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All Outputs (211)

Chronic cough associated with Crohn's disease (2010)
Journal Article
Faruqi, S., Avery, G., & Morice, A. H. (2010). Chronic cough associated with Crohn's disease. Cough, 6(1), https://doi.org/10.1186/1745-9974-6-6

A 62-year-old man presented with chronic dry cough. He was known to have Crohn's disease which was in remission. A plain chest radiograph demonstrated bilateral apical infiltrates. A HRCT of the chest showed normal proximal airways. Stenosis of mediu... Read More about Chronic cough associated with Crohn's disease.

TRPA1 agonists evoke coughing in guinea pig and human volunteers (2009)
Journal Article
Birrell, M. A., Belvisi, M. G., Grace, M., Sadofsky, L., Faruqi, S., Hele, D. J., Maher, S. A., Freund-Michel, V., & Morice, A. H. (2009). TRPA1 agonists evoke coughing in guinea pig and human volunteers. American Journal of Respiratory and Critical Care Medicine, 180(11), 1042-1047. https://doi.org/10.1164/rccm.200905-0665OC

Rationale: Cough is the most frequent reason for consultation with a family doctor, or with a general or respiratory physician. Treatment options are limited and one meta-analysis concluded that over-the-counter remedies are ineffective. There is als... Read More about TRPA1 agonists evoke coughing in guinea pig and human volunteers.

The online Cough Clinic: Developing guideline-based diagnosis and advice (2009)
Journal Article
Dettmar, P. W., Strugala, V., Fathi, H., Dettmar, H. J., Wright, C., & Morice, A. H. (2009). The online Cough Clinic: Developing guideline-based diagnosis and advice. European respiratory journal, 34(4), 819-824. https://doi.org/10.1183/09031936.00126908

The aim of the present study was make chronic cough guidelines more practical and user friendly by developing an internet-based interactive diagnostic questionnaire for chronic cough. A prospective cohort study of chronic cough sufferers was conducte... Read More about The online Cough Clinic: Developing guideline-based diagnosis and advice.

Combination of sitaxentan and tadalafil for idiopathic pulmonary arterial hypertension following relapse on bosentan (2009)
Journal Article
Faruqi, S., Fathi, H., & Morice, A. H. (2010). Combination of sitaxentan and tadalafil for idiopathic pulmonary arterial hypertension following relapse on bosentan. International journal of cardiology, 144(3), e43-e45. https://doi.org/10.1016/j.ijcard.2008.12.065

Sitaxentan, a highly-selective endothelin receptor antagonist (ETRA) and bosentan a non-selective ETRA are both approved for the treatment of idiopathic pulmonary arterial hypertension (iPAH). Sildenafil is a phosphodiesterase-5 (PDE-5) inhibitor use... Read More about Combination of sitaxentan and tadalafil for idiopathic pulmonary arterial hypertension following relapse on bosentan.

Transient receptor potential vanilloid-1-mediated calcium responses are inhibited by the alkylamine antihistamines dexbrompheniramine and chlorpheniramine (2008)
Journal Article
Sadofsky, L. R., Campi, B., Trevisani, M., Compton, S. J., & Morice, A. H. (2008). Transient receptor potential vanilloid-1-mediated calcium responses are inhibited by the alkylamine antihistamines dexbrompheniramine and chlorpheniramine. Experimental Lung Research, 34(10), 681-693. https://doi.org/10.1080/01902140802339623

American guidelines, unlike European guidelines, support the use of antihistamines as a first line of treatment for some causes of chronic cough. Transient receptor potential vanilloid-1 (TRPV1) is an ion channel activated by the tussive agents capsa... Read More about Transient receptor potential vanilloid-1-mediated calcium responses are inhibited by the alkylamine antihistamines dexbrompheniramine and chlorpheniramine.

The Leicester Cough Monitor: a semi-automated, semi-validated cough detection system? Reply (2008)
Journal Article
Birring, S. S., Mann, V. M., Matos, S., Yousaf, N., Wood, C., Fleming, T., Evans, D. H., Morice, A. H., & Pavord, I. D. (2008). The Leicester Cough Monitor: a semi-automated, semi-validated cough detection system? Reply. European respiratory journal, 32(2), 530-531. https://doi.org/10.1183/09031936.00060808

K. McGuinness and colleagues request further details regarding the validation of the Leicester Cough Monitor (LCM) over 24 h. This was not possible during our study because of limitations in battery life 1. Therefore, we compared automated and manual... Read More about The Leicester Cough Monitor: a semi-automated, semi-validated cough detection system? Reply.

Inflammatory mediators modulate thrombin and cathepsin-G signaling in human bronchial fibroblasts by inducing expression of proteinase-activated receptor-4 (2007)
Journal Article
Ramachandran, R., Sadofsky, L., Xiao, Y., Botham, A., Cowen, M., Morice, A., & Compton, S. J. (2007). Inflammatory mediators modulate thrombin and cathepsin-G signaling in human bronchial fibroblasts by inducing expression of proteinase-activated receptor-4. American journal of physiology. Lung cellular and molecular physiology, 292(3), L788-L798. https://doi.org/10.1152/ajplung.00226.2006

Human lung fibroblasts express proteinase-activated receptor-1 (PAR 1 ), PAR 2 and PAR 3 , but not PAR 4 . Because PAR 2 has inflammatory effects on human primary bronchial fibroblasts (HPBF), we asked 1) whether the inflammatory mediators TNF-α and... Read More about Inflammatory mediators modulate thrombin and cathepsin-G signaling in human bronchial fibroblasts by inducing expression of proteinase-activated receptor-4.

Letter to the editor (2004)
Journal Article
Clark, A. L., & Morice, A. (2004). Letter to the editor. European journal of heart failure, 6(4), 511. https://doi.org/10.1016/j.ejheart.2004.04.001

Re: Schroder D, Weiser M, Klein P. Efficacy of a homeopathic Crataegus preparation compared with usual therapy for mild (NYHA II) cardiac insufficiency: results of an observational cohort study. Eur J Heart Fail 2003;5:319–26