Benedetta Armocida
Burden of non-communicable diseases among adolescents aged 10–24 years in the EU, 1990–2019: a systematic analysis of the Global Burden of Diseases Study 2019
Armocida, Benedetta; Monasta, Lorenzo; Sawyer, Susan; Bustreo, Flavia; Segafredo, Giulia; Castelpietra, Giulio; Ronfani, Luca; Pasovic, Maja; Hay, Simon; Abila, Derrick Bary; Abolhassani, Hassan; Accrombessi, Manfred Mario Kokou; Adekanmbi, Victor; Ahmadi, Keivan; Al Hamad, Hanadi; Aldeyab, Mamoon A.; Al-Jumaily, Adel; Ancuceanu, Robert; Andrei, Catalina Liliana; Andrei, Tudorel; Arumugam, Ashokan; Attia, Sameh; Aujayeb, Avinash; Ausloos, Marcel; Baker, Jennifer L.; Barone-Adesi, Francesco; Barra, Fabio; Barteit, Sandra; Basu, Sanjay; Baune, Bernhard T.; Béjot, Yannick; Belo, Luis; Bennett, Derrick A.; Bikbov, Boris; Bikov, Andras; Blyuss, Oleg; Breitner, Susanne; Brenner, Hermann; Carreras, Giulia; Carvalho, Márcia; Catapano, Alberico L.; Chandan, Joht Singh; Charalampous, Periklis; Chen, Simiao; Conde, Joao; Cruz-Martins, Natália; Damiani, Giovanni; Dastiridou, Anna; de la Torre-Luque, Alejandro; Dianatinasab, Mostafa; Dias da Silva, Diana; Douiri, Abdel; Dragioti, Elena; Engelbert B...
Authors
Lorenzo Monasta
Susan Sawyer
Flavia Bustreo
Giulia Segafredo
Giulio Castelpietra
Luca Ronfani
Maja Pasovic
Simon Hay
Derrick Bary Abila
Hassan Abolhassani
Manfred Mario Kokou Accrombessi
Victor Adekanmbi
Keivan Ahmadi
Hanadi Al Hamad
Mamoon A. Aldeyab
Adel Al-Jumaily
Robert Ancuceanu
Catalina Liliana Andrei
Tudorel Andrei
Ashokan Arumugam
Sameh Attia
Avinash Aujayeb
Marcel Ausloos
Jennifer L. Baker
Francesco Barone-Adesi
Fabio Barra
Sandra Barteit
Sanjay Basu
Bernhard T. Baune
Yannick Béjot
Luis Belo
Derrick A. Bennett
Boris Bikbov
Andras Bikov
Oleg Blyuss
Susanne Breitner
Hermann Brenner
Giulia Carreras
Márcia Carvalho
Alberico L. Catapano
Joht Singh Chandan
Periklis Charalampous
Simiao Chen
Joao Conde
Natália Cruz-Martins
Giovanni Damiani
Anna Dastiridou
Alejandro de la Torre-Luque
Mostafa Dianatinasab
Diana Dias da Silva
Abdel Douiri
Elena Dragioti
Luchuo Engelbert Bain
Adeniyi Francis Fagbamigbe
Seyed Mohammad Fereshtehnejad
Pietro Ferrara
José Miguel P. Ferreira de Oliveira
Simone Ferrero
Lorenzo Ferro Desideri
Florian Fischer
Diogo A. Fonseca
Piyada Gaewkhiew
Santosh Gaihre
Silvano Gallus
Mariana Gaspar Fonseca
Paramjit Singh Gill
James C. Glasbey
Giuseppe Gorini
Vijai Kumar Gupta
Mekdes Kondale Gurara
Josep Maria Haro
M. Tasdik Hasan
Rasmus J. Havmoeller
Behzad Heibati
Merel E. Hellemons
Claudiu Herteliu
Salman Hussain
Gaetano Isola
Olatunji Johnson
Jost B. Jonas
Jacek Jerzy Jozwiak
Mikk Jürisson
Zubair Kabir
André Karch
Joonas H. Kauppila
Gbenga A. Kayode
Moien AB Khan
Khaled Khatab
Mika Kivimäki
Miloslav Klugar
Jitka Klugarová
Kamrun Nahar Koly
Ai Koyanagi
Om P. Kurmi
Dian Kusuma
Carlo La Vecchia
Ben Lacey
Tea Lallukka
Dr Ireneous Soyiri I.N.Soyiri@hull.ac.uk
Senior Lecturer in Epidemiology
Abstract
