TRPV1 polymorphisms influence capsaicin cough sensitivity in men

Sadofsky, Laura R.; Cantero-Recasens, Gerard; Wright, Caroline; Valverde, Miguel A.; Morice, Alyn H.

Abstract

Capsaicin, the hot component of chilli peppers, is a well-known tussive agent, which is regularly used as a tool to study cough and antitussives (1). Capsaicin is known to activate the transient receptor potential vanilloid 1 (TRPV1) cation channel which is thought to be involved in pain perception, inflammation, itch and cough (2-4). These functions within the body make TRPV1 an exciting target for research and drug development.

Citation

Sadofsky, L. R., Cantero-Recasens, G., Wright, C., Valverde, M. A., & Morice, A. H. (2017). TRPV1 polymorphisms influence capsaicin cough sensitivity in men. Journal of thoracic disease, 9(3), 839-840. https://doi.org/10.21037/jtd.2017.03.50

• Journal Article Type: Article
• Acceptance Date: Feb 6, 2017
• Publication Date: Mar 1, 2017
• Deposit Date: Feb 24, 2017
• Journal: Journal of thoracic disease
• Print ISSN: 2072-1439
• Peer Reviewed: Peer Reviewed
• Volume: 9
• Issue: 3
• Pages: 839-840
• DOI: https://doi.org/10.21037/jtd.2017.03.50
• Keywords: capsaicin, cough, genetic polymorphism, TRPV1, cough, polymorphism, TRPV1
• Public URL: https://hull-repository.worktribe.com/output/448853
• Publisher URL: http://jtd.amegroups.com/article/view/12417
• Additional Information: This is a description of an article accepted for publication in Journal of thoracic disease, 2017, v.9 issue 3. Full text is not currently available in this repository.
• Contract Date: Feb 24, 2017