Skip to main content

Research Repository

Advanced Search

Plant-expressed hepatitis B core antigen virus-like particles : characterization and investigation of their stability in simulated and pig gastro-intestinal fluids (2017)
Journal Article
Berardi, A., Lomonossoff, G. P., Evans, D. J., & Barker, S. A. (2017). Plant-expressed hepatitis B core antigen virus-like particles : characterization and investigation of their stability in simulated and pig gastro-intestinal fluids. International Journal of Pharmaceutics, 522(1-2), 147-156. doi:10.1016/j.ijpharm.2017.03.001

Virus-like particles (VLPs) are potential oral vaccine candidates, as their highly compact structure may allow them to withstand the harsh conditions of the gastro-intestinal (GI) environment. Hepatitis B core antigen (HBcAg) is an immunogenic protei... Read More about Plant-expressed hepatitis B core antigen virus-like particles : characterization and investigation of their stability in simulated and pig gastro-intestinal fluids.

Iron- and Cobalt-Catalyzed Synthesis of Carbene Phosphinidenes (2015)
Journal Article
Pal, K., Hemming, O. B., Day, B. M., Pugh, T., Evans, D. J., & Layfield, R. A. (2016). Iron- and Cobalt-Catalyzed Synthesis of Carbene Phosphinidenes. Angewandte Chemie, 55(5), 1690-1693. doi:10.1002/anie.201508303

© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. In the presence of stoichiometric or catalytic amounts of [M{N(SiMe 3 ) 2 } 2 ] (M=Fe, Co), N-heterocyclic carbenes (NHCs) react with primary phosphines to give a series of carbene phosphinidenes o... Read More about Iron- and Cobalt-Catalyzed Synthesis of Carbene Phosphinidenes.

Synthesis and characterisation of halide, separated ion pair, and hydride cyclopentadienyl iron bis(diphenylphosphino)ethane derivatives (2015)
Journal Article
Evans, D. J., Liddle, S. T., Patel, D., Blake, A. J., Cornish, A. D., Davies, E. S., …Wooles, A. (2015). Synthesis and characterisation of halide, separated ion pair, and hydride cyclopentadienyl iron bis(diphenylphosphino)ethane derivatives. Dalton transactions : an international journal of inorganic chemistry / RSoC, 44(31), 14159-14177 . https://doi.org/10.1039/c5dt00704f

Treatment of anhydrous FeX₂ (X = Cl, Br, I) with one equivalent of bis(diphenylphosphino)ethane (dppe) in refluxing THF afforded analytically pure white (X = Cl), light green (X = Br), and yellow (X = I) [FeX₂(dppe)]n (X = Cl, I; Br, II; I, III). Com... Read More about Synthesis and characterisation of halide, separated ion pair, and hydride cyclopentadienyl iron bis(diphenylphosphino)ethane derivatives.

Bionanomaterials from plant viruses (2015)
Book Chapter
Aljabali, A. A. A., & Evans, D. (2015). Bionanomaterials from plant viruses. In Y. Khudyakov, & P. Pumpens (Eds.), Viral Nanotechnology, 263-278. CRC Press. https://doi.org/10.1201/b18596-20

Plant virus capsids have emerged as useful biotemplates for material synthesis. All plant virus capsids are assembled with high-precision, three-dimensional structures providing nanoscale architectures that are highly monodisperse, can be produced in... Read More about Bionanomaterials from plant viruses.

Doping of inorganic materials in microreactors – preparation of Zn doped Fe₃O₄ nanoparticles (2015)
Journal Article
Simmons, M. D., Jones, N., Evans, D. J., Wiles, C., Watts, P., Salamon, S., …Francesconi, M. G. (2015). Doping of inorganic materials in microreactors – preparation of Zn doped Fe₃O₄ nanoparticles. Lab on a chip, 15(15), 3154-3162. https://doi.org/10.1039/c5lc00287g

Microreactor systems are now used more and more for the continuous production of metal nanoparticles and metal oxide nanoparticles owing to the controllability of the particle size, an important property in many applications. Here, for the first time... Read More about Doping of inorganic materials in microreactors – preparation of Zn doped Fe₃O₄ nanoparticles.

