Diagnostic value of reflux episodes in gastroesophageal reflux-induced chronic cough: a novel predictive indicator

Wang, Shengyuan; Wen, Siwan; Bai, Xiao; Zhang, Mengru; Zhu, Yiqing; Wu, Mingyan; Lu, Lihua; Shi, Cuiqin; Yu, Li; Xu, Xianghuai

Abstract

Background: Multichannel intraluminal impedance and pH-monitoring (MII-pH) is an essential testing modality for gastroesophageal reflux-induced chronic cough (GERC), while the existing diagnostic criteria still have some inherent defects. This study aimed to explore the diagnostic value of a direct and objective index, reflux episodes, and related parameters in MII-pH in different types of GERC. Methods: Patients with chronic cough suspected of gastroesophageal reflux disease who successfully received MII-pH were enrolled. The differences in MII-pH parameters were analyzed among patients with different etiologies and the predictive diagnostic value of reflux episodes and related parameters were analyzed in patients with GERC, acid GERC, and non-acid GERC, and compared with existing diagnostic criteria. Results: A total of 190 patients with suspected GERC who underwent MII-pH were enrolled; 131 of these patients were finally diagnosed with GERC. When the reflux episodes were used to diagnose GERC, the area under the curve (AUC) was 0.684; when the acid reflux episodes and the ratio of acid reflux episodes were used to diagnose acid GERC, the AUCs were 0.769 and 0.854; when the non-acid reflux episodes and the ratio of non-acid reflux episodes were used to diagnose non-acid GERC, the AUCs were 0.735 and 0.705, respectively. When the non-acid reflux episodes > 58 and the proportion of non-acid reflux episodes > 68.18% were used alone or in combination to diagnose non-acid GERC, their diagnostic value was significantly better than SAP or SI (all ps < 0.05). Conclusion: The number of reflux episodes has a good diagnostic value for GERC, especially in the diagnosis of non-acid GERC.

Citation

Wang, S., Wen, S., Bai, X., Zhang, M., Zhu, Y., Wu, M., Lu, L., Shi, C., Yu, L., & Xu, X. (2022). Diagnostic value of reflux episodes in gastroesophageal reflux-induced chronic cough: a novel predictive indicator. Therapeutic Advances in Chronic Disease, 13, https://doi.org/10.1177/20406223221117455

• Journal Article Type: Article
• Acceptance Date: Jun 15, 2022
• Online Publication Date: Aug 17, 2022
• Publication Date: Jan 1, 2022
• Deposit Date: Jun 17, 2025
• Publicly Available Date: Jun 20, 2025
• Journal: Therapeutic Advances in Chronic Disease
• Print ISSN: 2040-6223
• Electronic ISSN: 2040-6231
• Publisher: SAGE Publications
• Peer Reviewed: Peer Reviewed
• Volume: 13
• DOI: https://doi.org/10.1177/20406223221117455
• Keywords: Cough; Diagnosis; Gastroesophageal reflux; Multichannel intraluminal impedance-pH monitoring
• Public URL: https://hull-repository.worktribe.com/output/5239676