Background: Disability and mortality burden of non-communicable diseases (NCDs) have risen worldwide; however, the NCD burden among adolescents remains poorly described in the EU. Methods: Estimates were retrieved from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. Causes of NCDs were analysed at three different levels of the GBD 2019 hierarchy, for which mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) were extracted. Estimates, with the 95% uncertainty intervals (UI), were retrieved for EU Member States from 1990 to 2019, three age subgroups (10–14 years, 15–19 years, and 20–24 years), and by sex. Spearman's correlation was conducted between DALY rates for NCDs and the Socio-demographic Index (SDI) of each EU Member State. Findings: In 2019, NCDs accounted for 86·4% (95% uncertainty interval 83·5–88·8) of all YLDs and 38·8% (37·4–39·8) of total deaths in adolescents aged 10–24 years. For NCDs in this age group, neoplasms were the leading causes of both mortality (4·01 [95% uncertainty interval 3·62–4·25] per 100 000 population) and YLLs (281·78 [254·25–298·92] per 100 000 population), whereas mental disorders were the leading cause for YLDs (2039·36 [1432·56–2773·47] per 100 000 population) and DALYs (2040·59 [1433·96–2774·62] per 100 000 population) in all EU Member States, and in all studied age groups. In 2019, among adolescents aged 10–24 years, males had a higher mortality rate per 100 000 population due to NCDs than females (11·66 [11·04–12·28] vs 7·89 [7·53–8·23]), whereas females presented a higher DALY rate per 100 000 population due to NCDs (8003·25 [5812·78–10 701·59] vs 6083·91 [4576·63–7857·92]). From 1990 to 2019, mortality rate due to NCDs in adolescents aged 10–24 years substantially decreased (–40·41% [–43·00 to –37·61), and also the YLL rate considerably decreased (–40·56% [–43·16 to –37·74]), except for mental disorders (which increased by 32·18% [1·67 to 66·49]), whereas the YLD rate increased slightly (1·44% [0·09 to 2·79]). Positive correlations were observed between DALY rates and SDIs for substance use disorders (rs=0·58, p=0·0012) and skin and subcutaneous diseases (rs=0·45, p=0·017), whereas negative correlations were found between DALY rates and SDIs for cardiovascular diseases (rs=–0·46, p=0·015), neoplasms (rs=–0·57, p=0·0015), and sense organ diseases (rs=–0·61, p=0·0005). Interpretation: NCD-related mortality has substantially declined among adolescents in the EU between 1990 and 2019, but the rising trend of YLL attributed to mental disorders and their YLD burden are concerning. Differences by sex, age group, and across EU Member States highlight the importance of preventive interventions and scaling up adolescent-responsive health-care systems, which should prioritise specific needs by sex, age, and location. Funding: Bill & Melinda Gates Foundation.
Citation
Armocida, B., Monasta, L., Sawyer, S., Bustreo, F., Segafredo, G., Castelpietra, G., …Soyiri, I. (2022). Burden of non-communicable diseases among adolescents aged 10–24 years in the EU, 1990–2019: a systematic analysis of the Global Burden of Diseases Study 2019. The Lancet Child & Adolescent Health, 6(6), 367-383. https://doi.org/10.1016/S2352-4642%2822%2900073-6
Journal Article Type | Article |
---|---|
Acceptance Date | Mar 24, 2022 |
Online Publication Date | Mar 24, 2022 |
Publication Date | Jun 1, 2022 |
Deposit Date | Jun 20, 2024 |
Publicly Available Date | Jun 28, 2024 |
Journal | The Lancet Child and Adolescent Health |
Electronic ISSN | 2352-4642 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 6 |
Issue | 6 |
Pages | 367-383 |
DOI | https://doi.org/10.1016/S2352-4642%2822%2900073-6 |
Public URL | https://hull-repository.worktribe.com/output/4713832 |
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Copyright Statement
Copyright © 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.
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