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All Outputs (385)

Risk factors for incident dementia in England and Wales: The Medical Research Council Cognitive Function and Ageing Study. A population-based nested case-control study (2006)
Journal Article
Yip, A. G., Brayne, C., & Matthews, F. E. (2006). Risk factors for incident dementia in England and Wales: The Medical Research Council Cognitive Function and Ageing Study. A population-based nested case-control study. Age and ageing, 35(2), 154-160. https://doi.org/10.1093/ageing/afj030

Objective: To investigate a number of prospectively collected factors (sociodemographic, medical and behavioural) and their association with incident dementia in a population-based cohort. Design: Nested case-control analysis (at 2 and 6 years) of a... Read More about Risk factors for incident dementia in England and Wales: The Medical Research Council Cognitive Function and Ageing Study. A population-based nested case-control study.

Prevalence and causes of blindness and low vision in southern Sudan (2006)
Journal Article
Ngondi, J., Ole-Sempele, F., Onsarigo, A., Matende, I., Baba, S., Reacher, M., Matthews, F., Brayne, C., & Emerson, P. M. (2006). Prevalence and causes of blindness and low vision in southern Sudan. PLoS Medicine, 3(12), 2416-2423. https://doi.org/10.1371/journal.pmed.0030477

Background: Blindness and low vision are thought to be common in southern Sudan. However, the magnitude and geographical distribution are largely unknown. We aimed to estimate the prevalence of blindness and low vision, identify the main causes of bl... Read More about Prevalence and causes of blindness and low vision in southern Sudan.

Depression in the elderly: Pathological study of raphe and locus ceruleus (2005)
Journal Article
Syed, A., Chatfield, M., Matthews, F., Harrison, P., Brayne, C., & Esiri, M. M. (2005). Depression in the elderly: Pathological study of raphe and locus ceruleus. Neuropathology and Applied Neurobiology, 31(4), 405-413. https://doi.org/10.1111/j.1365-2990.2005.00662.x

Depressive symptoms in the elderly are common and disabling and constitute a risk factor for the development of Alzheimer's disease (AD). One hypothesis worth exploring is that depression in the elderly is related to development of AD pathology at su... Read More about Depression in the elderly: Pathological study of raphe and locus ceruleus.

Brief cognitive assessment in a UK population sample - Distributional properties and the relationship between the MMSE and an extended mental state examination (2005)
Journal Article
Huppert, F. A., Cabelli, S. T., & Matthews, F. E. (2005). Brief cognitive assessment in a UK population sample - Distributional properties and the relationship between the MMSE and an extended mental state examination. BMC Geriatrics, 5, https://doi.org/10.1186/1471-2318-5-7

Background: Despite the MMSE's known flaws, it is still used extensively as both a screening instrument for dementia and a population measure of cognitive ability. The aim of this paper is to provide data on the distribution of MMSE scores in a repre... Read More about Brief cognitive assessment in a UK population sample - Distributional properties and the relationship between the MMSE and an extended mental state examination.

Brain donation for research: consent and re-consent post Alder Hey. (2005)
Journal Article
Barnes, L., Matthews, F. E., Barber, B., Davies, L., Lloyd, D., Brayne, C., & Parry, B. (2005). Brain donation for research: consent and re-consent post Alder Hey

Background: Recent scandals relating to the unconsented retention and use of human organs in the UK have led to widespread changes to governance and ethical frameworks for research throughout England and Wales. Ethics committees now ask for proof of... Read More about Brain donation for research: consent and re-consent post Alder Hey..

The incidence of dementia in England and Wales: Findings from the five identical sites of the MRC CFA study (2005)
Journal Article
Matthews, F., Brayne, C., Arie, T., Bond, J., Copeland, J., Day, N., Devakumar, D., Dewey, M., Fairbairn, A., Grimley-Evans, J., Huppert, F., Kay, D., McCracken, C., McKeith, I., Morgan, K., Paykel, G., Barnes, L., Chatfield, M., Esiri, M., Forster, G., …Parker, C. (2005). The incidence of dementia in England and Wales: Findings from the five identical sites of the MRC CFA study. PLoS Medicine, 2(8), 0753-0763. https://doi.org/10.1371/journal.pmed.0020193

Background: Although incidence of dementia is known to vary between nations, variation within country has not been explored because most incidence studies are single site or have insufficient numbers to compare sites. Few countries have conducted mul... Read More about The incidence of dementia in England and Wales: Findings from the five identical sites of the MRC CFA study.

