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Aggregation-Induced Emission Photosensitizer with Ag(I)−π Interaction-Enhanced Reactive Oxygen Species for Eliminating Multidrug Resistant Bacteria

Peng, Senlin; Song, Jiayi; Wu, Shouting; Wang, Qian; Shen, Lingyi; Li, Dongmei; Peng, Jian; Zhang, Qilong; Yang, Xianjiong; Xu, Hong; Redshaw, Carl; Li, Ying

Authors

Senlin Peng

Jiayi Song

Shouting Wu

Qian Wang

Lingyi Shen

Dongmei Li

Jian Peng

Qilong Zhang

Xianjiong Yang

Hong Xu

Profile Image

Professor Carl Redshaw C.Redshaw@hull.ac.uk
Professor of Inorganic Materials Chemistry and REF Lead for Chemistry

Ying Li



Abstract

Multidrug-resistant (MDR) bacteria pose serious threats to public health due to the lack of effective and biocompatible drugs to kill MDR bacteria. Photodynamic antibacterial therapy has been widely studied due to its low induction of resistance. However, photosensitizers that can efficiently generate reactive oxygen species (ROS) through both type I and type II mechanisms and that have the capability of multiple modes of action are rarely reported. Addressing this issue, we developed a near-infrared-emitting triphenylamine indole iodoethane (TTII) and its silver(I) self-assembled (TTIIS) aggregation-induced emission (AIE) photosensitizer for multimode bacterial infection therapy. TTII can efficiently produce both Type I ROS •OH and Type II ROS 1O2. Interestingly, the Ag(I)−π interaction contributed in TTIIS efficiency promotion of the generation of 1O2. Moreover, by releasing Ag+, TTIIS enabled photodynamic-Ag(I) dual-mode sterilization. As a result, TTIIS achieved an effective enhancement of antibacterial activity, with a 1-2-fold boost against multidrug-resistant Escherichia coli (MDR E. coli). Both TTII and TTIIS at a concentration as low as 0.55 μg mL-1 can kill more than 98% of methicillin resistant Staphylococcus aureus (MRSA) on MRSA-infected full-thickness defect wounds of a mouse, and both TTII and TTIIS were effective in eliminating the bacteria and promoting wound healing.

Citation

Peng, S., Song, J., Wu, S., Wang, Q., Shen, L., Li, D., Peng, J., Zhang, Q., Yang, X., Xu, H., Redshaw, C., & Li, Y. (2024). Aggregation-Induced Emission Photosensitizer with Ag(I)−π Interaction-Enhanced Reactive Oxygen Species for Eliminating Multidrug Resistant Bacteria. ACS Applied Materials & Interfaces, 16(24), 30915-30928. https://doi.org/10.1021/acsami.4c05202

Journal Article Type Article
Acceptance Date May 29, 2024
Online Publication Date Jun 7, 2024
Publication Date Jun 19, 2024
Deposit Date Jun 22, 2024
Publicly Available Date Jun 8, 2025
Journal ACS Applied Materials and Interfaces
Print ISSN 1944-8244
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 16
Issue 24
Pages 30915-30928
DOI https://doi.org/10.1021/acsami.4c05202
Public URL https://hull-repository.worktribe.com/output/4717706