Cellular uptake of a fluorescent calix[4]arene derivative

Matthews, Susan E.; Redshaw, Carl; Baillie-Johnson, Hugo; Lalor, Ruth; Mueller, Anja

Abstract

A rapid synthetic route to a nontoxic fluorescently labeled water-soluble calixarene has been developed. Investigation of the cellular uptake of the labeled calixarene, via confocal microscopy, through coincubation with uptake inhibitors demonstrates that uptake is not through the common clathrin coated pits or caveolae (lipid raft) endocytic pathways and that the calixarene derivative localizes within the cytoplasm and does not enter the nucleus. The study demonstrates the power of fluorescent labeling for investigation of interactions between calixarenes and biological systems and the potential for calixarene based intracellular imaging agents. Copyright © 2008 American Chemical Society.

Citation

Matthews, S. E., Redshaw, C., Baillie-Johnson, H., Lalor, R., & Mueller, A. (2008). Cellular uptake of a fluorescent calix[4]arene derivative. Journal of the American Chemical Society, 130(10), 2892-2893. https://doi.org/10.1021/ja0782596

• Journal Article Type: Article
• Acceptance Date: Oct 29, 2007
• Online Publication Date: Feb 16, 2008
• Publication Date: Mar 12, 2008
• Deposit Date: Nov 13, 2014
• Journal: Journal Of The American Chemical Society
• Print ISSN: 0002-7863
• Publisher: American Chemical Society
• Peer Reviewed: Peer Reviewed
• Volume: 130
• Issue: 10
• Pages: 2892-2893
• DOI: https://doi.org/10.1021/ja0782596
• Keywords: Colloid and Surface Chemistry; Biochemistry; General Chemistry; Catalysis
• Public URL: https://hull-repository.worktribe.com/output/468213
• Contract Date: Nov 13, 2014