All Outputs (8)

Cough hypersensitivity syndrome: A distinct clinical entity (2010)
Journal Article
Morice, A. H., Faruqi, S., Wright, C. E., Thompson, R., & Bland, J. M. (2011). Cough hypersensitivity syndrome: A distinct clinical entity. Lung, 189(1), 73-79. https://doi.org/10.1007/s00408-010-9272-1

We postulate that most patients with chronic cough have a single discrete clinical entity: Cough Hypersensitivity Syndrome. We constructed a questionnaire that elicits the major components of the syndrome. Here we describe the validation of this ques... Read More about Cough hypersensitivity syndrome: A distinct clinical entity.

TRPA1 is activated by direct addition of cysteine residues to the N-hydroxysuccinyl esters of acrylic and cinnamic acids (2010)
Journal Article
Sadofsky, L. R., Boa, A. N., Maher, S. A., Birrell, M. A., Belvisi, M. G., & Morice, A. H. (2011). TRPA1 is activated by direct addition of cysteine residues to the N-hydroxysuccinyl esters of acrylic and cinnamic acids. Pharmacological research : the official journal of the Italian Pharmacological Society, 63(1), 30-36. https://doi.org/10.1016/j.phrs.2010.11.004

The nociceptor TRPA1 is thought to be activated through covalent modification of specific cysteine residues on the N terminal of the channel. The precise mechanism of covalent modification with unsaturated carbonyl-containing compounds is unclear, th... Read More about TRPA1 is activated by direct addition of cysteine residues to the N-hydroxysuccinyl esters of acrylic and cinnamic acids.

Quantifying chronic cough: Objective versus subjective measurements (2010)
Journal Article
Faruqi, S., Thompson, R., Wright, C., Sheedy, W., & Morice, A. H. (2011). Quantifying chronic cough: Objective versus subjective measurements. Respirology : official journal of the Asian Pacific Society of Respirology, 16(2), 314-320. https://doi.org/10.1111/j.1440-1843.2010.01893.x

Background and objective: The assessment of chronic cough has been improved by the development of objective ambulatory cough monitoring systems and subjective quality of life questionnaires. Experimental induction of cough is a useful tool in the ass... Read More about Quantifying chronic cough: Objective versus subjective measurements.

Clinical expert guidelines for the management of cough in lung cancer: Report of a UK task group on cough (2010)
Journal Article
Molassiotis, A., Smith, J. A., Bennett, M. I., Blackhall, F., Taylor, D., Zavery, B., Harle, A., Booton, R., Rankin, E. M., Lloyd-Williams, M., & Morice, A. H. (2010). Clinical expert guidelines for the management of cough in lung cancer: Report of a UK task group on cough. Cough, 6(1), Article 9. https://doi.org/10.1186/1745-9974-6-9

Background: Cough is a common and distressing symptom in lung cancer patients. The clinical management of cough in lung cancer patients is suboptimal with limited high quality research evidence available. The aim of the present paper is to present a... Read More about Clinical expert guidelines for the management of cough in lung cancer: Report of a UK task group on cough.

Treatment of cystic fibrosis associated cutaneous vasculitis with chloroquine (2010)
Journal Article
Molyneux, I. D., Moon, T., Webb, A. K., & Morice, A. H. (2010). Treatment of cystic fibrosis associated cutaneous vasculitis with chloroquine. Journal of Cystic Fibrosis, 9(6), 439-441. https://doi.org/10.1016/j.jcf.2010.08.017

Vasculitis is a well recognised complication of Cystic Fibrosis. Corticosteroids are the mainstay of treatment but some cases can be resistant and may require additional disease modifying agents.We describe a case of steroid resistant cutaneous vascu... Read More about Treatment of cystic fibrosis associated cutaneous vasculitis with chloroquine.

COPD in young patients: A pre-specified analysis of the four-year trial of tiotropium (UPLIFT) (2010)
Journal Article
Morice, A. H., Celli, B., Kesten, S., Lystig, T., Tashkin, D., & Decramer, M. (2010). COPD in young patients: A pre-specified analysis of the four-year trial of tiotropium (UPLIFT). Respiratory medicine, 104(11), 1659-1667. https://doi.org/10.1016/j.rmed.2010.07.016

Whilst recent large-scale studies have provided much evidence on the natural history and therapeutic response in patients with chronic obstructive pulmonary disease (COPD), relatively little is known about the effect in younger patients. We report a... Read More about COPD in young patients: A pre-specified analysis of the four-year trial of tiotropium (UPLIFT).

Validation of the ERS standard citric acid cough challenge in healthy adult volunteers (2010)
Journal Article
Wright, C. E., Jackson, J., Thompson, R. L., & Morice, A. H. (2010). Validation of the ERS standard citric acid cough challenge in healthy adult volunteers. Cough, 6(1), Article 8. https://doi.org/10.1186/1745-9974-6-8

Protocols measuring cough sensitivity can vary in terms of nebuliser, tussive agent, single and dose response. A definitive method for measuring cough sensitivity needs to be established. The ERS guidelines recommend the KoKo DigiDoser (KD) delivery... Read More about Validation of the ERS standard citric acid cough challenge in healthy adult volunteers.

Chronic cough associated with Crohn's disease (2010)
Journal Article
Faruqi, S., Avery, G., & Morice, A. H. (2010). Chronic cough associated with Crohn's disease. Cough, 6(1), https://doi.org/10.1186/1745-9974-6-6

A 62-year-old man presented with chronic dry cough. He was known to have Crohn's disease which was in remission. A plain chest radiograph demonstrated bilateral apical infiltrates. A HRCT of the chest showed normal proximal airways. Stenosis of mediu... Read More about Chronic cough associated with Crohn's disease.