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All Outputs (62)

Home-based high intensity interval training in patients with intermittent claudication: a systematic review protocol (2024)
Journal Article
Prosser, J., Staniland, T., Harwood, A., Ravindhran, B., McGregor, G., Huang, C., Twiddy, M., Nicholls, A., Ingle, L., Long, J., Chetter, I., & Pymer, S. (2024). Home-based high intensity interval training in patients with intermittent claudication: a systematic review protocol. Journal of Vascular Societies Great Britain and Ireland, 3(3), 155-159. https://doi.org/10.54522/jvsgbi.2024.103

Introduction: The aim of this systematic review is to consider the evidence base for home-based high intensity interval training (HIIT) in patients with intermittent claudication (IC). Prior knowledge of the evidence base suggests that there may be l... Read More about Home-based high intensity interval training in patients with intermittent claudication: a systematic review protocol.

Improving the Detection, Assessment, Management and Prevention of Delirium in Hospices (the DAMPen-D study): Feasibility study of a flexible and scalable implementation strategy to deliver guideline-adherent delirium care (2024)
Journal Article
Jackson, G. P., Jackson, C., Boland, J. W., Featherstone, I., Huang, C., Ogden, M., …Johnson, M. J. (2024). Improving the Detection, Assessment, Management and Prevention of Delirium in Hospices (the DAMPen-D study): Feasibility study of a flexible and scalable implementation strategy to deliver guideline-adherent delirium care. Palliative medicine, 38(4), 447-456. https://doi.org/10.1177/02692163241236325

Background: Delirium is a complex condition, stressful for all involved. Although highly prevalent in palliative care settings, it remains underdiagnosed and associated with poor outcomes. Guideline-adherent delirium care may improve its detection, a... Read More about Improving the Detection, Assessment, Management and Prevention of Delirium in Hospices (the DAMPen-D study): Feasibility study of a flexible and scalable implementation strategy to deliver guideline-adherent delirium care.

Association between protein intake and muscle wasting in critically ill children: a prospective cohort study (2024)
Journal Article
Tume, L. N., Simons, C., Latten, L., Huang, C., Comfort, P., Compton, V., …Valla, F. V. (in press). Association between protein intake and muscle wasting in critically ill children: a prospective cohort study. Journal of Parenteral and Enteral Nutrition, https://doi.org/10.1002/jpen.2627

Background: Survival from pediatric critical illness in high-income countries is high, and the focus now must be on optimizing the recovery of survivors. Muscle mass wasting during critical illness is problematic, so identifying factors that may redu... Read More about Association between protein intake and muscle wasting in critically ill children: a prospective cohort study.

A randomised controlled trial of Pre-Operative Oncotype DX testing in early-stage breast cancer (PRE-DX study) - Study protocol (2024)
Journal Article
Northgraves, M., Cohen, J., Harvey, J., Huang, C., Palmieri, C., Pinder, S., …Cain, H. (2024). A randomised controlled trial of Pre-Operative Oncotype DX testing in early-stage breast cancer (PRE-DX study) - Study protocol. PLoS ONE, 19(3), Article e0300339. https://doi.org/10.1371/journal.pone.0300339

Background
The Oncotype DX® Breast Recurrence Score assay can guide recommendations made to patients with oestrogen receptor positive (ER+), human epidermal growth factor receptor 2 negative (HER2-) breast cancer regarding post-surgery adjuvant the... Read More about A randomised controlled trial of Pre-Operative Oncotype DX testing in early-stage breast cancer (PRE-DX study) - Study protocol.

High INtensity Interval Training in pATiEnts with Intermittent Claudication: A Qualitative Acceptability Study (2024)
Journal Article
Pymer, S., Harwood, A., Ibeggazene, S., McGregor, G., Huang, C., Nicholls, A., Ingle, L., Long, J., Rooms, M., Chetter, I. C., & Twiddy, M. (2024). High INtensity Interval Training in pATiEnts with Intermittent Claudication: A Qualitative Acceptability Study. Annals of vascular surgery, 102, 17-24. https://doi.org/10.1016/j.avsg.2023.11.043

Background: A novel high-intensity interval training (HIIT) program has demonstrated feasibility for patients with intermittent claudication (IC). The aim of this study was to explore patient perspectives of the HIIT program to inform refinement and... Read More about High INtensity Interval Training in pATiEnts with Intermittent Claudication: A Qualitative Acceptability Study.

