Effectiveness of mindfulness-based stress reduction in mood, breast- and endocrine-related quality of life, and well-being in stage 0 to III breast cancer : a randomized, controlled trial

Hoffman, Caroline J.; Ersser, Steven J.; Hopkinson, Jane B.; Nicholls, Peter G.; Harrington, Julia E.; Thomas, Peter W.

Abstract

Purpose To assess the effectiveness of mindfulness-based stress reduction (MBSR) for mood, breast- and endocrine-specific quality of life, and well-being after hospital treatment in women with stage 0 to III breast cancer. Patients and Methods A randomized, wait-listed, controlled trial was carried out in 229 women after surgery, chemotherapy, and radiotherapy for breast cancer. Patients were randomly assigned to the 8-week MBSR program or standard care. Profile of Mood States (POMS; primary outcome), Functional Assessment of Cancer Therapy–Breast (FACT-B), Functional Assessment of Cancer Therapy–Endocrine Symptoms (FACT-ES) scales and the WHO five-item well-being questionnaire (WHO-5) evaluated mood, quality of life, and well-being at weeks 0, 8, and 12. For each outcome measure, a repeated-measures analysis of variance model, which incorporated week 0 measurements as a covariate, was used to compare treatment groups at 8 and 12 weeks. Results There were statistically significant improvements in outcome in the experimental group compared with control group at both 8 and 12 weeks (except as indicated) for POMS total mood disturbance (and its subscales of anxiety, depression [8 weeks only], anger [12 weeks only], vigor, fatigue, and confusion [8 weeks only]), FACT-B, FACT-ES, (and Functional Assessment of Cancer Therapy subscales of physical, social [8 weeks only], emotional, and functional well-being), and WHO-5. Conclusion MSBR improved mood, breast- and endocrine-related quality of life, and well-being more effectively than standard care in women with stage 0 to III breast cancer, and these results persisted at three months. To our knowledge, this study provided novel evidence that MBSR can help alleviate long-term emotional and physical adverse effects of medical treatments, including endocrine treatments. MBSR is recommended to support survivors of breast cancer.

Citation

Hoffman, C. J., Ersser, S. J., Hopkinson, J. B., Nicholls, P. G., Harrington, J. E., & Thomas, P. W. (2012). Effectiveness of mindfulness-based stress reduction in mood, breast- and endocrine-related quality of life, and well-being in stage 0 to III breast cancer : a randomized, controlled trial. Journal of Clinical Oncology, 30(12), 1335-1342. https://doi.org/10.1200/jco.2010.34.0331

• Journal Article Type: Article
• Acceptance Date: Feb 1, 2011
• Publication Date: Apr 20, 2012
• Deposit Date: Nov 13, 2014
• Publicly Available Date: Nov 13, 2014
• Journal: Journal of clinical oncology
• Print ISSN: 0732-183X
• Electronic ISSN: 1527-7755
• Publisher: American Society of Clinical Oncology
• Peer Reviewed: Peer Reviewed
• Volume: 30
• Issue: 12
• Pages: 1335-1342
• DOI: https://doi.org/10.1200/jco.2010.34.0331
• Keywords: REF 2014 submission
• Public URL: https://hull-repository.worktribe.com/output/465490
• Publisher URL: http://ascopubs.org/doi/full/10.1200/JCO.2010.34.0331
• Additional Information: Copy of article: Effectiveness of Mindfulness-Based Stress Reduction in Mood, Breast- and Endocrine-Related Quality of Life, and Well-Being in stage 0 to III Breast Cancer: A Randomized, Controlled Trial. Caroline J. Hoffman, Steven J. Ersser, Jane B. Hopkinson, Peter G. Nicholls, Julia E. Harrington, Peter W. Thomas Caroline J. Hoffman and Julia E. Harrington, The Haven, London; Steven J. Ersser, University of Hull, Hull; Jane B. Hopkinson, Cardiff University, Cardiff; Peter G. Nicholls, University of Southampton, Southampton; Peter W. Thomas, Bournemouth University, Bournemouth, United Kingdom. Journal of Clinical Oncology 2012 30:12, 1335-1342