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Dr Laura Sadofsky's Outputs (38)

Microplastics in cardiopulmonary bypass: quantification and characterisation of particles across systems (2025)
Journal Article
Green, J. L., Field, D. T., Bennett, R., Jenner, L. C., Chapman, E. C., Sadofsky, L. R., Rotchell, J. M., & Loubani, M. (2025). Microplastics in cardiopulmonary bypass: quantification and characterisation of particles across systems. Interdisciplinary CardioVascular and Thoracic Surgery, 40(6), Article ivaf080. https://doi.org/10.1093/icvts/ivaf080

OBJECTIVES
This study determines the microplastic (MP) levels, dimension, shape, and chemical composition generated from conventional cardiopulmonary bypass and minimally invasive extracorporeal circulation (MiECC) circuits.
METHODS
In vitro conve... Read More about Microplastics in cardiopulmonary bypass: quantification and characterisation of particles across systems.

The treatment of mild upper respiratory tract infections – a position paper with recommendations for best practice (2023)
Journal Article
Smith, A., Kardos, P., Pfaar, O., Randerath, W., Estrada Riolobos, G., Braido, F., & Sadofsky, L. (2023). The treatment of mild upper respiratory tract infections – a position paper with recommendations for best practice. Drugs in Context, 12, Article 2023-4-2. https://doi.org/10.7573/dic.2023-4-2

Following the waning severity of COVID-19 due to vaccination and the development of immunity, the current variants of SARS-CoV-2 often lead to mild upper respiratory tract infections (MURTIs), suggesting it is an appropriate time to review the pathog... Read More about The treatment of mild upper respiratory tract infections – a position paper with recommendations for best practice.

Modulation of transient receptor potential (TRP) channels by plant derived substances used in over-the-counter cough and cold remedies (2023)
Journal Article
Stinson, R. J., Morice, A. H., & Sadofsky, L. R. (2023). Modulation of transient receptor potential (TRP) channels by plant derived substances used in over-the-counter cough and cold remedies. Respiratory Research, 24(1), Article 45. https://doi.org/10.1186/s12931-023-02347-z

Background: Upper respiratory tract infections (URTIs) impact all age groups and have a significant economic and social burden on society, worldwide. Most URTIs are mild and self-limiting, but due to the wide range of possible causative agents, inclu... Read More about Modulation of transient receptor potential (TRP) channels by plant derived substances used in over-the-counter cough and cold remedies.

Ingredients of Vicks VapoRub inhibit rhinovirus-induced ATP release (2023)
Journal Article
Stinson, R. J., Morice, A. H., Ahmad, B., & Sadofsky, L. R. (2023). Ingredients of Vicks VapoRub inhibit rhinovirus-induced ATP release. Drugs in Context, 12, 1-18. https://doi.org/10.7573/dic.2023-3-2

Background: Over-the-counter therapies, such as Vicks VapoRub, are frequently used in the management of upper respiratory tract infection symptoms. Of these, acute cough is the most bothersome; however, the mechanisms involved have not been fully elu... Read More about Ingredients of Vicks VapoRub inhibit rhinovirus-induced ATP release.

Chronic cough—the limitation and advances in assessment techniques (2022)
Journal Article
Zhang, M., Sykes, D. L., Brindle, K., Sadofsky, L. R., & Morice, A. H. (2022). Chronic cough—the limitation and advances in assessment techniques. Journal of thoracic disease, 14(12), 5097-5119. https://doi.org/10.21037/jtd-22-874

Accurate and consistent assessments of cough are essential to advance the understanding of the mechanisms of cough and individualised the management of patients. Considerable progress has been made in this work. Here we reviewed the currently availab... Read More about Chronic cough—the limitation and advances in assessment techniques.

Outdoor Microplastic Analysis Using Inlet Filters from an NOx Regulatory Air Quality Monitoring Device (2022)
Journal Article
Jenner, L. C., Kureshi, R. R., White, D., Chapman, E., Sadofsky, L. R., & Rotchell, J. M. (2022). Outdoor Microplastic Analysis Using Inlet Filters from an NOx Regulatory Air Quality Monitoring Device. Atmosphere, 13(12), Article 2017. https://doi.org/10.3390/atmos13122017

Atmospheric microplastics (MPs) are a ubiquitous environmental contaminant of emerging concern. Sampling methods provide information relating to surface area concentration and MP characteristics, without direct comparison with routinely measured stan... Read More about Outdoor Microplastic Analysis Using Inlet Filters from an NOx Regulatory Air Quality Monitoring Device.

