Effect of beta-adrenergic blockade on weight changes in patients with chronic heart failure

Sze, Shirley; Pellicori, Pierpaolo; Kamzi, Syed; Anton, Alexandru; Clark, Andrew L.

Abstract

Abstract:
Background:
Weight loss is common in patients with chronic heart failure (CHF) and is associated with adverse outcome. Activation of the sympathetic nervous system has been implicated in weight loss, wasting and cachexia. However, the effect of sympathetic antagonism on weight change in patients with CHF is not well defined.
Methods:
We evaluated changes in body weight, the incidence of cachexia (weight loss > 6%) and significant weight gain (>5%) in unselected patients with CHF due to left ventricular systolic dysfunction (LVSD) (LV ejection fraction (LVEF)

Citation

Sze, S., Pellicori, P., Kamzi, S., Anton, A., & Clark, A. L. (2018). Effect of beta-adrenergic blockade on weight changes in patients with chronic heart failure. International journal of cardiology, 264, 104-112. https://doi.org/10.1016/j.ijcard.2018.03.089

• Journal Article Type: Article
• Acceptance Date: Mar 19, 2018
• Online Publication Date: Mar 22, 2018
• Publication Date: Aug 1, 2018
• Deposit Date: Jul 17, 2018
• Publicly Available Date: Mar 23, 2019
• Print ISSN: 0167-5273
• Electronic ISSN: 1874-1754
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 264
• Pages: 104-112
• DOI: https://doi.org/10.1016/j.ijcard.2018.03.089
• Keywords: Heart failure; Cachexia; Weight change; Beta-blocker; Sympathetic activation
• Public URL: https://hull-repository.worktribe.com/output/932292
• Publisher URL: https://www.internationaljournalofcardiology.com/article/S0167-5273(17)37814-2/abstract
• Related Public URLs: http://eprints.gla.ac.uk/160158/