322
Electronic ISSN 2045-2322
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 7
Issue 1
Article Number ARTN 15366
APA6 Citation Sathyapalan, T., Aye, M., Rigby, A. S., Fraser, W. D., Kilpatrick, E. S., & Atkin, S. L. (2017). Effect of soy on bone turn-over markers in men with type 2 diabetes and hypogonadism - A randomised controlled study. Scientific reports, 7(1), https://doi.org/10.1038/s41598-017-15402-9
DOI https://doi.org/10.1038/s41598-017-15402-9
Keywords Type 2 diabetes, Bone turnover markers, Isoflavones, Hypogonadism, Soy
Publisher URL https://www.nature.com/articles/s41598-017-15402-9
Copyright Statement Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Additional Information This is the author's accepted manuscript of an article accepted for publication in Scientific reports.

Files

Article (195 Kb)
PDF

Copyright Statement
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.





Downloadable Citations