Acceptability and preliminary efficacy of a web-and telephone-based personalised exercise intervention for individuals with metastatic prostate cancer: The exerciseguide pilot randomised controlled trial
Evans, Holly E.L.; Galvão, Daniel A.; Forbes, Cynthia C.; Girard, Danielle; Vandelanotte, Corneel; Newton, Robert U.; Vincent, Andrew D.; Wittert, Gary; Kichenadasse, Ganessan; Chambers, Suzanne; Brook, Nicholas; Short, Camille E.
Preliminary research has shown the effectiveness of supervised exercise-based interventions in alleviating sequela resulting from metastatic prostate cancer. However, many individuals encounter barriers that limit the uptake of face-to-face exercise. Technology-enabled interventions offer a distance-based alternative. This pilot study aimed to explore the acceptability, safety and preliminary efficacy of a web-based exercise intervention (ExerciseGuide) in individuals with metastatic prostate cancer. Forty participants (70.2 ± 8.5 years) with metastatic prostate cancer were randomised into the 8-week intervention (N = 20) or a wait-list control (N = 20). The intervention arm had access to a computer-tailored website, personalised exercise prescription and remote supervision. ExerciseGuide was deemed acceptable with a score ≥20 on the client satisfaction questionnaire; however, the usability score was just below the pre-specified score of ≥68 on the software usability scale. There were no serious adverse events reported. Moderate-to-vigorous physical activity levels between baseline and follow-ups were significantly higher (10.0 min per day; 95% CI = (1.3–18.6); p = 0.01) in the intervention group compared to wait-list control. There were also greater improvements in step count (1332; 95% CI = (159–2505); p = 0.02) and identified motivation (0.4, 95% CI = (0.0, 0.7); p = 0.04). Our findings provide preliminary evidence that ExerciseGuide is acceptable, safe and efficacious among individuals with metastatic prostate cancer.
Citation
Evans, H. E., Galvão, D. A., Forbes, C. C., Girard, D., Vandelanotte, C., Newton, R. U., Vincent, A. D., Wittert, G., Kichenadasse, G., Chambers, S., Brook, N., & Short, C. E. (2021). Acceptability and preliminary efficacy of a web-and telephone-based personalised exercise intervention for individuals with metastatic prostate cancer: The exerciseguide pilot randomised controlled trial. Cancers, 13(23), Article 5925. https://doi.org/10.3390/cancers13235925
