Outputs (932)

Environmental fluoxetine promotes skin cell proliferation and wound healing (2024)
Journal Article
Rodriguez-Barucg, Q., Garcia, A., Garcia-Merino, B., Akinmola, T., Okotie-Eboh, T., Francis, T., Bringas, E., Ortiz, I., Wade, M., Dowle, A., Joyce, D., Hardman, M., Wilkinson, H., & Beltran-Alvarez, P. (2024). Environmental fluoxetine promotes skin cell proliferation and wound healing. Environmental Pollution, 362, Article 124952. https://doi.org/10.1016/j.envpol.2024.124952

This study investigates the effects of environmentally-relevant concentrations of fluoxetine (FLX, commercial name: Prozac) on wound healing. Pollution of water systems with pharmaceutical and personal care products, including antidepressants such as... Read More about Environmental fluoxetine promotes skin cell proliferation and wound healing.

Brain and Lung Biomarker Responses to Hyperoxic Hypobaric Decompression (2024)
Journal Article
Connolly, D., Madden, L., Edwards, V., & Lee, V. (2024). Brain and Lung Biomarker Responses to Hyperoxic Hypobaric Decompression. Aerospace Medicine and Human Performance, 95(9), 667-674. https://doi.org/10.3357/AMHP.6391.2024

INTRODUCTION: Biomarker responses to intensive decompression indicate systemic pro-inflammatory responses and possible neurological stress. Twelve additional brain and lung
biomarkers were assayed to further investigate responses. METHODS: Fifteen h... Read More about Brain and Lung Biomarker Responses to Hyperoxic Hypobaric Decompression.

Cancer screening attendance rates in transgender and gender-diverse patients: a systematic review and meta-analysis (2024)
Journal Article
Chan, A., Jamieson, C., Draper, H., O'Callaghan, S., & Guinn, B. A. (online). Cancer screening attendance rates in transgender and gender-diverse patients: a systematic review and meta-analysis. BMJ Evidence-Based Medicine, https://doi.org/10.1136/bmjebm-2023-112719

Objectives: To examine disparities in attendance rates at cancer screening services between transgender and gender-diverse (TGD) people in comparison with their cisgender (CG) counterparts, and to determine whether these differences were based on the... Read More about Cancer screening attendance rates in transgender and gender-diverse patients: a systematic review and meta-analysis.

Biomarker Driven Antifungal Stewardship (BioDriveAFS) in acute leukaemia—a multi-centre randomised controlled trial to assess clinical and cost effectiveness: a study protocol for a randomised controlled trial (2024)
Journal Article
Flett, L., Abdelatif, R., Akhtar Baz, S., Brady, S., Corbacho, B., Common, K., Cowling, A., Fairhurst, C., Fitzmaurice, E., Gandhi, S., Hilton, A., Hope, W., Howard, A., Laycock, J., Lillie, P., Mitchell, G., Parker, A., Peel, M., Sheard, L., Sneddon, J., …Barlow, G. (2024). Biomarker Driven Antifungal Stewardship (BioDriveAFS) in acute leukaemia—a multi-centre randomised controlled trial to assess clinical and cost effectiveness: a study protocol for a randomised controlled trial. Trials, 25(1), Article 427. https://doi.org/10.1186/s13063-024-08272-w

BACKGROUND: Acute leukaemias (AL) are life-threatening blood cancers that can be potentially cured with treatment involving myelosuppressive, multiagent, intensive chemotherapy (IC). However, such treatment is associated with a risk of serious infect... Read More about Biomarker Driven Antifungal Stewardship (BioDriveAFS) in acute leukaemia—a multi-centre randomised controlled trial to assess clinical and cost effectiveness: a study protocol for a randomised controlled trial.

Comparison of assays measuring extracellular vesicle tissue factor in plasma samples: communication from the ISTH SSC Subcommittee on Vascular Biology (2024)
Journal Article
Bonifay, A., Mackman, N., Hisada, Y., Sachetto, A. T. A., Hau, C., Gray, E., Hogwood, J., Aharon, A., Badimon, L., Barile, L., Baudar, J., Beckmann, L., Benedikter, B., Bolis, S., Bouriche, T., Brambilla, M., Burrello, J., Camera, M., Campello, E., Ettelaie, C., …Lacroix, R. (2024). Comparison of assays measuring extracellular vesicle tissue factor in plasma samples: communication from the ISTH SSC Subcommittee on Vascular Biology. Journal of Thrombosis and Haemostasis, https://doi.org/10.1016/j.jtha.2024.05.037

Background: Scientific and clinical interest in extracellular vesicles (EVs) is growing. EVs that expose tissue factor (TF) bind factor VII/VIIa and can trigger coagulation. Highly procoagulant TF-exposing EVs are detectable in the circulation in var... Read More about Comparison of assays measuring extracellular vesicle tissue factor in plasma samples: communication from the ISTH SSC Subcommittee on Vascular Biology.