Microplastics in the surgical environment (2022)
Journal Article
Field, D. T., Green, J. L., Bennett, R., Jenner, L. C., Sadofsky, L., Chapman, E., Loubani, M., & Rotchell, J. M. (2022). Microplastics in the surgical environment. Environment International, 170, Article 107630. https://doi.org/10.1016/j.envint.2022.107630

Atmospheric microplastics (MPs) have been consistently detected within indoor and outdoor air samples. Locations with high human activity are reported to have high MP levels. The aim was to quantify and characterise the MPs present within the surgica... Read More about Microplastics in the surgical environment.

Nebivolol as a Potent TRPM8 Channel Blocker: A Drug-Screening Approach through Automated Patch Clamping and Ligand-Based Virtual Screening (2022)
Journal Article
Jahanfar, F., Sadofsky, L., Morice, A., & D’Amico, M. (2022). Nebivolol as a Potent TRPM8 Channel Blocker: A Drug-Screening Approach through Automated Patch Clamping and Ligand-Based Virtual Screening. Membranes, 12(10), Article 954. https://doi.org/10.3390/membranes12100954

Transient Receptor Potential Melastatin 8 (TRPM8) from the melastatin TRP channel subfamily is a non-selective Ca2+-permeable ion channel with multimodal gating which can be activated by low temperatures and cooling compounds, such as menthol and ici... Read More about Nebivolol as a Potent TRPM8 Channel Blocker: A Drug-Screening Approach through Automated Patch Clamping and Ligand-Based Virtual Screening.

ATP, an attractive target for the treatment of refractory chronic cough (2022)
Journal Article
Zhang, M., Sykes, D. L., Sadofsky, L. R., & Morice, A. H. (2022). ATP, an attractive target for the treatment of refractory chronic cough. Purinergic Signalling, 18, 289-305. https://doi.org/10.1007/s11302-022-09877-z

Chronic cough is the most common complaint in respiratory clinics. Most of them have identifiable causes and some may respond to common disease-modifying therapies. However, there are many patients whose cough lacks effective aetiologically targeted... Read More about ATP, an attractive target for the treatment of refractory chronic cough.

Detection of microplastics in human lung tissue using μFTIR spectroscopy (2022)
Journal Article
Jenner, L. C., Rotchell, J. M., Bennett, R. T., Cowen, M., Tentzeris, V., & Sadofsky, L. (2022). Detection of microplastics in human lung tissue using μFTIR spectroscopy. Science of the Total Environment, 831, Article 154907. https://doi.org/10.1016/j.scitotenv.2022.154907

Airborne microplastics (MPs) have been sampled globally, and their concentration is known to increase in areas of high human population and activity, especially indoors. Respiratory symptoms and disease following exposure to occupational levels of MP... Read More about Detection of microplastics in human lung tissue using μFTIR spectroscopy.

Outdoor atmospheric microplastics within the Humber region (United Kingdom): Quantification and chemical characterisation of deposited particles present (2022)
Journal Article
Jenner, L., Sadofsky, L., Danopoulos, E., Chapman, E., White, D., Jenkins, R., & Rotchell, J. M. (2022). Outdoor atmospheric microplastics within the Humber region (United Kingdom): Quantification and chemical characterisation of deposited particles present. Atmosphere, 13(2), Article 265. https://doi.org/10.3390/atmos13020265

Atmospheric microplastics (MPs) have been consistently captured within air samples on a global scale. Locations with high human activity are reported to have high MP levels. An urban sampling site in the Humber region (U.K.) has been sampled over a 1... Read More about Outdoor atmospheric microplastics within the Humber region (United Kingdom): Quantification and chemical characterisation of deposited particles present.

Household indoor microplastics within the Humber region (United Kingdom): quantification and chemical characterisation of particles present (2021)
Journal Article
Jenner, L., Sadofsky, L., Danopoulos, E., & Rotchell, J. M. (2021). Household indoor microplastics within the Humber region (United Kingdom): quantification and chemical characterisation of particles present. Atmospheric Environment, 259, Article 118512. https://doi.org/10.1016/j.atmosenv.2021.118512

Knowledge regarding the presence of suspended microplastics (MPs) within the air is lacking, especially indoors, yet the importance of indoor air quality and human health is rising. This study is the first to report MPs within multiple homes over a 6... Read More about Household indoor microplastics within the Humber region (United Kingdom): quantification and chemical characterisation of particles present.

