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All Outputs (8)

BREATHLEssness in INDIA (BREATHE-INDIA)–Study protocol for the co-design of a community breathlessness intervention in India using realist methods and intervention mapping (2023)
Journal Article
Clark, J., Salins, N., Pearson, M., Spathis, A., Currow, D. C., Williams, S., & Johnson, M. (2023). BREATHLEssness in INDIA (BREATHE-INDIA)–Study protocol for the co-design of a community breathlessness intervention in India using realist methods and intervention mapping. PLoS ONE, 18(11 November), Article e0293918. https://doi.org/10.1371/journal.pone.0293918

Background Breathlessness that persists despite treatment of causal disease(s) is disabling, associated with high therapy-related costs and poor socioeconomic outcomes. Low resource countries bear a disproportionate burden of respiratory problems, of... Read More about BREATHLEssness in INDIA (BREATHE-INDIA)–Study protocol for the co-design of a community breathlessness intervention in India using realist methods and intervention mapping.

Development of a Core Outcome Set for the research and assessment of malignant bowel obstruction (2023)
Journal Article
Bravington, A., Obita, G., Baddeley, E., Johnson, M., Murtagh, F., Currow, D., …Boland, J. (2023). Development of a Core Outcome Set for the research and assessment of malignant bowel obstruction. PLoS ONE, 18(8), Article e0289501. https://doi.org/10.1371/journal.pone.0289501

Background: Malignant bowel obstruction is experienced by 15% of people with advanced cancer, preventing them from eating and drinking and causing pain, nausea and vomiting. Surgery is not always appropriate. Management options include tube or stent... Read More about Development of a Core Outcome Set for the research and assessment of malignant bowel obstruction.

Modified-release morphine or placebo for chronic breathlessness: the MABEL trial protocol (2023)
Journal Article
Date, K., Williams, B., Cohen, J., Chaudhuri, N., Bajwah, S., Pearson, M., …Johnson, M. (2023). Modified-release morphine or placebo for chronic breathlessness: the MABEL trial protocol. ERJ Open Research, 9(4), Article 00167. https://doi.org/10.1183/23120541.00167-2023

Chronic breathlessness, a persistent and disabling symptom despite optimal treatment of underlying causes, is a frightening symptom with serious and widespread impact on patients and their carers. Clinical guidelines support the use of morphine for t... Read More about Modified-release morphine or placebo for chronic breathlessness: the MABEL trial protocol.

European Respiratory Society clinical practice guideline: palliative care for people with COPD or interstitial lung disease (2023)
Journal Article
Janssen, D. J., Bajwah, S., Boon, M. H., Coleman, C., Currow, D. C., Devillers, A., …Marsaa, K. (2023). European Respiratory Society clinical practice guideline: palliative care for people with COPD or interstitial lung disease. European respiratory journal, 62(2), https://doi.org/10.1183/13993003.02014-2022

There is increased awareness of palliative care needs in people with COPD or interstitial lung disease (ILD). This European Respiratory Society (ERS) task force aimed to provide recommendations for initiation and integration of palliative care into t... Read More about European Respiratory Society clinical practice guideline: palliative care for people with COPD or interstitial lung disease.

Phase II, double blind, placebo controlled, multi-site study to evaluate the safety, feasibility and desirability of conducting a phase III study of anamorelin for anorexia in people with small cell lung cancer: A study protocol (LUANA trial) (2023)
Journal Article
Sousa, M. S., Martin, P., Johnson, M. J., Lind, M., Maddocks, M., Bullock, A., …Currow, D. C. (2023). Phase II, double blind, placebo controlled, multi-site study to evaluate the safety, feasibility and desirability of conducting a phase III study of anamorelin for anorexia in people with small cell lung cancer: A study protocol (LUANA trial). PLoS ONE, 18(5 May), Article e0285850. https://doi.org/10.1371/journal.pone.0285850

Anorexia is experienced by most people with lung cancer during the course of their disease and treatment. Anorexia reduces response to chemotherapy and the ability of patients to cope with, and complete their treatment leading to greater morbidity, p... Read More about Phase II, double blind, placebo controlled, multi-site study to evaluate the safety, feasibility and desirability of conducting a phase III study of anamorelin for anorexia in people with small cell lung cancer: A study protocol (LUANA trial).

High-quality phase 3 studies do not support the use of somatostatin analogues to reduce vomiting in malignant bowel obstruction (2023)
Journal Article
Boland, J. W., Boland, E. G., & Currow, D. C. (2023). High-quality phase 3 studies do not support the use of somatostatin analogues to reduce vomiting in malignant bowel obstruction. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 31(4), Article 211. https://doi.org/10.1007/s00520-023-07669-8

Development of a Core Outcome Set for the research and assessment of inoperable malignant bowel obstruction (2023)
Journal Article
Bravington, A., Obita, G., Baddeley, E., Johnson, M. J., Murtagh, F. E., Currow, D. C., …Boland, J. W. (2023). Development of a Core Outcome Set for the research and assessment of inoperable malignant bowel obstruction. PLoS ONE, 18(8), Article e0289501. https://doi.org/10.1371/journal.pone.0289501

BACKGROUND: Malignant bowel obstruction is experienced by 15% of people with advanced cancer, preventing them from eating and drinking and causing pain, nausea and vomiting. Surgery is not always appropriate. Management options include tube or stent... Read More about Development of a Core Outcome Set for the research and assessment of inoperable malignant bowel obstruction.