Antithrombotic drugs for cardiovascular risk reduction in patients with lower limb peripheral arterial disease: protocol for a systematic review and network meta-analysis of randomised controlled trials (2023)
Journal Article
Sidebottom, D. B., Huang, C., Carradice, D., Holt, P. J., John-Pierre, K., & Roy, I. N. (2023). Antithrombotic drugs for cardiovascular risk reduction in patients with lower limb peripheral arterial disease: protocol for a systematic review and network meta-analysis of randomised controlled trials. BMJ open, 13(8), Article e072355. https://doi.org/10.1136/bmjopen-2023-072355

INTRODUCTION: The optimal antithrombotic regimen to reduce the risk of vascular events in patients with peripheral arterial disease (PAD) is contentious. This systematic review and network meta-analysis (NMA) aims to define the relative efficacy and... Read More about Antithrombotic drugs for cardiovascular risk reduction in patients with lower limb peripheral arterial disease: protocol for a systematic review and network meta-analysis of randomised controlled trials.

Biomarker-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection: statistical analysis plan for the BATCH trial and PRECISE sub-study (2023)
Journal Article
Schoenbuchner, S. M., Huang, C., Waldron, C. A., Thomas-Jones, E., Hood, K., Carrol, E. D., & Pallmann, P. (2023). Biomarker-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection: statistical analysis plan for the BATCH trial and PRECISE sub-study. Trials, 24(1), Article 364. https://doi.org/10.1186/s13063-022-06956-9

Introduction: The BATCH trial is a multi-centre randomised controlled trial to compare procalcitonin-guided management of severe bacterial infection in children with current management. PRECISE is a mechanistic sub-study embedded into the BATCH trial... Read More about Biomarker-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection: statistical analysis plan for the BATCH trial and PRECISE sub-study.

Improving asthma care through implementation of the SENTINEL programme: findings from the pilot site (2023)
Journal Article
Crooks, M. G., Crowther, L., Cummings, H., Cohen, J., Huang, C., Pitel, L., Pearson, M., Morice, A., Turgoose, J., Faruqi, S., Watt, M., Morris, T., & Xu, Y. (2023). Improving asthma care through implementation of the SENTINEL programme: findings from the pilot site. ERJ Open Research, 9(3), Article 00685-2022. https://doi.org/10.1183/23120541.00685-2022

Aim: Short-acting β2-agonist (SABA) overuse adversely impacts asthma-related outcomes and the environment. The SABA rEductioN Through ImplemeNting Hull asthma guidELines (SENTINEL) programme aims to reduce SABA overuse through supported implementatio... Read More about Improving asthma care through implementation of the SENTINEL programme: findings from the pilot site.

The Cognitive Daisy (COG-D) for improving care for residents with dementia in care homes: protocol of a feasibility RCT (2023)
Journal Article
Pollux, P. M., Surr, C., Cohen, J., Huang, C., Wolverson, E., Mountain, P., …Hudson, J. M. (2023). The Cognitive Daisy (COG-D) for improving care for residents with dementia in care homes: protocol of a feasibility RCT. Pilot and Feasibility Studies, 9(1), Article 34. https://doi.org/10.1186/s40814-023-01256-8

Background: Cognitive problems associated with dementia affect a large proportion of older adults living in residential care. Knowledge of cognitive impairments is important for providing person-centred care (PCC). The impact of specific cognitive im... Read More about The Cognitive Daisy (COG-D) for improving care for residents with dementia in care homes: protocol of a feasibility RCT.