Rhinovirus-16 increases ATP release in A549 cells without concomitant increase in production (2020)
Journal Article
Atkinson, S. K., Morice, A. H., & Sadofsky, L. R. (2020). Rhinovirus-16 increases ATP release in A549 cells without concomitant increase in production. ERJ Open Research, 6(4), Article 00159-2020. https://doi.org/10.1183/23120541.00159-2020

Human rhinovirus (RV) is the most common cause of upper respiratory tract infection (URTI) and chronic airway disease exacerbation. Cough is present in 50–80% of URTI cases, accompanied by heightened airway hypersensitivity, yet no effective treatmen... Read More about Rhinovirus-16 increases ATP release in A549 cells without concomitant increase in production.

Characterisation of a New Human Alveolar Macrophage-Like Cell Line (Daisy) (2019)
Journal Article
Sadofsky, L. R., Hayman, Y. A., Vance, J., Cervantes, J. L., Fraser, S. D., Wilkinson, H. N., Williamson, J. D., Hart, S. P., & Morice, A. H. (2019). Characterisation of a New Human Alveolar Macrophage-Like Cell Line (Daisy). Lung, 197(6), 687-698. https://doi.org/10.1007/s00408-019-00288-3

Purpose: There is currently no true macrophage cell line and in vitro experiments requiring these cells currently require mitogenic stimulation of a macrophage precursor cell line (THP-1) or ex vivo maturation of circulating primary monocytes. In thi... Read More about Characterisation of a New Human Alveolar Macrophage-Like Cell Line (Daisy).

N-cinnamoylanthranilates as human TRPA1 modulators: Structure-activity relationships and channel binding sites (2019)
Journal Article
Chandrabalan, A., McPhillie, M. J., Morice, A. H., Boa, A. N., & Sadofsky, L. R. (2019). N-cinnamoylanthranilates as human TRPA1 modulators: Structure-activity relationships and channel binding sites. European Journal of Medicinal Chemistry, 170, 141-156. https://doi.org/10.1016/j.ejmech.2019.02.074

The transient receptor potential ankyrin 1 (TRPA1) channel is a non-selective cation channel, which detects noxious stimuli leading to pain, itch and cough. However, the mechanism(s) of channel modulation by many of the known, non-reactive modulators... Read More about N-cinnamoylanthranilates as human TRPA1 modulators: Structure-activity relationships and channel binding sites.

Effect of high glucose on human alveolar macrophage phenotype and phagocytosis of mycobacteria (2018)
Journal Article
Vance, J., Santos, A., Sadofsky, L., Morice, A., & Cervantes, J. (2019). Effect of high glucose on human alveolar macrophage phenotype and phagocytosis of mycobacteria. Lung, 197(1), 89–94. https://doi.org/10.1007/s00408-018-0181-z

Purpose
Diabetes mellitus (DBM) reduces immunological activity and increases susceptibility to various infections, including tuberculosis (TB). Human alveolar macrophage (hAM) functions are altered in DBM.

Methods
To mimic hyperglycemic conditions i... Read More about Effect of high glucose on human alveolar macrophage phenotype and phagocytosis of mycobacteria.

Activation of mutated TRPA1 ion channel by resveratrol in human prostate cancer associated fibroblasts (CAF) (2017)
Journal Article
Vancauwenberghe, E., Noyer, L., Derouiche, S., Lemonnier, L., Gosset, P., Sadofsky, L. R., Mariot, P., Warnier, M., Bokhobza, A., Slomianny, C., Mauroy, B., Bonnal, J.-L., Dewailly, E., Delcourt, P., Allart, L., Desruelles, E., Prevarskaya, N., & Roudbaraki, M. (2017). Activation of mutated TRPA1 ion channel by resveratrol in human prostate cancer associated fibroblasts (CAF). Molecular Carcinogenesis, 56(8), 1851-1867. https://doi.org/10.1002/mc.22642

Previous studies showed the effects of resveratrol (RES) on several cancer cells, including prostate cancer (PCa) cell apoptosis without taking into consideration the impact of the tumor microenvironment (TME). The TME is composed of cancer cells, en... Read More about Activation of mutated TRPA1 ion channel by resveratrol in human prostate cancer associated fibroblasts (CAF).