‘I'm a failure again, I can't do it’: Attitudes towards, and experiences of, exercise participation in adults with class III obesity (2024)
Journal Article
Orange, S., Roebuck, J., Marshall, P., Madden, L. A., Vince, R. V., & Bell, B. (online). ‘I'm a failure again, I can't do it’: Attitudes towards, and experiences of, exercise participation in adults with class III obesity. British Journal of Health Psychology, https://doi.org/10.1111/bjhp.12739

Objectives: Living within a larger body brings unique challenges to exercise participation, which are poorly understood. This qualitative study explored the attitudes towards, and experiences of, exercise participation in adults with class III obesit... Read More about ‘I'm a failure again, I can't do it’: Attitudes towards, and experiences of, exercise participation in adults with class III obesity.

Endothelial-derived microvesicles promote pro-migratory cross-talk with smooth muscle cells by a mechanism requiring tissue factor and PAR2 activation (2024)
Journal Article
Featherby, S., & Ettelaie, C. (2024). Endothelial-derived microvesicles promote pro-migratory cross-talk with smooth muscle cells by a mechanism requiring tissue factor and PAR2 activation. Frontiers in Cardiovascular Medicine, 11, Article 1365008. https://doi.org/10.3389/fcvm.2024.1365008

Introduction: Microvesicles (MV) released by endothelial cells (EC) following injury or inflammation contain tissue factor (TF) and mediate communication with the underlying smooth muscle cells (SMC). Ser253-phosphorylated TF co-localizes with filami... Read More about Endothelial-derived microvesicles promote pro-migratory cross-talk with smooth muscle cells by a mechanism requiring tissue factor and PAR2 activation.

Calcitonin gene-related peptide and intermedin induce phosphorylation of p44/42 MAPK in primary human lymphatic endothelial cells in vitro (2024)
Journal Article
Hasan, S. R., Manolis, D., Stephenson, E., Ryskiewicz-Sokalska, O. A., Maraveyas, A., & Nikitenko, L. L. (2024). Calcitonin gene-related peptide and intermedin induce phosphorylation of p44/42 MAPK in primary human lymphatic endothelial cells in vitro. Cellular Signalling, 121, Article 111261. https://doi.org/10.1016/j.cellsig.2024.111261

Calcitonin gene-related peptide (CGRP) and adrenomedullin 2/intermedin (AM2/IMD) play important roles in several pathologies, including cardiovascular disease, migraine and cancer. The efficacy of drugs targeting CGRP signalling axis for the treatmen... Read More about Calcitonin gene-related peptide and intermedin induce phosphorylation of p44/42 MAPK in primary human lymphatic endothelial cells in vitro.

Quantitative proteomics reveals CLR interactome in primary human cells (2024)
Journal Article
Manolis, D., Hasan, S., Maraveyas, A., O'Brien, D. P., Kessler, B. M., Kramer, H., & Nikitenko, L. L. (2024). Quantitative proteomics reveals CLR interactome in primary human cells. Journal of Biological Chemistry, 300(6), Article 107399. https://doi.org/10.1016/j.jbc.2024.107399

The G protein–coupled receptor (GPCR) calcitonin receptor–like receptor (CLR) mediates essential functions in several cell types and is implicated in cardiovascular pathologies, skin diseases, migraine, and cancer. To date, the network of proteins in... Read More about Quantitative proteomics reveals CLR interactome in primary human cells.

Can tumour antigens act as biomarkers for the early detection of non-small cell lung cancer? (2024)
Journal Article
Mohamed, E., Fletcher, D., Hart, S., & Guinn, B.-A. (2024). Can tumour antigens act as biomarkers for the early detection of non-small cell lung cancer?. Onco, 4(2), 87-100. https://doi.org/10.3390/onco4020008

Lung cancer (LC) is one of the leading causes of cancer-related deaths. Pulmonary nodules are one of the risk factors and their discovery rate has been increasing due to enhanced performance of chest CT scans but more than 90% are non-malignant causi... Read More about Can tumour antigens act as biomarkers for the early detection of non-small cell lung cancer?.