All Outputs (93)

Aspartame sensitivity? : a double blind randomised crossover study (2015)
Journal Article
Sathyapalan, T., Thatcher, N. J., Hammersley, R., Rigby, A. S., Pechlivanis, A., Gooderham, N. J., Holmes, E., Le Roux, C. W., Atkin, S. L., & Courts, F. (2015). Aspartame sensitivity? : a double blind randomised crossover study. PLoS ONE, 10(3), e0116212. https://doi.org/10.1371/journal.pone.0116212

Background Aspartame is a commonly used intense artificial sweetener, being approximately 200 times sweeter than sucrose. There have been concerns over aspartame since approval in the 1980s including a large anecdotal database reporting severe sympto... Read More about Aspartame sensitivity? : a double blind randomised crossover study.

Efficacy of β blockers in patients with heart failure plus atrial fibrillation: An individual-patient data meta-analysis (2014)
Journal Article
Kotecha, D., Holmes, J., Krum, H., Altman, D. G., Manzano, L., Cleland, J. G., Lip, G. Y., Coats, A. J., Andersson, B., Kirchhof, P., Von Lueder, T. G., Wedel, H., Rosano, G., Shibata, M. C., Rigby, A., & Flather, M. D. (2014). Efficacy of β blockers in patients with heart failure plus atrial fibrillation: An individual-patient data meta-analysis. Lancet, 384(9961), 2235-2243. https://doi.org/10.1016/S0140-6736%2814%2961373-8

Background: Atrial fibrillation and heart failure often coexist, causing substantial cardiovascular morbidity and mortality. β blockers are indicated in patients with symptomatic heart failure with reduced ejection fraction; however, the efficacy of... Read More about Efficacy of β blockers in patients with heart failure plus atrial fibrillation: An individual-patient data meta-analysis.

Fracture healing following high energy tibial trauma: Ilizarov versus Taylor Spatial Frame (2014)
Journal Article
Menakaya, C., Rigby, A., Hadland, Y., Barron, E., & Sharma, H. (2014). Fracture healing following high energy tibial trauma: Ilizarov versus Taylor Spatial Frame. Annals of the Royal College of Surgeons of England, 96(2), 106-110. https://doi.org/10.1308/003588414x13824511650335

Introduction: The optimal treatment of high energy tibial fractures remains controversial and a challenging orthopaedic problem. The role of external fi xators for all these tibial fractures has been shown to be crucial. Methods: A fi ve-year consecu... Read More about Fracture healing following high energy tibial trauma: Ilizarov versus Taylor Spatial Frame.

Development of a composite model derived from cardiopulmonary exercise tests to predict mortality risk in patients with mild-to-moderate heart failure (2014)
Journal Article
Ingle, L., Rigby, A. S., Sloan, R., Carroll, S., Goode, K. M., Cleland, J. G., & Clark, A. L. (2014). Development of a composite model derived from cardiopulmonary exercise tests to predict mortality risk in patients with mild-to-moderate heart failure. Heart, 100(10), 781-786. https://doi.org/10.1136/heartjnl-2013-304614

Objective: Cardiopulmonary exercise testing (CPET) is used to predict outcome in patients with mild-to-moderate heart failure (HF). Single CPET-derived variables are often used, but we wanted to see if a composite score achieved better predictive pow... Read More about Development of a composite model derived from cardiopulmonary exercise tests to predict mortality risk in patients with mild-to-moderate heart failure.

Acute hypertriglyceridemia induces platelet hyperactivity that is not attenuated by insulin in polycystic ovary syndrome. (2014)
Journal Article
Aye, M. M., Kilpatrick, E. S., Aburima, A., Wraith, K. S., Magwenzi, S., Spurgeon, B., …Atkin, S. L. (2014). Acute hypertriglyceridemia induces platelet hyperactivity that is not attenuated by insulin in polycystic ovary syndrome. Journal of the American Heart Association, 3(1), https://doi.org/10.1161/JAHA.113.000706

Atherothrombosis is associated with platelet hyperactivity. Hypertriglyceridemia and insulin resistance (IR) are features of polycystic ovary syndrome (PCOS). The effect of induced hypertriglyceridemia on IR and platelet function was examined in youn... Read More about Acute hypertriglyceridemia induces platelet hyperactivity that is not attenuated by insulin in polycystic ovary syndrome..

