Abnormal acinar–β-cell crosstalk in type 2 diabetes

Geravandi, Shirin; Ardestani, Amin

Abstract

Cellular crosstalk plays a vital role in maintaining pancreas homeostasis. Recently, in Cell Metabolism, Basile et al. demonstrated that aberrant upregulation of acinar-cell-specific pancreatic elastase CELA3B within endocrine islets reduces β-cell viability in type 2 diabetes (T2D). This identifies detrimental acinar–β-cell crosstalk as a novel pathogenic mechanism in diabetes.

Citation

Geravandi, S., & Ardestani, A. (2023). Abnormal acinar–β-cell crosstalk in type 2 diabetes. Trends in Endocrinology & Metabolism, 34(11), 685-687. https://doi.org/10.1016/j.tem.2023.08.006

• Journal Article Type: Commentary
• Acceptance Date: Aug 7, 2023
• Online Publication Date: Aug 19, 2023
• Publication Date: Nov 1, 2023
• Deposit Date: Jan 3, 2024
• Journal: Trends in Endocrinology and Metabolism
• Print ISSN: 1043-2760
• Electronic ISSN: 1879-3061
• Publisher: Cell Press
• Peer Reviewed: Peer Reviewed
• Volume: 34
• Issue: 11
• Pages: 685-687
• DOI: https://doi.org/10.1016/j.tem.2023.08.006
• Public URL: https://hull-repository.worktribe.com/output/4460704