Cough frequency has a high daily variation in patients with chronic cough

Morice, Alyn; Alge, Mitja; Kuett, Laura; Hart, Simon; Rigby, Alan; Elkayam, David

Abstract

Opening paragraph:
Chronic cough (coughing lasting 8 weeks or longer) is a burdensome disease, causing low quality of life due to the disruption that frequent coughing causes to daily life. Its prevalence is estimated to be 10% of the global population. Chronic cough can be due to underlying conditions such as asthma and COPD, or can persist despite treatment (refractory chronic cough) or have unidentified origins (unexplained chronic cough). Due to its prevalence and lack of effective treatments, there is high interest in developing drugs for refractory and unexplained chronic cough. Cough frequency, represented as coughs per hour measured over 24 h or awake time, has been used as a key endpoint in multiple clinical drug trials.

Citation

Morice, A., Alge, M., Kuett, L., Hart, S., Rigby, A., & Elkayam, D. (2025). Cough frequency has a high daily variation in patients with chronic cough. ERJ Open Research, 11(1), Article 00670-2024. https://doi.org/10.1183/23120541.00670-2024

• Journal Article Type: Letter
• Acceptance Date: Aug 21, 2024
• Online Publication Date: Feb 10, 2025
• Publication Date: 2025-01
• Deposit Date: May 10, 2025
• Publicly Available Date: May 13, 2025
• Electronic ISSN: 2312-0541
• Publisher: European Respiratory Society
• Peer Reviewed: Peer Reviewed
• Volume: 11
• Issue: 1
• Article Number: 00670-2024
• DOI: https://doi.org/10.1183/23120541.00670-2024
• Public URL: https://hull-repository.worktribe.com/output/5041276