Challenges in the epidemiological investigation of the relationships between physical activity, obesity, diabetes, dementia and depression (2005)
Presentation / Conference Contribution
Brayne, C., Gao, L., & Matthews, F. Challenges in the epidemiological investigation of the relationships between physical activity, obesity, diabetes, dementia and depression

There are many challenges facing epidemiologists wishing to investigate relationships between physical activity, obesity, diabetes, dementia and depression, all of which are complex fields in their own right. There is a large literature investigating... Read More about Challenges in the epidemiological investigation of the relationships between physical activity, obesity, diabetes, dementia and depression.

Diseases and impairments as risk factors for onset of disability in the older population in England and Wales: Findings from the medical research council cognitive function and ageing study (2005)
Journal Article
Spiers, N. A., Matthews, R. J., Jagger, C., Matthews, F. E., Boult, C., Robinson, T. G., & Brayne, C. (2005). Diseases and impairments as risk factors for onset of disability in the older population in England and Wales: Findings from the medical research council cognitive function and ageing study. The journals of gerontology. Series A, Biological sciences and medical sciences, 60(2), 248-254. https://doi.org/10.1093/gerona/60.2.248

Background. This paper reports the association between self-reported diseases and impairments and 2-year onset of disability in a prospective study of people aged 65 years or older in five urban and rural centers in England and Wales (Medical Researc... Read More about Diseases and impairments as risk factors for onset of disability in the older population in England and Wales: Findings from the medical research council cognitive function and ageing study.

A systematic literature review of attrition between waves in longitudinal studies in the elderly shows a consistent pattern of dropout between differing studies (2005)
Journal Article
Chatfield, M. D., Brayne, C. E., & Matthews, F. E. (2005). A systematic literature review of attrition between waves in longitudinal studies in the elderly shows a consistent pattern of dropout between differing studies. Journal of clinical epidemiology, 58(1), 13-19. https://doi.org/10.1016/j.jclinepi.2004.05.006

Longitudinal studies of the elderly are complicated by the loss of individuals between waves due to death or other dropout mechanisms. Factors that affect dropout may well be similar from one study to another. This article systematically reviews all... Read More about A systematic literature review of attrition between waves in longitudinal studies in the elderly shows a consistent pattern of dropout between differing studies.

Comparison of the pathology of cerebral white matter with post-mortem magnetic resonance imaging (MRI) in the elderly brain (2004)
Journal Article
Fernando, M. S., O'Brien, J. T., Perry, R. H., English, P., Forster, G., McMeekin, W., Slade, J. Y., Golkhar, A., Matthews, F. E., Barber, R., Kalaria, R. N., & Ince, P. G. (2004). Comparison of the pathology of cerebral white matter with post-mortem magnetic resonance imaging (MRI) in the elderly brain. Neuropathology and Applied Neurobiology, 30(4), 385-395. https://doi.org/10.1111/j.1365-2990.2004.00550.x

White matter lesions (WML) on magnetic resonance imaging (MRI) brain scans are associated with ageing. They are unrelated to specific disorders, and their impact on cognitive and other brain functions is poorly characterized. Pathological studies oft... Read More about Comparison of the pathology of cerebral white matter with post-mortem magnetic resonance imaging (MRI) in the elderly brain.

The cervical cancer epidemic that screening has prevented in the UK (2004)
Journal Article
Peto, P. J., Gilham, P. C., Fletcher, O., & Matthews, F. E. (2004). The cervical cancer epidemic that screening has prevented in the UK. Lancet, 364(9430), 249-256. https://doi.org/10.1016/S0140-6736%2804%2916674-9

Background Recent reports suggest that the reduction in mortality achieved by the UK national cervical screening programme is too small to justify its financial and psychosocial costs, except perhaps in a few high-risk women. Methods We analysed tren... Read More about The cervical cancer epidemic that screening has prevented in the UK.

Attrition and bias in the MRC cognitive function and ageing study: An epidemiological investigation (2004)
Journal Article
Matthews, F. E., Chatfield, M., Freeman, C., McCracken, C., & Brayne, C. (2004). Attrition and bias in the MRC cognitive function and ageing study: An epidemiological investigation. BMC public health, 4, 1-27. https://doi.org/10.1186/1471-2458-4-12

Background: Any hypothesis in longitudinal studies may be affected by attrition and poor response rates. The MRC Cognitive Function and Ageing study (MRC CFAS) is a population based longitudinal study in five centres with identical methodology in Eng... Read More about Attrition and bias in the MRC cognitive function and ageing study: An epidemiological investigation.

