Dr Laura Sadofsky
| Biography | Laura Sadofsky is interested in ion channels and their role in cough and airways inflammation. Her laboratory is currently using human cells and tissue to develop models of the human airways. Using these models, she hopes to better understand the changes which occur in the airways in response to viruses as well as environmental stimuli, pollutants and pharmaceuticals. |
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| Teaching and Learning | MBBS Medicine - Phase 1 plenary lectures - Pharmacology workshops - Phase 1 and phase 2 SSIPs BSc/MSc Biomedical Science - Research projects Non-medical prescribing MSc Pharmacology and Drug Development MSc Pharmacology and Education (programme director) MSc Physician Associate Studies Health Professions Education |
| PhD Supervision Availability | Yes |
| PhD Topics | Ion channels including the thermo-Transient Receptor Potential (TRP) cation channels TRPA1, TRPV1, TRPV4 and TRPM8 (TRP ankyrin-1, vanilloid-1, vanilloid-4 and melastatin-8) and purinergic receptors P2X2 and P2X3 - Precision Cut Lung Slices (PCLS) - Human rhinovirus - Cough and airways inflammation - The effect of microplastics on respiratory health Completed PhDs Basir Ahmad, Understanding Demulcent Activity (2024) Stinson R, The use of Precision Cut Lung Slices and Co-culture Modelling to Investigate the Effect of Human Rhinovirus on Cough and Airway Inflammation (2020) Atkinson S, The Effect of Human Rhinovirus-16 on Thermo-TRP Channels, Hypotonic Activation and ATP Release (2019) Chandrabalan A, The Mechanism of TRPA1 Activation (2017) Knaggs J D, The Modulation of Transient Receptor Potential A1 Channel by Natural and Novel Semi-synthetic Compounds via Non-covalent Modification (2016). Fraser S D, Peripheral Blood Leukocyte Immune Responses in Sarcoidosis (2016) Current PhDs -Nathan Hayes -Lauren Jenner -Ekanayake Ekanayake -Snehal Kadam - Bwalya Bowden |