Glucagon-like peptide-1 analogue, liraglutide, improves liver fibrosis markers in obese women with polycystic ovary syndrome and nonalcoholic fatty liver disease (2013)
Journal Article
Kahal, H., Abouda, G., Rigby, A. S., Coady, A. M., Kilpatrick, E. S., & Atkin, S. L. (2014). Glucagon-like peptide-1 analogue, liraglutide, improves liver fibrosis markers in obese women with polycystic ovary syndrome and nonalcoholic fatty liver disease. Clinical Endocrinology, 81(4), 523-528. https://doi.org/10.1111/cen.12369

© 2013 John Wiley & Sons Ltd. Introduction: Nonalcoholic fatty liver disease (NAFLD) has been linked to polycystic ovary syndrome (PCOS) and carries an increased risk of liver cirrhosis. Procollagen type 3 amino-terminal peptide (PIIINP) is an inde... Read More about Glucagon-like peptide-1 analogue, liraglutide, improves liver fibrosis markers in obese women with polycystic ovary syndrome and nonalcoholic fatty liver disease.

Glycemic Control in the 12 Months following a Change to SI Hemoglobin A1c Reporting Units (2013)
Journal Article
Rigby, A., Atkin, S., Barth, J. H., & Kilpatrick, E. (2013). Glycemic Control in the 12 Months following a Change to SI Hemoglobin A1c Reporting Units. Clinical Chemistry, 59(10), 1457-1460. https://doi.org/10.1373/clinchem.2013.206334

BACKGROUND Many countries have implemented, or are considering, a change in hemoglobin A1c (Hb A1c) units from traditional percentage values [Diabetes Control and Complications Trial (DCCT)] to the new Système International d'Unités (SI) unit in mill... Read More about Glycemic Control in the 12 Months following a Change to SI Hemoglobin A1c Reporting Units.

Extension MRI is clinically useful in cervical myelopathy (2013)
Journal Article
Bartlett, R. J. V., Rigby, A. S., Joseph, J., Raman, A., Kunnacherry, A., & Hill, C. A. R. (2013). Extension MRI is clinically useful in cervical myelopathy. Neuroradiology, 55(9), 1081-1088. https://doi.org/10.1007/s00234-013-1208-z

Introduction: Cervical spine MRI with the neck in extension has been well described over the last 10 years, but its clinical value remains unknown. Methods: We performed extension imaging in 60 patients in whom the initial neutral study showed border... Read More about Extension MRI is clinically useful in cervical myelopathy.

Polycystic ovary syndrome has no independent effect on vascular, inflammatory or thrombotic markers when matched for obesity (2013)
Journal Article
Kahal, H., Aburima, A., Ungvari, T., Rigby, A. S., Dawson, A. J., Coady, A. M., Vince, R. V., Ajjan, R. A., Kilpatrick, E. S., Naseem, K. M., & Atkin, S. L. (2013). Polycystic ovary syndrome has no independent effect on vascular, inflammatory or thrombotic markers when matched for obesity. Clinical Endocrinology, 79(2), 252-258. https://doi.org/10.1111/cen.12137

Introduction Previous studies investigating cardiovascular (CV) risk in obese women with polycystic ovary syndrome (PCOS) have been potentially confounded by not adequately accounting for body weight. Objective To assess if PCOS increases CV risk ind... Read More about Polycystic ovary syndrome has no independent effect on vascular, inflammatory or thrombotic markers when matched for obesity.

Interplay between right ventricular function and cardiac resynchronization therapy : an analysis of the CARE-HF trial (cardiac resynchronization–heart failure) (2013)
Journal Article
Damy, T., Ghio, S., Rigby, A. S., Hittinger, L., Jacobs, S., Leyva, F., Delgado, J. F., Daubert, J.-C., Gras, D., Tavazzi, L., & Cleland, J. G. (2013). Interplay between right ventricular function and cardiac resynchronization therapy : an analysis of the CARE-HF trial (cardiac resynchronization–heart failure). Journal of the American College of Cardiology, 61(21), 2153-2160. https://doi.org/10.1016/j.jacc.2013.02.049

Objectives: The aim of this study was to investigate the impact of cardiac resynchronization therapy (CRT) on right ventricular (RV) function and the influence of RV dysfunction on the echocardiographic and clinical response to CRT among patients enr... Read More about Interplay between right ventricular function and cardiac resynchronization therapy : an analysis of the CARE-HF trial (cardiac resynchronization–heart failure).