Validation of the HULL Score clinical prediction rule for unsuspected pulmonary embolism in ambulatory cancer patients (2023)
Journal Article
Haque, F., Ryde, J., Broughton, L., Huang, C., Sethi, S., Stephens, A., …Maraveyas, A. (2023). Validation of the HULL Score clinical prediction rule for unsuspected pulmonary embolism in ambulatory cancer patients. ERJ Open Research, 9(3), Article 00651-2022. https://doi.org/10.1183/23120541.00651-2022

Background Clinical prediction rules (CPRs) developed to predict adverse outcomes of suspected pulmonary embolism (PE) and facilitate outpatient management have limitations in discriminating outcomes for ambulatory cancer patients with unsuspected PE... Read More about Validation of the HULL Score clinical prediction rule for unsuspected pulmonary embolism in ambulatory cancer patients.

Telemedicine in addictions: Feasibility randomised controlled trial (2023)
Journal Article
Mayet, S., Gledhill, A., McCaw, I., Hashmani, Z., Drozdova, Z., Arshad, S., Shahbaz, S., Huang, C., & Phillips, T. (2023). Telemedicine in addictions: Feasibility randomised controlled trial. Heroin Addiction and Related Clinical Problems, 25(3), 27-36

Background. Opioid dependence is high risk. Opioid agonist treatment (OAT) improves outcomes and reduces deaths. Nonattendance at addiction specialist prescribers who monitor OAT worsens outcomes. Telemedicine has been shown to improve attendance wit... Read More about Telemedicine in addictions: Feasibility randomised controlled trial.

Assessment of the diagnostic accuracy of automated ankle brachial pressure index devices in patients with diagnosed or suspected peripheral arterial disease: protocol for a systematic review and meta-analysis (2022)
Journal Article
Walshaw, J., Lathan, R., Huang, C., Staniland, T., Chetter, I., & Pymer, S. (2023). Assessment of the diagnostic accuracy of automated ankle brachial pressure index devices in patients with diagnosed or suspected peripheral arterial disease: protocol for a systematic review and meta-analysis. Journal of Vascular Societies Great Britain and Ireland, 2(2), 91-96. https://doi.org/10.54522/jvsgbi.2022.053

Background: The ankle brachial pressure index (ABPI) is a common diagnostic tool used in the assessment of peripheral arterial disease (PAD). The Doppler ultrasound technique is regarded as the gold-standard method for ABPI measurement; however, time... Read More about Assessment of the diagnostic accuracy of automated ankle brachial pressure index devices in patients with diagnosed or suspected peripheral arterial disease: protocol for a systematic review and meta-analysis.

Paediatric early warning systems: Not a simple answer to a complex question (2022)
Journal Article
Roland, D., Powell, C., Lloyd, A., Trubey, R., Tume, L., Sefton, G., Huang, C., Taiyari, K., Strange, H., Jacob, N., Thomas-Jones, E., Hood, K., & Allen, D. (2023). Paediatric early warning systems: Not a simple answer to a complex question. Archives of Disease in Childhood, 108(5), 338-343. https://doi.org/10.1136/archdischild-2022-323951

Paediatric early warning systems (PEWS) to reduce in-hospital mortality have been a laudable endeavour. Evaluation of their impact has rarely examined the internal validity of the components of PEWS in achieving desired outcomes. We highlight the ass... Read More about Paediatric early warning systems: Not a simple answer to a complex question.

A prospective registry-based cohort study of the diagnosis and management of acute leukaemia in pregnancy: Study protocol (2022)
Journal Article
Northgraves, M., Allsup, D., Cohen, J., Huang, C., Turgoose, J., & Ali, S. (2022). A prospective registry-based cohort study of the diagnosis and management of acute leukaemia in pregnancy: Study protocol. PLoS ONE, 17(2), Article e0263195. https://doi.org/10.1371/journal.pone.0263195

Background
Acute leukaemias (AL) are aggressive but potentially curable blood cancers that can potentially affect women of childbearing age. When a pregnancy is complicated by a diagnosis of AL, clinicians face a complex dilemma: to balance risking... Read More about A prospective registry-based cohort study of the diagnosis and management of acute leukaemia in pregnancy: Study protocol.

