Advancements in the management of obesity: a review of current evidence and emerging therapies

Abdalla Ahmed, Mohammed Altigani; Ssemmondo, Emmanuel; Mark-Wagstaff, Charlotte; Sathyapalan, Thozhukat

Abstract

Introduction: Obesity is the modern world’s current epidemic, with substantial health and economic impact. This study aimed to provide a narrative overview of the past, currently available, and future treatment options that offer therapeutic and preventive advantages for obesity management. Areas covered: Historically, rimonabant, and lorcaserin, were approved and used for managing non-syndromic obesity. Currently, orlistat, naltrexone/bupropion, glucagon-like peptide-1 receptor agonist (GLP-1 RA), and a few promising therapeutic agents are under investigation, including retatrutide, cagrilintide and orforglipron, which show promising weight reduction effects. We have developed a search string of the Medical Subject Headings (MeSH), including the terms GLP-1 RAs, obesity, and weight loss. This string was then used to perform a systematic literature search in the database including PubMed, EMBASE, MEDLINE, and Scopus up to January 31st, 2024. Expert opinion: Managing obesity often requires medical interventions, particularly in cases of severe obesity or obesity-related comorbidities. Thus, it is important to approach obesity management holistically, considering individual needs and circumstances. In our opinion, consulting with healthcare professionals is crucial to developing a personalized plan that addresses both weight loss and overall health improvement.

Citation

Abdalla Ahmed, M. A., Ssemmondo, E., Mark-Wagstaff, C., & Sathyapalan, T. (2024). Advancements in the management of obesity: a review of current evidence and emerging therapies. Expert Review of Endocrinology and Metabolism, 19(3), 257-268. https://doi.org/10.1080/17446651.2024.2347258

• Journal Article Type: Review
• Acceptance Date: Apr 22, 2024
• Online Publication Date: Apr 29, 2024
• Publication Date: Jan 1, 2024
• Deposit Date: Sep 9, 2024
• Publicly Available Date: Jan 2, 2025
• Journal: Expert Review of Endocrinology and Metabolism
• Print ISSN: 1744-6651
• Electronic ISSN: 1744-8417
• Publisher: Taylor and Francis Group
• Peer Reviewed: Peer Reviewed
• Volume: 19
• Issue: 3
• Pages: 257-268
• DOI: https://doi.org/10.1080/17446651.2024.2347258
• Keywords: Obesity; Diabesity; GLP-1 RA; Overweight; Pharmacotherapy
• Public URL: https://hull-repository.worktribe.com/output/4664229