All Outputs (8)

Feasibility of delivering supervised exercise training following surgical resection and during adjuvant chemotherapy for pancreatic ductal adenocarcinoma (PRECISE): a case series (2023)
Journal Article
Brown, M., O’Connor, D., Turkington, R., Eatock, M., Vince, R., Hulme, C., …Prue, G. (2023). Feasibility of delivering supervised exercise training following surgical resection and during adjuvant chemotherapy for pancreatic ductal adenocarcinoma (PRECISE): a case series. BMC Sports Science, Medicine and Rehabilitation, 15(1), Article 116. https://doi.org/10.1186/s13102-023-00722-3

Introduction: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive neoplasm, with surgical resection and adjuvant chemotherapy the only curative treatment. Treatment-related toxicities place a considerable burden on patients although exercise tra... Read More about Feasibility of delivering supervised exercise training following surgical resection and during adjuvant chemotherapy for pancreatic ductal adenocarcinoma (PRECISE): a case series.

Abstract A020: Calcitonin receptor-like receptor is expressed in blood vessels in clear cell renal cell carcinoma and upregulated in endothelial cells co-cultured with tumor cells (2023)
Presentation / Conference Contribution
Morfitt, M. A., Greenman, J., Maraveyas, A., Harris, A. L., & Nikitenko, L. L. (2023). Abstract A020: Calcitonin receptor-like receptor is expressed in blood vessels in clear cell renal cell carcinoma and upregulated in endothelial cells co-cultured with tumor cells. Cancer Research, 83(16_Supplement), A020-A020. https://doi.org/10.1158/1538-7445.kidney23-a020

Introduction. Clear cell renal cell carcinoma (ccRCC) is a highly vascularized and clinically aggressive kidney cancer, with high rates of metastasis and recurrence after cytoreductive nephrectomy. ccRCC can be treated with anti-angiogenic drugs, how... Read More about Abstract A020: Calcitonin receptor-like receptor is expressed in blood vessels in clear cell renal cell carcinoma and upregulated in endothelial cells co-cultured with tumor cells.

Abstract B001: Calcitonin receptor-like receptor agonists induce p44/42 MAPK phosphorylation in VEGF-A-stimulated human blood endothelial cells after bevacizumab treatment (2023)
Presentation / Conference Contribution
Morfitt, M. A., Greenman, J., Maraveyas, A., & Nikitenko, L. L. (2023). Abstract B001: Calcitonin receptor-like receptor agonists induce p44/42 MAPK phosphorylation in VEGF-A-stimulated human blood endothelial cells after bevacizumab treatment. Cancer Research, 83(16_Supplement), B001-B001. https://doi.org/10.1158/1538-7445.kidney23-b001

Introduction. Clear cell renal cell carcinoma (ccRCC) is a highly vascularized and clinically aggressive cancer. In the UK, there are around 9000 diagnoses and 3000 deaths annually. Targeted therapies that inhibit angiogenic regulators, such as bevac... Read More about Abstract B001: Calcitonin receptor-like receptor agonists induce p44/42 MAPK phosphorylation in VEGF-A-stimulated human blood endothelial cells after bevacizumab treatment.

Quantitative proteomics of pancreatic cyst fluid for early diagnosis of cancer. (2023)
Presentation / Conference Contribution
Nikitenko, L. L., Manolis, D., O'Brien, D. P., Adekeye, A., Kessler, B. M., Collins, C., Kramer, H., Chang, D., & Maraveyas, A. Quantitative proteomics of pancreatic cyst fluid for early diagnosis of cancer. Presented at The London Pancreas Workshop 2023, London, United Kingdom

In our EARLY DIAgnosis of PAncreatic Cancer (EARLY DIAPAC) study, we aim to analyse molecular changes or “signatures” associated with early stages of pancreatic carcinogenesis by using the combination of: (i) Label-Free Quantitative Proteomics (LFQP)... Read More about Quantitative proteomics of pancreatic cyst fluid for early diagnosis of cancer..

Towards optimal use of antithrombotic therapy of people with cancer at the end of life: A research protocol for the development and implementation of the SERENITY shared decision support tool (2023)
Journal Article
Goedegebuur, J., Abbel, D., Accassat, S., Achterberg, W. P., Akbari, A., Arfuch, V. M., …Noble, S. I. (2023). Towards optimal use of antithrombotic therapy of people with cancer at the end of life: A research protocol for the development and implementation of the SERENITY shared decision support tool. Thrombosis Research, 228, 54-60. https://doi.org/10.1016/j.thromres.2023.05.008

BACKGROUND: Even though antithrombotic therapy has probably little or even negative effects on the well-being of people with cancer during their last year of life, deprescribing antithrombotic therapy at the end of life is rare in practice. It is oft... Read More about Towards optimal use of antithrombotic therapy of people with cancer at the end of life: A research protocol for the development and implementation of the SERENITY shared decision support tool.

Abstract 224: Establishing de novo platform for whole genome sequencing of pancreatic cyst fluid for early detection and diagnosis of pancreatic cancer (2023)
Presentation / Conference Contribution
Adekeye, A., Haque, F., Ettelaie, C., Nikitenko, L., & Maraveyas, A. (2023). Abstract 224: Establishing de novo platform for whole genome sequencing of pancreatic cyst fluid for early detection and diagnosis of pancreatic cancer. Cancer Research, 83(7_Supplement), 224-224. https://doi.org/10.1158/1538-7445.am2023-224

Background: Pancreatic cancer (PC) is a leading cause of cancer-related deaths globally. Accurate PC detection at early or premalignant stage, when surgery is effective, would increase survival rates and prevent unnecessary surgery or surveillance. A... Read More about Abstract 224: Establishing de novo platform for whole genome sequencing of pancreatic cyst fluid for early detection and diagnosis of pancreatic cancer.

Biological function and clinical implication of coagulation proteins during malignant transformation of pancreatic cells (2023)
Thesis
Haque, F. Biological function and clinical implication of coagulation proteins during malignant transformation of pancreatic cells. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4371279

The premalignant pancreatic cellular genotype can remain stable for years before rapid malignant transformation, often associated with inflammation. Tissue factor (TF) is an inflammatory modulator regulated by factor VIIa (fVIIa) for its levels and a... Read More about Biological function and clinical implication of coagulation proteins during malignant transformation of pancreatic cells.

Validation of the HULL Score clinical prediction rule for unsuspected pulmonary embolism in ambulatory cancer patients (2023)
Journal Article
Haque, F., Ryde, J., Broughton, L., Huang, C., Sethi, S., Stephens, A., …Maraveyas, A. (2023). Validation of the HULL Score clinical prediction rule for unsuspected pulmonary embolism in ambulatory cancer patients. ERJ Open Research, 9(3), Article 00651-2022. https://doi.org/10.1183/23120541.00651-2022

Background Clinical prediction rules (CPRs) developed to predict adverse outcomes of suspected pulmonary embolism (PE) and facilitate outpatient management have limitations in discriminating outcomes for ambulatory cancer patients with unsuspected PE... Read More about Validation of the HULL Score clinical prediction rule for unsuspected pulmonary embolism in ambulatory cancer patients.