All Outputs (12)

Cough hypersensitivity syndrome is an important clinical concept: A pro/con debate (2011)
Journal Article
Morice, A. H., McGarvey, L. P., & Dicpinigaitis, P. V. (2012). Cough hypersensitivity syndrome is an important clinical concept: A pro/con debate. Lung, 190(1), 3-9. https://doi.org/10.1007/s00408-011-9351-y

The major etiologies of chronic cough are generally accepted to consist of upper airway cough syndrome (formerly postnasal drip syndrome), eosinophilic airway inflammation (asthma, nonasthmatic eosinophilic bronchitis), and gastroesophageal reflux di... Read More about Cough hypersensitivity syndrome is an important clinical concept: A pro/con debate.

Chronic cough and esomeprazole: A double-blind placebo-controlled parallel study (2011)
Journal Article
Faruqi, S., Molyneux, I. D., Fathi, H., Wright, C., Thompson, R., & Morice, A. H. (2011). Chronic cough and esomeprazole: A double-blind placebo-controlled parallel study. Respirology : official journal of the Asian Pacific Society of Respirology, 16(7), 1150-1156. https://doi.org/10.1111/j.1440-1843.2011.02014.x

Background and objective: Gastro-oesophageal reflux has been implicated in the pathogenesis of chronic cough. Guidelines on management suggest a therapeutic trial of anti-reflux medication. Esomeprazole is a proton pump inhibitor licensed for the lon... Read More about Chronic cough and esomeprazole: A double-blind placebo-controlled parallel study.

Bronchoconstriction and airway remodeling [2] (2011)
Journal Article
Morjaria, J., Hart, S., & Morice, A. H. (2011). Bronchoconstriction and airway remodeling [2]. New England Journal of Medicine, 365(12), 1156-1157. https://doi.org/10.1056/NEJMc1107353

Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor-triggered ERK1/2 activation, calcium signalling and endocytosis (2011)
Journal Article
Botham, A., Guo, X., Xiao, Y. P., Morice, A. H., Compton, S., & Sadofsky, L. R. (2011). Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor-triggered ERK1/2 activation, calcium signalling and endocytosis. Biochemical Journal, 438(2), 359-367. https://doi.org/10.1042/BJ20101958

hPAR2 (human proteinase-activated receptor-2) is a member of the novel family of proteolytically activated GPCRs (G-protein-coupled receptors) termed PARs (proteinase-activated receptors). Previous pharmacological studies have found that activation o... Read More about Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor-triggered ERK1/2 activation, calcium signalling and endocytosis.

Gastro-oesophageal reflux, eosinophilic airway inflammation and chronic cough (2011)
Journal Article
Pacheco, A., Faro, V., Cobeta, I., Royuela, A., Molyneux, I., & Morice, A. H. (2011). Gastro-oesophageal reflux, eosinophilic airway inflammation and chronic cough. Respirology : official journal of the Asian Pacific Society of Respirology, 16(6), 994-999. https://doi.org/10.1111/j.1440-1843.2011.02010.x

Background and objective: Patients with eosinophilic airway inflammation (EAI) often show a therapeutic response to corticosteroids. Non-invasive methods of diagnosing EAI are potentially useful in guiding therapy, particularly in conditions such as... Read More about Gastro-oesophageal reflux, eosinophilic airway inflammation and chronic cough.

Effect of bitter tastants on human bronchi (2011)
Journal Article
Morice, A. H., Bennett, R. T., Chaudhry, M. A., Cowen, M. E., Griffin, S. C., & Loubani, M. (2011). Effect of bitter tastants on human bronchi. Nature Medicine, 17(7), 775. https://doi.org/10.1038/nm0711-775

Serum LDH in chronic cough: A potential marker of airway inflammation (2011)
Journal Article
Faruqi, S., Wilmot, R., Wright, C., & Morice, A. H. (2012). Serum LDH in chronic cough: A potential marker of airway inflammation. Clinical Respiratory Journal, 6(2), 81-87. https://doi.org/10.1111/j.1752-699X.2011.00250.x

Introduction and Objectives: Lactate dehydrogenase (LDH) is found in almost all tissues of the body and five different isoenzymes are known (LDH-1 to LDH-5). LDH can be elevated in many pathological conditions. We have observed serum LDH to be increa... Read More about Serum LDH in chronic cough: A potential marker of airway inflammation.

