All Outputs (4)

Multicellular model of neuroblastoma proposes unconventional therapy based on multiple roles of p53 (2024)
Journal Article
Wertheim, K. Y., Chisholm, R., Richmond, P., & Walker, D. (2024). Multicellular model of neuroblastoma proposes unconventional therapy based on multiple roles of p53. PLoS Computational Biology, 20(12), Article e1012648. https://doi.org/10.1371/journal.pcbi.1012648

Neuroblastoma is the most common extra-cranial solid tumour in children. Over half of all high-risk cases are expected to succumb to the disease even after chemotherapy, surgery, and immunotherapy. Although the importance of MYCN amplification in thi... Read More about Multicellular model of neuroblastoma proposes unconventional therapy based on multiple roles of p53.

Mathematical Model of Clonal Evolution Proposes a Personalised Multi-Modal Therapy for High-Risk Neuroblastoma (2023)
Journal Article
Italia, M., Wertheim, K. Y., Taschner-Mandl, S., Walker, D., & Dercole, F. (2023). Mathematical Model of Clonal Evolution Proposes a Personalised Multi-Modal Therapy for High-Risk Neuroblastoma. Cancers, 15(7), Article 1986. https://doi.org/10.3390/cancers15071986

Neuroblastoma is the most common extra-cranial solid tumour in children. Despite multi-modal therapy, over half of the high-risk patients will succumb. One contributing factor is the one-size-fits-all nature of multi-modal therapy. For example, durin... Read More about Mathematical Model of Clonal Evolution Proposes a Personalised Multi-Modal Therapy for High-Risk Neuroblastoma.

A theoretical analysis of the scale separation in a model to predict solid tumour growth (2022)
Journal Article
de Melo Quintela, B., Hervas-Raluy, S., Garcia-Aznar, J. M., Walker, D., Wertheim, K. Y., & Viceconti, M. (2022). A theoretical analysis of the scale separation in a model to predict solid tumour growth. Journal of Theoretical Biology, 547, Article 111173. https://doi.org/10.1016/j.jtbi.2022.111173

Solid tumour growth depends on a host of factors which affect the cell life cycle and extracellular matrix vascularization that leads to a favourable environment. The whole solid tumour can either grow or wither in response to the action of the immun... Read More about A theoretical analysis of the scale separation in a model to predict solid tumour growth.

PRIMAGE project: predictive in silico multiscale analytics to support childhood cancer personalised evaluation empowered by imaging biomarkers (2020)
Journal Article
Martí-Bonmatí, L., Alberich-Bayarri, Á., Ladenstein, R., Blanquer, I., Segrelles, J. D., Cerdá-Alberich, L., Gkontra, P., Hero, B., García-Aznar, J. M., Keim, D., Jentner, W., Seymour, K., Jiménez-Pastor, A., González-Valverde, I., Martínez de las Heras, B., Essiaf, S., Walker, D., Rochette, M., Bubak, M., Mestres, J., …Neri, E. (2020). PRIMAGE project: predictive in silico multiscale analytics to support childhood cancer personalised evaluation empowered by imaging biomarkers. European Radiology Experimental, 4(1), https://doi.org/10.1186/s41747-020-00150-9

PRIMAGE is one of the largest and more ambitious research projects dealing with medical imaging, artificial intelligence and cancer treatment in children. It is a 4-year European Commission-financed project that has 16 European partners in the consor... Read More about PRIMAGE project: predictive in silico multiscale analytics to support childhood cancer personalised evaluation empowered by imaging biomarkers.