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TRPV1 polymorphisms influence capsaicin cough sensitivity in men

Sadofsky, Laura R.; Cantero-Recasens, Gerard; Wright, Caroline; Valverde, Miguel A.; Morice, Alyn H.


Dr Laura Sadofsky
Lecturer in Respiratory Medicine/ Academic lead for postgraduate training in HYMS

Gerard Cantero-Recasens

Caroline Wright

Miguel A. Valverde

Alyn H. Morice


Capsaicin, the hot component of chilli peppers, is a well-known tussive agent, which is regularly used as a tool to study cough and antitussives (1). Capsaicin is known to activate the transient receptor potential vanilloid 1 (TRPV1) cation channel which is thought to be involved in pain perception, inflammation, itch and cough (2-4). These functions within the body make TRPV1 an exciting target for research and drug development.

Journal Article Type Article
Publication Date Mar 1, 2017
Journal Journal of thoracic disease
Print ISSN 2072-1439
Electronic ISSN 2077-6624
Peer Reviewed Peer Reviewed
Volume 9
Issue 3
Pages 839-840
APA6 Citation Sadofsky, L. R., Cantero-Recasens, G., Wright, C., Valverde, M. A., & Morice, A. H. (2017). TRPV1 polymorphisms influence capsaicin cough sensitivity in men. Journal of thoracic disease, 9(3), 839-840. doi:10.21037/jtd.2017.03.50
Keywords capsaicin, cough, genetic polymorphism, TRPV1, cough, polymorphism, TRPV1
Publisher URL
Additional Information This is a description of an article accepted for publication in Journal of thoracic disease, 2017, v.9 issue 3. Full text is not currently available in this repository.