All Outputs (3)

Investigating the impact of α-synuclein and PD-L1 deletion on platelet function (2025)
Thesis
Sennett, C. (2025). Investigating the impact of α-synuclein and PD-L1 deletion on platelet function. (Thesis). University of Hull and University of York. https://hull-repository.worktribe.com/output/5182732

Platelet proteomic studies suggest that platelets express over 1,000 proteins, most of which have no known function in platelets. This thesis investigates two such proteins, α-synuclein and Programmed Death Ligand 1 (PD-L1), and their roles in essent... Read More about Investigating the impact of α-synuclein and PD-L1 deletion on platelet function.

α-Synuclein Deletion Impairs Platelet Function: A Role for SNARE Complex Assembly (2024)
Journal Article
Sennett, C., Jia, W., Khalil, J. S., Hindle, M. S., Coupland, C., Calaminus, S. D., Langer, J. D., Frost, S., Naseem, K. M., Rivero, F., Ninkina, N., Buchman, V., & Aburima, A. (2024). α-Synuclein Deletion Impairs Platelet Function: A Role for SNARE Complex Assembly. Cells, 13(24), Article 2089. https://doi.org/10.3390/cells13242089

Granule secretion is an essential platelet function that contributes not only to haemostasis but also to wound healing, inflammation, and atherosclerosis. Granule secretion from platelets is facilitated, at least in part, by Soluble N-ethylmaleimide-... Read More about α-Synuclein Deletion Impairs Platelet Function: A Role for SNARE Complex Assembly.

Investigating the effects of arginine methylation inhibitors on microdissected brain tumour biopsies maintained in a miniaturised perfusion system (2023)
Journal Article
Barry, A., Samuel, S. F., Hosni, I., Moursi, A., Feugere, L., Sennett, C. J., Deepak, S., Achawal, S., Rajaraman, C., Iles, A., Wollenberg Valero, K. C., Scott, I. S., Green, V., Stead, L. F., Greenman, J., Wade, M. A., & Beltran-Alvarez, P. (2023). Investigating the effects of arginine methylation inhibitors on microdissected brain tumour biopsies maintained in a miniaturised perfusion system. Lab on a chip, 23(11), 2664-2682. https://doi.org/10.1039/d3lc00204g

Arginine methylation is a post-translational modification that consists of the transfer of one or two methyl (CH3) groups to arginine residues in proteins. Several types of arginine methylation occur, namely monomethylation, symmetric dimethylation a... Read More about Investigating the effects of arginine methylation inhibitors on microdissected brain tumour biopsies maintained in a miniaturised perfusion system.