Performance and normative values of a concise neuropsychological test (CAMCOG) in an elderly population sample (2003)
Journal Article
Williams, J. G., Huppert, F. A., Matthews, F. E., & Nickson, J. (2003). Performance and normative values of a concise neuropsychological test (CAMCOG) in an elderly population sample. International journal of geriatric psychiatry, 18(7), 631-644. https://doi.org/10.1002/gps.886

Background: CAMCOG is a widely used brief neuropsychological test. To date no normative values are available for English speaking individuals representative of the general population. Objectives: The aims of the study were to describe the population... Read More about Performance and normative values of a concise neuropsychological test (CAMCOG) in an elderly population sample.

Gender Differences in Life Expectancy Free of Impairment at Older Ages (2002)
Journal Article
Jagger, C., & Matthews, F. (2002). Gender Differences in Life Expectancy Free of Impairment at Older Ages. Journal of Women and Aging, 14(1-2), 85-97. https://doi.org/10.1300/J074v14n01_06

This article uses data from the United Kingdom Medical Research Council Cognitive Function and Ageing study (MRC CFAS) to analyze morbidity associated with three areas of impairment. We use cognitive status, functional status, and physical illness to... Read More about Gender Differences in Life Expectancy Free of Impairment at Older Ages.

Prevalence of dementia in institutional care (2002)
Journal Article
Matthews, F. E., & Dening, T. (2002). Prevalence of dementia in institutional care. Lancet, 360(9328), 225-226. https://doi.org/10.1016/S0140-6736%2802%2909461-8

Information about dementia prevalence in residential and nursing care homes helps these institutions to meet residents' needs. We combined residential characteristics ascertained at a screening interview in 1991-93 with dementia diagnoses from assess... Read More about Prevalence of dementia in institutional care.

Pathological correlates of dementia [3] (multiple letters) (2002)
Journal Article
Kay, D. W., Roth, M., Ince, P. G., Matthews, F., & Bayne, C. (2002). Pathological correlates of dementia [3] (multiple letters). Lancet, 359(9306), 624-625. https://doi.org/10.1016/S0140-6736%2802%2907724-3

The Pulsair 3000 tonometer - How many readings need to be taken to ensure accuracy of the average? (2001)
Journal Article
McCaghrey, G. E., & Matthews, F. E. (2001). The Pulsair 3000 tonometer - How many readings need to be taken to ensure accuracy of the average?. Ophthalmic and Physiological Optics, 21(4), 334-338. https://doi.org/10.1016/S0275-5408%2800%2900040-5

Manufacturers of non-contact tonometers recommend that a number of readings are taken on each eye, and an average obtained. With the Keeler Pulsair 3000 it is advised to take four readings, and average these. This report analyses readings in 100 subj... Read More about The Pulsair 3000 tonometer - How many readings need to be taken to ensure accuracy of the average?.

Health and ill-health in the older population in England and Wales (2001)
Journal Article
Brayne, C., Matthews, F. E., McGee, M. A., & Jagger, C. (2001). Health and ill-health in the older population in England and Wales. Age and ageing, 30(1), 53-62. https://doi.org/10.1093/ageing/30.1.53

Objective: to provide a profile of disorders and disabilities in the older population. Design: the MRC CFAS drew population samples of people aged 64 years and over from Family Health Service Authority lists at five sites and asked participants about... Read More about Health and ill-health in the older population in England and Wales.

Cancer mortality in relatives of women with breast cancer: The OPCS study (1996)
Journal Article
Peto, J., Easton, D. F., Matthews, F. E., Ford, D., & Swerdlow, A. J. (1996). Cancer mortality in relatives of women with breast cancer: The OPCS study. International journal of cancer. Journal international du cancer, 65(3), 275-283. https://doi.org/10.1002/%28SICI%291097-0215%2819960126%2965%3A3%3C275%3A%3AAID-IJC1%3E3.0.CO%3B2-X

Mortality from cancer and other causes in male and female first-degree relatives of women with breast cancer diagnosed before age 60 has been examined in a large population-based cohort study, providing estimates of familial risks free from ascertain... Read More about Cancer mortality in relatives of women with breast cancer: The OPCS study.