Skip to main content

Research Repository

Advanced Search

TRPV1 polymorphisms influence capsaicin cough sensitivity in men

Sadofsky, Laura R.; Cantero-Recasens, Gerard; Wright, Caroline; Valverde, Miguel A.; Morice, Alyn H.

Authors

Dr Laura Sadofsky L.R.Sadofsky@hull.ac.uk
Lecturer in Respiratory Medicine/ Academic lead for postgraduate training in HYMS

Gerard Cantero-Recasens

Caroline Wright

Miguel A. Valverde

Alyn H. Morice



Abstract

Capsaicin, the hot component of chilli peppers, is a well-known tussive agent, which is regularly used as a tool to study cough and antitussives (1). Capsaicin is known to activate the transient receptor potential vanilloid 1 (TRPV1) cation channel which is thought to be involved in pain perception, inflammation, itch and cough (2-4). These functions within the body make TRPV1 an exciting target for research and drug development.

Citation

Sadofsky, L. R., Cantero-Recasens, G., Wright, C., Valverde, M. A., & Morice, A. H. (2017). TRPV1 polymorphisms influence capsaicin cough sensitivity in men. Journal of thoracic disease, 9(3), 839-840. doi:10.21037/jtd.2017.03.50

Journal Article Type Article
Acceptance Date Feb 6, 2017
Publication Date Mar 1, 2017
Deposit Date Feb 24, 2017
Publicly Available Date
Journal Journal of thoracic disease
Print ISSN 2072-1439
Electronic ISSN 2077-6624
Peer Reviewed Peer Reviewed
Volume 9
Issue 3
Pages 839-840
DOI https://doi.org/10.21037/jtd.2017.03.50
Keywords capsaicin, cough, genetic polymorphism, TRPV1, cough, polymorphism, TRPV1
Public URL https://hull-repository.worktribe.com/output/448853
Publisher URL http://jtd.amegroups.com/article/view/12417
Additional Information This is a description of an article accepted for publication in Journal of thoracic disease, 2017, v.9 issue 3. Full text is not currently available in this repository.