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Neuropathological correlates of late-life depression in older people

Tsopelas, Christos; Stewart, Robert; Savva, George M.; Brayne, Carol; Ince, Paul; Thomas, Alan; Matthews, Fiona E.

Authors

Christos Tsopelas

Robert Stewart

George M. Savva

Carol Brayne

Paul Ince

Alan Thomas



Abstract

Background: Depression is common in old age and is associated with risk of dementia, but its neuropathological correlates in the community are unknown. Aims: To investigate for the first time in a population-representative sample of people with no dementia the association between depression observed during life and neurofibrillary tangles, diffuse and neuritic plaques, Lewy bodies, brain atrophy and cerebrovascular disease found in the brain at post-mortem. Method: Out of 456 donations to a population-based study, 153 brains were selected where donors had no dementia measured in life. Alzheimer and vascular pathology measures, Lewy bodies and neuronal loss were compared between those with (n = 36) and without (n = 117) depression ascertained using a fully structured diagnostic interview during life. Brain areas examined included frontal, parietal, temporal and occipital cortical areas as well as the entorhinal cortex, hippocampus and brain-stem monoaminergic nuclei. Results: Depression was significantly associated with the presence of subcortical Lewy bodies. No association was found between depression and cerebrovascular or Alzheimer pathology in cortical or subcortical areas, although depression was associated with neuronal loss in the hippocampus as well as in some of the subcortical structures investigated (nucleus basalis, substantia nigra, raphe nucleus). Conclusions: Late-life depression was associated with subcortical and hippocampal neuronal loss but not with cerebrovascular or Alzheimer pathology.

Citation

Tsopelas, C., Stewart, R., Savva, G. M., Brayne, C., Ince, P., Thomas, A., & Matthews, F. E. (2011). Neuropathological correlates of late-life depression in older people. British Journal of Psychiatry, 198(2), 109-114. https://doi.org/10.1192/bjp.bp.110.078816

Journal Article Type Article
Publication Date Feb 1, 2011
Deposit Date Dec 8, 2023
Journal British Journal of Psychiatry
Print ISSN 0007-1250
Electronic ISSN 1472-1465
Publisher Royal College of Psychiatrists
Volume 198
Issue 2
Pages 109-114
DOI https://doi.org/10.1192/bjp.bp.110.078816
Public URL https://hull-repository.worktribe.com/output/4454931