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The Hippo signaling pathway in pancreatic β-cells: Functions and regulations

Ardestani, Amin; Maedler, Kathrin

Authors

Kathrin Maedler



Abstract

Hippo signaling is an evolutionarily conserved pathway that critically regulates development and homeostasis of various tissues in response to a wide range of extracellular and intracellular signals. As an emerging important player in many diseases, the Hippo pathway is also involved in the pathophysiology of diabetes on the level of the pancreatic islets. Multiple lines of evidence uncover the importance of Hippo signaling in pancreas development as well as in the regulation of β-cell survival, proliferation, and regeneration. Hippo therefore represents a potential target for therapeutic agents designed to improve β-cell function and survival in diabetes. In this review, we summarize recent data on the regulation of the Hippo signaling pathway in the pancreas/in pancreatic islets, its functions on β-cell homeostasis in physiology and pathophysiology, and its contribution toward diabetes progression. The current knowledge related to general mechanisms of action and the possibility of exploiting the Hippo pathway for therapeutic approaches to block β-cell failure in diabetes is highlighted.

Citation

Ardestani, A., & Maedler, K. (2018). The Hippo signaling pathway in pancreatic β-cells: Functions and regulations. Endocrine Reviews, 39(1), 21-35. https://doi.org/10.1210/er.2017-00167

Journal Article Type Review
Acceptance Date Oct 12, 2017
Online Publication Date Oct 18, 2017
Publication Date Feb 1, 2018
Deposit Date Jan 4, 2024
Journal Endocrine Reviews
Print ISSN 0163-769X
Electronic ISSN 1945-7189
Publisher Oxford University Press
Peer Reviewed Peer Reviewed
Volume 39
Issue 1
Pages 21-35
DOI https://doi.org/10.1210/er.2017-00167
Public URL https://hull-repository.worktribe.com/output/4461656