N. E. Jones
Fluoride doped γ-Fe2O3 nanoparticles with increased MRI relaxivity
Jones, N. E.; Burnett, C. A.; Salamon, S.; Landers, J.; Wende, H.; Lazzarini, L.; Gibbs, P.; Pickles, M.; Johnson, B. R.G.; Evans, D. J.; Archibald, S. J.; Francesconi, M. G.
Authors
C. A. Burnett
S. Salamon
J. Landers
H. Wende
L. Lazzarini
P. Gibbs
M. Pickles
B. R.G. Johnson
D. J. Evans
Professor Steve Archibald S.J.Archibald@hull.ac.uk
Professor in Molecular Imaging
Dr Grazia Francesconi M.G.Francesconi@hull.ac.uk
Senior Lecturer
Abstract
Iron oxide nanoparticles (IONs) are being actively researched and experimented with as contrast agents for Magnetic Resonance Imaging (MRI), as well as image-directed delivery of therapeutics. The efficiency of an MRI contrast agent can be described by its longitudinal and transverse relaxivities, r 1 and r 2 . γ-Fe 2 O 3 nanoparticles-doped with fluoride in a controlled manner and functionalised with citric acid-showed a 3-fold increase in r 1 and a 17-fold increase in r 2 in a magnetic field of 3 T and almost 6-fold increase in r 1 and a 14-fold increase in r 2 at 11 T. Following fluorination, PXRD shows that the crystal structure of γ-Fe 2 O 3 is maintained, Mössbauer spectroscopy shows that the oxidation state of the Fe cation is unchanged and HREM shows that the particle size does not vary. However, magnetisation curves show a large increase in the coercive field, pointing towards a large increase in the magnetic anisotropy for the fluorinated nanoparticles compared to the un-doped γ-Fe 2 O 3 nanoparticles. Therefore, a chemically induced increase in magnetic anisotropy appears to be the most relevant parameter responsible for the large increase in relaxivity for γ-Fe 2 O 3 nanoparticles.
Citation
Jones, N. E., Burnett, C. A., Salamon, S., Landers, J., Wende, H., Lazzarini, L., …Francesconi, M. G. (2018). Fluoride doped γ-Fe2O3 nanoparticles with increased MRI relaxivity. Journal of Materials Chemistry B, 6(22), 3665-3673. https://doi.org/10.1039/c8tb00360b
Journal Article Type | Article |
---|---|
Acceptance Date | Mar 28, 2018 |
Online Publication Date | Apr 4, 2018 |
Publication Date | Apr 4, 2018 |
Deposit Date | Apr 13, 2018 |
Publicly Available Date | Apr 5, 2019 |
Journal | Journal of Materials Chemistry B |
Print ISSN | 2050-750X |
Electronic ISSN | 2050-750X |
Publisher | Royal Society of Chemistry |
Peer Reviewed | Peer Reviewed |
Volume | 6 |
Issue | 22 |
Pages | 3665-3673 |
DOI | https://doi.org/10.1039/c8tb00360b |
Keywords | General Materials Science; General Chemistry; Biomedical Engineering; General Medicine |
Public URL | https://hull-repository.worktribe.com/output/778312 |
Publisher URL | http://pubs.rsc.org/en/Content/ArticleLanding/2018/TB/C8TB00360B#!divAbstract |
Additional Information | : This document is Similarity Check deposited; : C. A. Burnett (ORCID); : C. A. Burnett (ResearcherID); : S. Salamon (ORCID); : J. Landers (ORCID); : H. Wende (ORCID); : B. R. G. Johnson (ORCID); : M. G. Francesconi (ORCID); : Single-blind; : Received 5 February 2018; Accepted 28 March 2018; Accepted Manuscript published 4 April 2018; Advance Article published 9 April 2018 |
Files
Article
(1.3 Mb)
PDF
Copyright Statement
©2018 The University of Hull
You might also like
Photocatalytic Hydrolysis─A Sustainable Option for the Chemical Upcycling of Polylactic Acid
(2023)
Journal Article
Utilisation of CO2 as “Structure Modifier” of Inorganic Solids
(2021)
Journal Article
Utilisation of CO 2 as "Structure Modifier" of Inorganic Solids
(2021)
Journal Article
Downloadable Citations
About Repository@Hull
Administrator e-mail: repository@hull.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search