Robert Howard
Adapted problem adaptation therapy for depression in mild to moderate Alzheimer's disease dementia: A randomized controlled trial
Howard, Robert; Cort, Elizabeth; Rawlinson, Charlotte; Wiegand, Martin; Downey, Anne; Lawrence, Vanessa; Banerjee, Sube; Bentham, Peter; Fox, Chris; Harwood, Rowan; Hunter, Rachel; Livingston, Gill; Moniz-Cook, Esme; Panca, Monica; Raczek, Malgorzata; Ivenso, Chineze; Russell, Gregor; Thomas, Alan; Wilkinson, Philip; Freemantle, Nicholas; Gould, Rebecca
Authors
Elizabeth Cort
Charlotte Rawlinson
Martin Wiegand
Anne Downey
Vanessa Lawrence
Sube Banerjee
Peter Bentham
Chris Fox
Rowan Harwood
Rachel Hunter
Gill Livingston
Professor Esme Moniz-Cook E.D.Moniz-Cook@hull.ac.uk
Emeritus Professor of Clinical Psychology of Ageing and Dementia Care Research / Dementia Research Work Group Lead
Monica Panca
Malgorzata Raczek
Chineze Ivenso
Gregor Russell
Alan Thomas
Philip Wilkinson
Nicholas Freemantle
Rebecca Gould
Abstract
INTRODUCTION: Trials of effectiveness of treatment options for depression in dementia are an important priority. METHODS: Randomized controlled trial to assess adapted Problem Adaptation Therapy (PATH) for depression in mild/moderate dementia caused by Alzheimer's disease. RESULTS: Three hundred thirty-six participants with mild or moderate dementia, >7 on Cornell Scale for Depression in Dementia (CSDD), randomized to adapted PATH or treatment as usual. Mean age 77.0years, 39.0% males, mean Mini-Mental State Examination 21.6, mean CSDD 12.9. For primary outcome (CSDD at 6 months), no statistically significant benefit with adapted PATH on the CSDD (6 months: −0.58; 95% CI −1.71 to 0.54). The CSDD at 3 months showed a small benefit with adapted PATH (−1.38; 95% CI −2.54 to −0.21) as did the EQ-5D (−4.97; 95% CI −9.46 to −0.48). DISCUSSION: An eight-session course of adapted PATH plus two booster sessions administered within NHS dementia services was not effective treatment for depression in people with mild and moderate dementia. Future studies should examine the effect of more intensive and longer-term therapy.
Citation
Howard, R., Cort, E., Rawlinson, C., Wiegand, M., Downey, A., Lawrence, V., …Gould, R. (2024). Adapted problem adaptation therapy for depression in mild to moderate Alzheimer's disease dementia: A randomized controlled trial. Alzheimer's & dementia, https://doi.org/10.1002/alz.13766
Journal Article Type | Article |
---|---|
Acceptance Date | Feb 2, 2024 |
Online Publication Date | Mar 13, 2024 |
Publication Date | 2024 |
Deposit Date | Mar 13, 2024 |
Publicly Available Date | Mar 15, 2024 |
Journal | Alzheimer's and Dementia |
Print ISSN | 1552-5260 |
Electronic ISSN | 1552-5279 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
DOI | https://doi.org/10.1002/alz.13766 |
Keywords | Alzheimer's disease; Clinical trial; Depression; Mood; Problem adaptation therapy; Psychological; Psychotherapy |
Public URL | https://hull-repository.worktribe.com/output/4589100 |
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Copyright Statement
© 2024 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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