Initial evidence of the reliability and validity of a three-dimensional body rating scale for the congenitally blind (2013)
Journal Article
Rocha Morgado, F. F., Ferreira, M. E. C., Campana, A. N., Rigby, A. S., & Tavares, M. D. C. G. (2013). Initial evidence of the reliability and validity of a three-dimensional body rating scale for the congenitally blind. Perceptual and Motor Skills, 116(1), 91-105. https://doi.org/10.2466/24.15.27.PMS.116.1.91-105

Research on body dissatisfaction has grown significantly. However, valid and reliable instruments for measuring body dissatisfaction in the congenitally blind have yet to be developed. In three studies, we report on development, test-retest reliabili... Read More about Initial evidence of the reliability and validity of a three-dimensional body rating scale for the congenitally blind.

Individual patient data meta-analysis of beta-blockers in heart failure: rationale and design (2013)
Journal Article
Kotecha, D., Manzano, L., Altman, D. G., Krum, H., Erdem, G., Williams, N., …Beta-Blockers in Heart Failure Collaborative Group. (2013). Individual patient data meta-analysis of beta-blockers in heart failure: rationale and design. Systematic reviews, 2(1), Article 7. https://doi.org/10.1186/2046-4053-2-7

The Beta-Blockers in Heart Failure Collaborative Group (BB-HF) was formed to obtain and analyze individual patient data from the major randomized controlled trials of beta-blockers in heart failure. Even though beta-blockers are an established treatm... Read More about Individual patient data meta-analysis of beta-blockers in heart failure: rationale and design.

The effect of parathyroidectomy on neuropsychological symptoms and biochemical parameters in patients with asymptomatic primary hyperparathyroidism: pHPT neuropsychological symptoms (2012)
Journal Article
Kahal, H., Aye, M., Rigby, A. S., Sathyapalan, T., England, R. J. A., & Atkin, S. L. (2012). The effect of parathyroidectomy on neuropsychological symptoms and biochemical parameters in patients with asymptomatic primary hyperparathyroidism: pHPT neuropsychological symptoms. Clinical Endocrinology, 76(2), 196-200. https://doi.org/10.1111/j.1365-2265.2011.04197.x

Background With increased biochemical screening, primary hyperparathyroidism (pHPT) is often discovered incidentally whilst patients are asymptomatic. Objective To assess the impact of parathyroidectomy on neuropsychological symptoms and biochemical... Read More about The effect of parathyroidectomy on neuropsychological symptoms and biochemical parameters in patients with asymptomatic primary hyperparathyroidism: pHPT neuropsychological symptoms.

The effect of soy phytoestrogen supplementation on thyroid status and cardiovascular risk markers in patients with subclinical hypothyroidism: A randomized, double-blind, crossover study (2011)
Journal Article
Sathyapalan, T., Manuchehri, A. M., Thatcher, N. J., Rigby, A. S., Chapman, T., Kilpatrick, E. S., & Atkin, S. L. (2011). The effect of soy phytoestrogen supplementation on thyroid status and cardiovascular risk markers in patients with subclinical hypothyroidism: A randomized, double-blind, crossover study. Journal of Clinical Endocrinology and Metabolism, 96(5), 1442-1449. https://doi.org/10.1210/jc.2010-2255

Context: There is concern whether soy phytoestrogens may affect thyroid function. If true, soy phytoestrogens may be expected to have a greater impact in subjects with subclinical hypothyroidism. Objective: The primary aim was to determine the effect... Read More about The effect of soy phytoestrogen supplementation on thyroid status and cardiovascular risk markers in patients with subclinical hypothyroidism: A randomized, double-blind, crossover study.

