Skip to main content

Research Repository

Advanced Search

Validation of the ERS standard citric acid cough challenge in healthy adult volunteers

Wright, Caroline E.; Jackson, Jennifer; Thompson, Rachel L.; Morice, Alyn H.

Authors

Caroline E. Wright

Jennifer Jackson

Rachel L. Thompson



Abstract

Protocols measuring cough sensitivity can vary in terms of nebuliser, tussive agent, single and dose response. A definitive method for measuring cough sensitivity needs to be established. The ERS guidelines recommend the KoKo DigiDoser (KD) delivery system. Study aim, was to compare the reproducibility of this citric acid (CA) cough challenge and previously established Mefar dosimeter (MD) protocol. 39 (female 26) volunteers mean age (40.4 yrs) were randomised to either KD or MD. Intra-day and inter-day reproducibility was compared. We calculated the concentration of citric acid evoking 2 coughs (C2). The geometric mean C2 (95%CI) was similar for both KD and MD, of 263 (200,339) mM and 209 (151,288) mM respectively. The mean KD C2 was not significantly different. (F = 0.807, p = 0.93) from baseline over 1, 2, and 4 hrs however, the MD demonstrated significant variability (F = 7.85, P < 0.001) Measuring mean log C2 at baseline and at 2 weeks, the KD demonstrated a stronger intraclass correlation of log C2 at baseline with 2 week log C2, ICC = 0.70 than was shown with the Mefar, ICC = 0.41 Administering CA from KD offers a reproducible cough challenge in healthy volunteers. The results correlate well with the MD challenge but offer greater intra-day and inter-day reproducibility. © 2010 Wright et al; licensee BioMed Central Ltd.

Citation

Wright, C. E., Jackson, J., Thompson, R. L., & Morice, A. H. (2010). Validation of the ERS standard citric acid cough challenge in healthy adult volunteers. Cough, 6(1), Article 8. https://doi.org/10.1186/1745-9974-6-8

Journal Article Type Article
Acceptance Date Aug 10, 2010
Online Publication Date Aug 10, 2010
Publication Date Aug 10, 2010
Deposit Date May 24, 2022
Publicly Available Date Jul 17, 2024
Journal Cough
Print ISSN 1745-9974
Publisher BioMed Central
Peer Reviewed Peer Reviewed
Volume 6
Issue 1
Article Number 8
DOI https://doi.org/10.1186/1745-9974-6-8
Public URL https://hull-repository.worktribe.com/output/3610333

Files

Published article (999 Kb)
PDF

Publisher Licence URL
http://creativecommons.org/licenses/by/2.0

Copyright Statement
© 2010 Wright et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons
Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in
any medium, provided the original work is properly cited.






You might also like



Downloadable Citations