Airway reflux, cough and respiratory disease (2011)
Journal Article
Molyneux, I. D., & Morice, A. H. (2011). Airway reflux, cough and respiratory disease. Therapeutic Advances in Chronic Disease, 2(4), 237-248. https://doi.org/10.1177/2040622311406464

It is increasingly accepted that the effects of gastro-oesophageal reflux are not limited to the gastrointestinal tract. The adjacent respiratory structures are also at risk from material ejected from the proximal oesophagus as a result of the failur... Read More about Airway reflux, cough and respiratory disease.

N-linked glycosylation regulates human proteinase-activated receptor-1 cell surface expression and disarming via neutrophil proteinases and thermolysin (2011)
Journal Article
Xiao, Y. P., Morice, A. H., Compton, S. J., & Sadofsky, L. (2011). N-linked glycosylation regulates human proteinase-activated receptor-1 cell surface expression and disarming via neutrophil proteinases and thermolysin. Journal of Biological Chemistry, 286(26), 22991-23002. https://doi.org/10.1074/jbc.M110.204271

Proteinase-activated receptor 1 (PAR1) induces activation of platelet and vascular cells after proteolytic cleavage of its extracellular N terminus by thrombin. In pathological situations, other proteinases may be generated in the circulation and mig... Read More about N-linked glycosylation regulates human proteinase-activated receptor-1 cell surface expression and disarming via neutrophil proteinases and thermolysin.

Gastroesophageal reflux and idiopathic pulmonary fibrosis: A prospective study (2011)
Journal Article
Fahim, A., Dettmar, P. W., Morice, A. H., & Hart, S. P. (2011). Gastroesophageal reflux and idiopathic pulmonary fibrosis: A prospective study. 00 Journal not listed, 47(4), 200-205. https://doi.org/10.3390/medicina47040028

Background and Objective: Idiopathic pulmonary fibrosis (IPF) is the most common of the idiopathic interstitial pneumonias. There is evidence of the increased prevalence of gastroesophageal reflux disease in patients with IPF. The aim of this prospec... Read More about Gastroesophageal reflux and idiopathic pulmonary fibrosis: A prospective study.

Review article: Reflux in cough and airway disease (2011)
Journal Article
Morice, A. H. (2011). Review article: Reflux in cough and airway disease. Alimentary Pharmacology and Therapeutics, 33(SUPPL. 1), 48-52. https://doi.org/10.1111/j.1365-2036.2011.4581.x

Chronic cough was previously thought to be attributed to three main aetiologies; asthma, reflux and postnasal drip. There is little to differentiate these three different diagnoses in the patients with chronic cough in terms of histology, cytokine pr... Read More about Review article: Reflux in cough and airway disease.

Relationship Between Gastro-Oesophageal Reflux and Airway Diseases: The Airway Reflux Paradigm (2011)
Journal Article
Pacheco-Galván, A., Hart, S. P., & Morice, A. H. (2011). Relationship Between Gastro-Oesophageal Reflux and Airway Diseases: The Airway Reflux Paradigm. Archivos de Bronconeumología, 47(4), 195-203. https://doi.org/10.1016/S1579-2129%2811%2970046-5

Our understanding of the relationship between gastro-oesophageal reflux and respiratory disease has recently undergone important changes. The previous paradigm of airway reflux as synonymous with the classic gastro-oesophageal reflux disease (GORD) c... Read More about Relationship Between Gastro-Oesophageal Reflux and Airway Diseases: The Airway Reflux Paradigm.