The national heart failure audit for England and Wales 2008-2009 (2010)
Journal Article
Yassin, A., Cleland, J., McDonagh, T., Rigby, A. S., Whittaker, T., Dargie, H. J., & on behalf of the National Heart Failure Audit Team for England and Wales. (2011). The national heart failure audit for England and Wales 2008-2009. Heart, 97(11), 876-886. https://doi.org/10.1136/hrt.2010.209171

Objectives To obtain national data on the clinical characteristics, investigation, management and outcome of patients hospitalised with a diagnosis of heart failure. Method A survey was carried out of the first 10 patients hospitalised with a primary... Read More about The national heart failure audit for England and Wales 2008-2009.

Cardiac output does not limit submaximal exercise capacity in patients with chronic heart failure (2010)
Journal Article
Shelton, R. J., Ingle, L., Rigby, A. S., Witte, K. K., Cleland, J. G., & Clark, A. L. (2010). Cardiac output does not limit submaximal exercise capacity in patients with chronic heart failure. European journal of heart failure, 12(9), 983-989. https://doi.org/10.1093/eurjhf/hfq086

Aims
Mechanisms of exercise limitation in patients with chronic heart failure (CHF) are incompletely understood. During matched submaximal, fixed-rate exercise, oxygen uptake is similar in patients and healthy controls. However, the importance of ca... Read More about Cardiac output does not limit submaximal exercise capacity in patients with chronic heart failure.

The role of blood pressure variability in the development of nephropathy in type 1 diabetes (2010)
Journal Article
Kilpatrick, E. S., Rigby, A. S., & Atkin, S. L. (2010). The role of blood pressure variability in the development of nephropathy in type 1 diabetes. Diabetes Care, 33(11), 2442-2447. https://doi.org/10.2337/dc10-1000

OBJECTIVE - Increases in blood pressure and visit-to-visit variability have both been found to independently increase the likelihood of cardiovascular events in nondiabetic individuals. This study has investigated whether each may also influence the... Read More about The role of blood pressure variability in the development of nephropathy in type 1 diabetes.

A randomised trial of high vs low intensity training in breathing techniques for breathless patients with malignant lung disease: A feasibility study (2010)
Journal Article
Barton, R., English, A., Nabb, S., Rigby, A. S., & Johnson, M. J. (2010). A randomised trial of high vs low intensity training in breathing techniques for breathless patients with malignant lung disease: A feasibility study. Lung Cancer, 70(3), 313-319. https://doi.org/10.1016/j.lungcan.2010.03.007

Background: Breathlessness remains a refractory symptom in malignant lung disease. Breathing training is an effective, non-pharmacological intervention but it is unclear how this should be delivered. This feasibility study aimed to assess recruitment... Read More about A randomised trial of high vs low intensity training in breathing techniques for breathless patients with malignant lung disease: A feasibility study.

Subclinical hypothyroidism is associated with reduced all-cause mortality in patients with type 2 diabetes (2010)
Journal Article
Sathyapalan, T., Manuchehri, A. M., Rigby, A. S., & Atkin, S. L. (2010). Subclinical hypothyroidism is associated with reduced all-cause mortality in patients with type 2 diabetes. Diabetes Care, 33(3), e37-e37. https://doi.org/10.2337/dc09-1555

A randomized, controlled dose-ranging study of risedronate in children with moderate and severe osteogenesis imperfecta (2009)
Journal Article
Bishop, N., Harrison, R., Ahmed, F., Shaw, N., Eastell, R., Campbell, M., Knowles, E., Hill, C., Hall, C., Chapman, S., Sprigg, A., & Rigby, A. (2010). A randomized, controlled dose-ranging study of risedronate in children with moderate and severe osteogenesis imperfecta. Journal of Bone and Mineral Research, 25(1), 32-40. https://doi.org/10.1359/jbmr.090712

Moderate to severe osteogenesis imperfecta is associated with multiple fractures in childhood. There are no published data regarding the effects of third-generation bisphosphonates in these children. This randomized study investigated which of three... Read More about A randomized, controlled dose-ranging study of risedronate in children with moderate and severe osteogenesis imperfecta.