Biomarker-guided duration of Antibiotic Treatment in Children Hospitalised with confirmed or suspected bacterial infection (BATCH): Protocol for a randomised controlled trial (2022)
Journal Article
Waldron, C. A., Thomas-Jones, E., Bernatoniene, J., Brookes-Howell, L., Faust, S. N., Faust, S. N., …Carrol, E. D. (2022). Biomarker-guided duration of Antibiotic Treatment in Children Hospitalised with confirmed or suspected bacterial infection (BATCH): Protocol for a randomised controlled trial. BMJ open, 12(1), Article e047490. https://doi.org/10.1136/bmjopen-2020-047490

Introduction Procalcitonin (PCT) is a biomarker more specific for bacterial infection and responds quicker than other commonly used biomarkers such as C reactive protein, but is not routinely used in the National Health Service (NHS). Studies mainly... Read More about Biomarker-guided duration of Antibiotic Treatment in Children Hospitalised with confirmed or suspected bacterial infection (BATCH): Protocol for a randomised controlled trial.

Development, implementation and evaluation of an early warning system improvement programme for children in hospital: the PUMA mixed-methods study (2022)
Journal Article
Allen, D., Lloyd, A., Edwards, D., Grant, A., Hood, K., Huang, C., …Roland, D. (2022). Development, implementation and evaluation of an early warning system improvement programme for children in hospital: the PUMA mixed-methods study. Health and Social Care Delivery Research, 10(1), 307. https://doi.org/10.3310/CHCK4556

Objectives: (1) Identify, through systematic review, the following: evidence for core components of effective paediatric track-and-trigger tools and paediatric early warning systems, and contextual factors consequential for paediatric track-and-trigg... Read More about Development, implementation and evaluation of an early warning system improvement programme for children in hospital: the PUMA mixed-methods study.

Development, implementation and evaluation of an evidence-based paediatric early warning system improvement programme: the PUMA mixed methods study (2022)
Journal Article
Allen, D., Lloyd, A., Edwards, D., Hood, K., Huang, C., Hughes, J., …Roland, D. (2022). Development, implementation and evaluation of an evidence-based paediatric early warning system improvement programme: the PUMA mixed methods study. BMC health services research, 22(1), Article 9. https://doi.org/10.1186/s12913-021-07314-2

Background: Paediatric mortality rates in the United Kingdom are amongst the highest in Europe. Clinically missed deterioration is a contributory factor. Evidence to support any single intervention to address this problem is limited, but a cumulative... Read More about Development, implementation and evaluation of an evidence-based paediatric early warning system improvement programme: the PUMA mixed methods study.

Quantitative Scintigraphy Evaluated the Relationship between 131I Therapy and Salivary Glands Function in DTC Patients: A Retrospective Analysis (2022)
Journal Article
Lv, X., Yin, L., Wu, W., Li, N., Zhang, R., Li, X., Jia, Q., Tan, J., Wang, P., Zheng, X., He, X., Huang, C., Li, D., Wang, Y., & Meng, Z. (2022). Quantitative Scintigraphy Evaluated the Relationship between 131I Therapy and Salivary Glands Function in DTC Patients: A Retrospective Analysis. Journal of Healthcare Engineering, 2022, Article 7640405. https://doi.org/10.1155/2022/7640405

Purpose. Quantitative scintigraphy to evaluate salivary gland function changes in patients with differentiated thyroid cancer (DTC) after iodine-131 (131I) treatment. Methods. A total of 458 patients with DTC grouped by sex and age were included. Sal... Read More about Quantitative Scintigraphy Evaluated the Relationship between 131I Therapy and Salivary Glands Function in DTC Patients: A Retrospective Analysis.

Simplification or simulation: power calculation in clinical trials (2021)
Journal Article
Huang, C., Li, P., & Martin, C. R. (2022). Simplification or simulation: power calculation in clinical trials. Contemporary clinical trials, 113, Article 106663. https://doi.org/10.1016/j.cct.2021.106663

Background and objectives: A justifiable sample size is essential at trial design stage. Generally this task is completed by forming the main research question into a statistical procedure and then implementing the published formulae or software pack... Read More about Simplification or simulation: power calculation in clinical trials.