Christos Tsopelas
Neuropathological correlates of late-life depression in older people
Tsopelas, Christos; Stewart, Robert; Savva, George M.; Brayne, Carol; Ince, Paul; Thomas, Alan; Matthews, Fiona E.
Authors
Robert Stewart
George M. Savva
Carol Brayne
Paul Ince
Alan Thomas
Professor Fiona Matthews F.Matthews@hull.ac.uk
Pro-Vice-Chancellor Research and Enterprise
Abstract
Background: Depression is common in old age and is associated with risk of dementia, but its neuropathological correlates in the community are unknown. Aims: To investigate for the first time in a population-representative sample of people with no dementia the association between depression observed during life and neurofibrillary tangles, diffuse and neuritic plaques, Lewy bodies, brain atrophy and cerebrovascular disease found in the brain at post-mortem. Method: Out of 456 donations to a population-based study, 153 brains were selected where donors had no dementia measured in life. Alzheimer and vascular pathology measures, Lewy bodies and neuronal loss were compared between those with (n = 36) and without (n = 117) depression ascertained using a fully structured diagnostic interview during life. Brain areas examined included frontal, parietal, temporal and occipital cortical areas as well as the entorhinal cortex, hippocampus and brain-stem monoaminergic nuclei. Results: Depression was significantly associated with the presence of subcortical Lewy bodies. No association was found between depression and cerebrovascular or Alzheimer pathology in cortical or subcortical areas, although depression was associated with neuronal loss in the hippocampus as well as in some of the subcortical structures investigated (nucleus basalis, substantia nigra, raphe nucleus). Conclusions: Late-life depression was associated with subcortical and hippocampal neuronal loss but not with cerebrovascular or Alzheimer pathology.
Citation
Tsopelas, C., Stewart, R., Savva, G. M., Brayne, C., Ince, P., Thomas, A., & Matthews, F. E. (2011). Neuropathological correlates of late-life depression in older people. British Journal of Psychiatry, 198(2), 109-114. https://doi.org/10.1192/bjp.bp.110.078816
Journal Article Type | Article |
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Publication Date | Feb 1, 2011 |
Deposit Date | