All Outputs (21)

Alterations in the blood brain barrier in ageing cerebral cortex in relationship to Alzheimer-type pathology: A study in the MRC-CFAS population neuropathology cohort (2011)
Journal Article
Viggars, A. P., Wharton, S. B., Simpson, J. E., Matthews, F. E., Brayne, C., Savva, G. M., …Ince, P. G. (2011). Alterations in the blood brain barrier in ageing cerebral cortex in relationship to Alzheimer-type pathology: A study in the MRC-CFAS population neuropathology cohort. Neuroscience letters, 505(1), 25-30. https://doi.org/10.1016/j.neulet.2011.09.049

Impairment of the blood brain barrier (BBB) in human brain ageing and its relationship to Alzheimer-type pathology remains poorly defined. We have investigated the BBB in temporal cortex of brain donations from a population-representative sample of 9... Read More about Alterations in the blood brain barrier in ageing cerebral cortex in relationship to Alzheimer-type pathology: A study in the MRC-CFAS population neuropathology cohort.

Microarray analysis of the astrocyte transcriptome in the aging brain: Relationship to Alzheimer's pathology and APOE genotype (2011)
Journal Article
Simpson, J. E., Ince, P. G., Shaw, P. J., Heath, P. R., Raman, R., Garwood, C. J., …Wharton, S. B. (2011). Microarray analysis of the astrocyte transcriptome in the aging brain: Relationship to Alzheimer's pathology and APOE genotype. Neurobiology of Aging, 32(10), 1795-1807. https://doi.org/10.1016/j.neurobiolaging.2011.04.013

Astrocytes contribute to a variety of functions in the brain, including homeostasis, synapse formation, plasticity, and metabolism. Astrocyte dysfunction may disrupt their normal role, including neuronal support, thereby contributing to neurodegenera... Read More about Microarray analysis of the astrocyte transcriptome in the aging brain: Relationship to Alzheimer's pathology and APOE genotype.

The reliability of assigning individuals to cognitive states using the Mini Mental-State Examination: A population-based prospective cohort study (2011)
Journal Article
Marioni, R. E., Chatfield, M., Brayne, C., & Matthews, F. E. (2011). The reliability of assigning individuals to cognitive states using the Mini Mental-State Examination: A population-based prospective cohort study. BMC Medical Research Methodology, 11, https://doi.org/10.1186/1471-2288-11-127

Background: Previous investigations of test re-test reliability of the Mini-Mental State Examination (MMSE) have used correlations and statistics such as Cronbach's to assess consistency. In practice, the MMSE is usually used to group individuals int... Read More about The reliability of assigning individuals to cognitive states using the Mini Mental-State Examination: A population-based prospective cohort study.

Full-scale scores of the Mini Mental State Examination can be generated from an abbreviated version (2011)
Journal Article
Matthews, F. E., Stephan, B. C., Khaw, K. T., Hayat, S., Luben, R., Bhaniani, A., …Brayne, C. (2011). Full-scale scores of the Mini Mental State Examination can be generated from an abbreviated version. Journal of clinical epidemiology, 64(9), 1005-1013. https://doi.org/10.1016/j.jclinepi.2010.11.014

Objective: To determine whether the full Mini Mental State Examination (MMSE) scale range can be derived from an abbreviated 11-item version that was designed for testing general cognitive function in a cohort where only a small proportion were expec... Read More about Full-scale scores of the Mini Mental State Examination can be generated from an abbreviated version.

Anticholinergic medication use and cognitive impairment in the older population: The medical research council cognitive function and ageing study (2011)
Journal Article
Fox, C., Richardson, K., Maidment, I. D., Savva, G. M., Matthews, F. E., Smithard, D., …Brayne, C. (2011). Anticholinergic medication use and cognitive impairment in the older population: The medical research council cognitive function and ageing study. Journal of the American Geriatrics Society, 59(8), 1477-1483. https://doi.org/10.1111/j.1532-5415.2011.03491.x

Objectives: To determine whether the use of medications with possible and definite anticholinergic activity increases the risk of cognitive impairment and mortality in older people and whether risk is cumulative. Design: A 2-year longitudinal study o... Read More about Anticholinergic medication use and cognitive impairment in the older population: The medical research council cognitive function and ageing study.

Variation over time in the association between polypharmacy and mortality in the older population (2011)
Journal Article
Richardson, K., Ananou, A., Lafortune, L., Brayne, C., & Matthews, F. E. (2011). Variation over time in the association between polypharmacy and mortality in the older population. Drugs and Aging, 28(7), 547-560. https://doi.org/10.2165/11592000-000000000-00000

Background: In the older population, multimorbidity is common and best practice may invite the prescription of multiple medications. Objective: To examine the association between polypharmacy, defined as the concurrent use of five or more prescriptio... Read More about Variation over time in the association between polypharmacy and mortality in the older population.

Occurrence of medical co-morbidity in mild cognitive impairment: Implications for generalisation of MCI research (2011)
Journal Article
Stephan, B. C., Brayne, C., Savva, G. M., & Matthews, F. E. (2011). Occurrence of medical co-morbidity in mild cognitive impairment: Implications for generalisation of MCI research. Age and ageing, 40(4), 501-507. https://doi.org/10.1093/ageing/afr057

Background: diagnosis of mild cognitive impairment (MCI) typically excludes individuals with medical co-morbidity. Interest in MCI screening raises the questions of what are the best criteria to identify a representative sample and what factors are a... Read More about Occurrence of medical co-morbidity in mild cognitive impairment: Implications for generalisation of MCI research.

Life course trajectories of systolic blood pressure using longitudinal data from eight UK cohorts (2011)
Journal Article
Wills, A. K., Lawlor, D. A., Matthews, F. E., Sayer, A. A., Bakra, E., Ben-Shlomo, Y., …Hardy, R. (2011). Life course trajectories of systolic blood pressure using longitudinal data from eight UK cohorts. PLoS Medicine, 8(6), https://doi.org/10.1371/journal.pmed.1000440

Background: Much of our understanding of the age-related progression of systolic blood pressure (SBP) comes from cross-sectional data, which do not directly capture within-individual change. We estimated life course trajectories of SBP using longitud... Read More about Life course trajectories of systolic blood pressure using longitudinal data from eight UK cohorts.

Are terminal decline and its potential indicators detectable in population studies of the oldest old? (2011)
Journal Article
Muniz-Terrera, G., Matthews, F. E., Stephan, B., & Brayne, C. (2011). Are terminal decline and its potential indicators detectable in population studies of the oldest old?. International journal of geriatric psychiatry, 26(6), 584-592. https://doi.org/10.1002/gps.2566

Objectives To explore whether it is possible to detect decline in global scores of cognitive function in the proximity of death whilst simultaneously investigating potential risk profiles. Methods Using the Mini Mental State Examination in a populati... Read More about Are terminal decline and its potential indicators detectable in population studies of the oldest old?.

Cognitive lifestyle and long-term risk of dementia and survival after diagnosis in a multicenter population-based cohort (2011)
Journal Article
Valenzuela, M., Brayne, C., Sachdev, P., Wilcock, G., & Matthews, F. (2011). Cognitive lifestyle and long-term risk of dementia and survival after diagnosis in a multicenter population-based cohort. American Journal of Epidemiology, 173(9), 1004-1012. https://doi.org/10.1093/aje/kwq476

An active cognitive lifestyle has been linked to dementia incidence and survival, but the separate and combined effects of its subcomponents are not clear. Data were derived from the Medical Research Council Cognitive Function and Ageing Study, a pop... Read More about Cognitive lifestyle and long-term risk of dementia and survival after diagnosis in a multicenter population-based cohort.

Association between APOE genotype, neuropathology and dementia in the older population of England and Wales (2011)
Journal Article
Nicoll, J. A., Savva, G. M., Stewart, J., Matthews, F. E., Brayne, C., & Ince, P. (2011). Association between APOE genotype, neuropathology and dementia in the older population of England and Wales. Neuropathology and Applied Neurobiology, 37(3), 285-294. https://doi.org/10.1111/j.1365-2990.2010.01130.x

Aims: Apolipoprotein E (APOE) genotype is the major genetic risk factor for sporadic Alzheimer's disease (AD) but it is unclear how this is mediated. Most studies of APOE genotype have used case-control design to compare groups differing by two varia... Read More about Association between APOE genotype, neuropathology and dementia in the older population of England and Wales.

Random change point models: Investigating cognitive decline in the presence of missing data (2011)
Journal Article
Terrera, G. M., van den Hout, A., & Matthews, F. E. (2011). Random change point models: Investigating cognitive decline in the presence of missing data. Journal of Applied Statistics, 38(4), 705-716. https://doi.org/10.1080/02664760903563668

With the aim of identifying the age of onset of change in the rate of cognitive decline while accounting for the missing observations, we considered a selection modelling framework. A random change point model was fitted to data from a population-bas... Read More about Random change point models: Investigating cognitive decline in the presence of missing data.

