Microfluidic-based 3D bioprinting to fabricate blood vasculature

Moetazedian, Amirpasha; Cox, Liam; Grover, Liam; Poologasundarampillai, Gowsihan

Abstract

Introduction:
The most substantial healthcare challenge facing the UK is the inevitable transition towards ageing population. Organ transplantation as the gold-standard treatment has saved many lives and millions of pounds for the NHS; however, every day, 4 people in the UK die while on the waiting list. The development of new and effective artificially engineered organs and tissue grafts without the need for immunosuppression will therefore be necessary to ensure we maintain and improve the healthcare nationally and globally. 3D extrusion-based bioprinting has emerged as a promising 3D printing technology for development of more advanced and functional organs and tissues, as well as drug development, and 3D in vitro disease models1,2. However, current developments are not able to recapitulate the heterogeneity and complexity of organs and tissues (Fig. 1A). Recent studies1,2 have demonstrated the potential use of microfluidic-based 3D printing by allowing more control and precision over the organisation of biomolecules, cells and material thus, enabling fabrication of complex 3D constructs. However, the traditional fabrication method for such devices is labour-intensive and expensive, limiting its widespread use. Herein, we proposed an agile and novel manufacturing pipeline based on COntinously Varied Extrusion (CONVEX)3 design approach in extrusion-based printing to develop integrated 3D-printed microfluidic chip nozzles, based on microfluidic mixers and hydrodynamic flow focusing components (Fig. 1B) with the potential to fabricate blood vessels.

Citation

Moetazedian, A., Cox, L., Grover, L., & Poologasundarampillai, G. (2022, June). Microfluidic-based 3D bioprinting to fabricate blood vasculature. Presented at UK Society for Biomaterials 22nd Annual Conference (UKSB 2022), University of Sheffield

• Presentation Conference Type: Conference Abstract
• Conference Name: UK Society for Biomaterials 22nd Annual Conference (UKSB 2022)
• Start Date: Jun 27, 2022
• End Date: Jun 28, 2022
• Acceptance Date: Feb 13, 2022
• Online Publication Date: Jan 8, 2023
• Publication Date: Jan 8, 2023
• Deposit Date: Oct 10, 2024
• Publicly Available Date: Oct 18, 2024
• Peer Reviewed: Peer Reviewed
• Book Title: UK Society for Biomaterials 22nd Annual Conference Abstract Booklet
• Chapter Number: Session 3: Talk 2
• ISBN: 978-1-9161528-1-6
• Public URL: https://hull-repository.worktribe.com/output/4864059
• Publisher URL: https://www.uksb.org.uk/uksb2022/