Structural insights into magnetic clusters grown inside virus capsids (2014)
Journal Article
Jaafar, M., Aljabali, A. A. A., Berlanga, I., Mas-Ballesté, R., Saxena, P., Warren, S., …de Pablo, P. J. (2014). Structural insights into magnetic clusters grown inside virus capsids. ACS applied materials & interfaces, 6(23), 20936-20942 . https://doi.org/10.1021/am505682x

Magnetic nanoparticles have multiple applications in materials science. In particular, virus capsids have been suggested as promising templates for building up nanometric-sized magnetic clusters by taking advantage of their inner cavity as a nanoreac... Read More about Structural insights into magnetic clusters grown inside virus capsids.

Templated mineralization by charge-modified cowpea mosaic virus (2013)
Book Chapter
Aljabali, A. A. A., & Evans, D. J. (2014). Templated mineralization by charge-modified cowpea mosaic virus. In Methods in Molecular Biology; Virus Hybrids as Nanomaterials, 89-95. Humana Press. doi:10.1007/978-1-62703-751-8_6

Templated mineralization of virus particles provides routes to narrowly dispersed nanoparticles that are not readily prepared by other means. The templated mineralization of metal or metal oxide on the external surface of wild-type cowpea mosaic viru... Read More about Templated mineralization by charge-modified cowpea mosaic virus.

CPMV-DOX delivers (2012)
Journal Article
Aljabali, A. A. A., Shukla, S., Lomonossoff, G. P., Steinmetz, N. F., & Evans, D. J. (2013). CPMV-DOX delivers. Molecular pharmaceutics, 10(1), 3-10. doi:10.1021/mp3002057

The plant virus, Cowpea mosaic virus (CPMV), is developed as a carrier of the chemotherapeutic drug doxorubicin (DOX). CPMV-DOX conjugate, in which eighty DOX molecules are covalently bound to external surface carboxylates of the viral nanoparticle (... Read More about CPMV-DOX delivers.

Liquid viruses by nanoscale engineering of capsid surfaces (2012)
Journal Article
Patil, A. J., McGrath, N., Elaine Barclay, J., Evans, D. J., Cölfen, H., Manners, I., …Mann, S. (2012). Liquid viruses by nanoscale engineering of capsid surfaces. Advanced materials, 24(33), 4557-4563. doi:10.1002/adma.201201032

Surface engineering of plant virus capsids via cationization and stoichiometric coupling of a polymer surfactant coronal layer produces a highly concentrated, solvent-free liquid virus at 28 °C. These ionic bionanoconstructs are viscoelastic, retain... Read More about Liquid viruses by nanoscale engineering of capsid surfaces.

Charge modified cowpea mosaic virus particles for templated mineralization (2011)
Journal Article
Aljabali, A. A. A., Barclay, J. E., Cespedes, O., Rashid, A., Staniland, S. S., Lomonossoff, G. P., & Evans, D. J. (2011). Charge modified cowpea mosaic virus particles for templated mineralization. Advanced Functional Materials, 21(21), 4137-4142. doi:10.1002/adfm.201101048

Surface charge modification of wild-type Cowpea mosaic virus, a plant virus, is sufficient to promote the templated mineralization of metal and metal oxide. Surface negative charge is increased by the chemical introduction of succinamate on surface l... Read More about Charge modified cowpea mosaic virus particles for templated mineralization.

Virus-templated silica nanoparticles (2009)
Journal Article
Steinmetz, N. F., Shah, S. N., Barclay, J. E., Rallapalli, G., Lomonossoff, G. P., & Evans, D. J. (2009). Virus-templated silica nanoparticles. Small, 5(7), 813-816. doi:10.1002/smll.200801348

An engineered variant of the plant virus, Cowpea mosaic virus, can template the controlled fabrication of silica nanoparticles of ≈30 nm diameter under environmentally benign conditions at ambient temperature and in aqueous solvent. This is the first... Read More about Virus-templated silica nanoparticles.