Smooth random change point models (2011)
Journal Article
Van Den Hout, A., Muniz-Terrera, G., & Matthews, F. E. (2011). Smooth random change point models. Statistics in Medicine, 30(6), 599-610. https://doi.org/10.1002/sim.4127

Change point models are used to describe processes over time that show a change in direction. An example of such a process is cognitive ability, where a decline a few years before death is sometimes observed. A broken-stick model consists of two line... Read More about Smooth random change point models.

The association between late-life cognitive test scores and retrospective informant interview data (2011)
Journal Article
Marioni, R. E., Matthews, F. E., & Brayne, C. (2011). The association between late-life cognitive test scores and retrospective informant interview data. International Psychogeriatrics, 23(2), 274-279. https://doi.org/10.1017/S1041610210001201

Background: Cognitive assessment of older persons, particularly those with impairment, is hampered by measurement error and the ethical issues of testing people with dementia. A potential source of valuable information about end-of-life cognitive sta... Read More about The association between late-life cognitive test scores and retrospective informant interview data.

Nonlinear decline of mini-mental state examination in Parkinson's disease (2011)
Journal Article
Aarsland, D., Muniz, G., & Matthews, F. (2011). Nonlinear decline of mini-mental state examination in Parkinson's disease. Movement Disorders, 26(2), 334-337. https://doi.org/10.1002/mds.23416

The trajectory of cognitive functioning in patients with Parkinson's disease (PD) is not known. We used a random change point model to study the individual cognitive trajectory for up to 15 years in a prevalence sample of 238 PD patients, and used th... Read More about Nonlinear decline of mini-mental state examination in Parkinson's disease.

Neuropathological correlates of late-life depression in older people (2011)
Journal Article
Tsopelas, C., Stewart, R., Savva, G. M., Brayne, C., Ince, P., Thomas, A., & Matthews, F. E. (2011). Neuropathological correlates of late-life depression in older people. British Journal of Psychiatry, 198(2), 109-114. https://doi.org/10.1192/bjp.bp.110.078816

Background: Depression is common in old age and is associated with risk of dementia, but its neuropathological correlates in the community are unknown. Aims: To investigate for the first time in a population-representative sample of people with no de... Read More about Neuropathological correlates of late-life depression in older people.

Joint modeling of longitudinal change and survival (2011)
Journal Article
Terrera, G. M., Piccinin, A. M., Johansson, B., Matthews, F., & Hofer, S. M. (2011). Joint modeling of longitudinal change and survival. GeroPsych: The Journal of Gerontopsychology and Geriatric Psychiatry, 24(4), 177-185. https://doi.org/10.1024/1662-9647/a000047

Joint longitudinal-survival models are useful when repeated measures and event time data are available and possibly associated. The application of this joint model in aging research is relatively rare, albeit particularly useful, when there is the po... Read More about Joint modeling of longitudinal change and survival.

Terminal decline from within- and between-person perspectives, accounting for incident dementia (2011)
Journal Article
Piccinin, A. M., Muniz, G., Matthews, F. E., & Johansson, B. (2011). Terminal decline from within- and between-person perspectives, accounting for incident dementia. The Journals of Gerontology, Series B: Psychological Sciences and Social Sciences, 66 B(4), 391-401. https://doi.org/10.1093/geronb/gbr010

Objective. The terminal cognitive decline hypothesis has been debated for almost 50 years. This hypothesis implies a change in rate of decline within an individual. Therefore, we examine the hypothesis from a within-person perspective using a time to... Read More about Terminal decline from within- and between-person perspectives, accounting for incident dementia.

Epidemiological neuropathology: The MRC cognitive function and aging study experience (2011)
Journal Article
Wharton, S. B., Brayne, C., Savva, G. M., Matthews, F. E., Forster, G., Simpson, J., …Ince, P. G. (2011). Epidemiological neuropathology: The MRC cognitive function and aging study experience. Journal of Alzheimer's Disease, 25(2), 359-372. https://doi.org/10.3233/JAD-2011-091402

We here describe the study-design major findings from the neuropathological component of the Medical Research Council Cognitive Function and Aging Study (MRC CFAS). MRC CFAS is a population-representative study of aging and health including more than... Read More about Epidemiological neuropathology: The MRC cognitive function and aging study experience.

A European perspective on population studies of dementia (2011)
Journal Article
Brayne, C., Stephan, B. C., & Matthews, F. E. (2011). A European perspective on population studies of dementia. Alzheimer's & dementia, 7(1), 3-9. https://doi.org/10.1016/j.jalz.2010.12.003

The change in the world's age demographics and the predicted rise in the incidence of age-related diseases, including dementia, is a source of major public health concern. Major research effort in both the United States and Europe has been targeted t... Read More about A European perspective on population studies of dementia.