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Adapted problem adaptation therapy for depression in mild to moderate Alzheimer's disease dementia: A randomized controlled trial

Howard, Robert; Cort, Elizabeth; Rawlinson, Charlotte; Wiegand, Martin; Downey, Anne; Lawrence, Vanessa; Banerjee, Sube; Bentham, Peter; Fox, Chris; Harwood, Rowan; Hunter, Rachel; Livingston, Gill; Moniz-Cook, Esme; Panca, Monica; Raczek, Malgorzata; Ivenso, Chineze; Russell, Gregor; Thomas, Alan; Wilkinson, Philip; Freemantle, Nicholas; Gould, Rebecca

Authors

Robert Howard

Elizabeth Cort

Charlotte Rawlinson

Martin Wiegand

Anne Downey

Vanessa Lawrence

Sube Banerjee

Peter Bentham

Chris Fox

Rowan Harwood

Rachel Hunter

Gill Livingston

Profile image of Esme Moniz-Cook

Professor Esme Moniz-Cook E.D.Moniz-Cook@hull.ac.uk
Emeritus Professor of Clinical Psychology of Ageing and Dementia Care Research / Dementia Research Work Group Lead

Monica Panca

Malgorzata Raczek

Chineze Ivenso

Gregor Russell

Alan Thomas

Philip Wilkinson

Nicholas Freemantle

Rebecca Gould



Abstract

INTRODUCTION: Trials of effectiveness of treatment options for depression in dementia are an important priority. METHODS: Randomized controlled trial to assess adapted Problem Adaptation Therapy (PATH) for depression in mild/moderate dementia caused by Alzheimer's disease. RESULTS: Three hundred thirty-six participants with mild or moderate dementia, >7 on Cornell Scale for Depression in Dementia (CSDD), randomized to adapted PATH or treatment as usual. Mean age 77.0years, 39.0% males, mean Mini-Mental State Examination 21.6, mean CSDD 12.9. For primary outcome (CSDD at 6 months), no statistically significant benefit with adapted PATH on the CSDD (6 months: −0.58; 95% CI −1.71 to 0.54). The CSDD at 3 months showed a small benefit with adapted PATH (−1.38; 95% CI −2.54 to −0.21) as did the EQ-5D (−4.97; 95% CI −9.46 to −0.48). DISCUSSION: An eight-session course of adapted PATH plus two booster sessions administered within NHS dementia services was not effective treatment for depression in people with mild and moderate dementia. Future studies should examine the effect of more intensive and longer-term therapy.

Citation

Howard, R., Cort, E., Rawlinson, C., Wiegand, M., Downey, A., Lawrence, V., …Gould, R. (2024). Adapted problem adaptation therapy for depression in mild to moderate Alzheimer's disease dementia: A randomized controlled trial. Alzheimer's & dementia, https://doi.org/10.1002/alz.13766

Journal Article Type Article
Acceptance Date Feb 2, 2024
Online Publication Date Mar 13, 2024
Publication Date 2024
Deposit Date Mar 13, 2024
Publicly Available Date Mar 15, 2024
Journal Alzheimer's and Dementia
Print ISSN 1552-5260
Electronic ISSN 1552-5279
Publisher Elsevier
Peer Reviewed Peer Reviewed
DOI https://doi.org/10.1002/alz.13766
Keywords Alzheimer's disease; Clinical trial; Depression; Mood; Problem adaptation therapy; Psychological; Psychotherapy
Public URL https://hull-repository.worktribe.com/output/4589100

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Publisher Licence URL
http://creativecommons.org/licenses/by/4.0

Copyright Statement
© 2024 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.




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