All Outputs (5)

Hippo Signaling: Key Emerging Pathway in Cellular and Whole-Body Metabolism (2018)
Journal Article
Ardestani, A., Lupse, B., & Maedler, K. (2018). Hippo Signaling: Key Emerging Pathway in Cellular and Whole-Body Metabolism. Trends in Endocrinology & Metabolism, 29(7), 492-509. https://doi.org/10.1016/j.tem.2018.04.006

The evolutionarily conserved Hippo pathway is a key regulator of organ size and tissue homeostasis. Its dysregulation is linked to multiple pathological disorders. In addition to regulating development and growth, recent studies show that Hippo pathw... Read More about Hippo Signaling: Key Emerging Pathway in Cellular and Whole-Body Metabolism.

mTORC2 Signaling: A Path for Pancreatic β Cell's Growth and Function (2018)
Journal Article
Yuan, T., Lupse, B., Maedler, K., & Ardestani, A. (2018). mTORC2 Signaling: A Path for Pancreatic β Cell's Growth and Function. Journal of Molecular Biology, 430(7), 904-918. https://doi.org/10.1016/j.jmb.2018.02.013

The mechanistic target of rapamycin (mTOR) signaling pathway is an evolutionary conserved pathway that senses signals from nutrients and growth factors to regulate cell growth, metabolism and survival. mTOR acts in two biochemically and functionally... Read More about mTORC2 Signaling: A Path for Pancreatic β Cell's Growth and Function.

mTORC1 Signaling: A Double-Edged Sword in Diabetic β Cells (2017)
Journal Article
Ardestani, A., Lupse, B., Kido, Y., Leibowitz, G., & Maedler, K. (2018). mTORC1 Signaling: A Double-Edged Sword in Diabetic β Cells. Cell Metabolism, 27(2), 314-331. https://doi.org/10.1016/j.cmet.2017.11.004

The mechanistic target of rapamycin complex 1 (mTORC1) is a central regulator of metabolic and nutrient cues that integrates environmental inputs into downstream signaling pathways to control cellular metabolism, growth, and survival. While numerous... Read More about mTORC1 Signaling: A Double-Edged Sword in Diabetic β Cells.

The Hippo signaling pathway in pancreatic β-cells: Functions and regulations (2017)
Journal Article
Ardestani, A., & Maedler, K. (2018). The Hippo signaling pathway in pancreatic β-cells: Functions and regulations. Endocrine Reviews, 39(1), 21-35. https://doi.org/10.1210/er.2017-00167

Hippo signaling is an evolutionarily conserved pathway that critically regulates development and homeostasis of various tissues in response to a wide range of extracellular and intracellular signals. As an emerging important player in many diseases,... Read More about The Hippo signaling pathway in pancreatic β-cells: Functions and regulations.

MST1: a promising therapeutic target to restore functional beta cell mass in diabetes (2016)
Journal Article
Ardestani, A., & Maedler, K. (2016). MST1: a promising therapeutic target to restore functional beta cell mass in diabetes. Diabetologia, 59(9), 1843-1849. https://doi.org/10.1007/s00125-016-3892-9

The loss of insulin-producing beta cells by apoptosis is a hallmark of all forms of diabetes mellitus. Strategies to prevent beta cell apoptosis and dysfunction are urgently needed to restore the insulin-producing cells and to prevent severe diabetes... Read More about MST1: a promising therapeutic target to restore functional beta cell mass in diabetes.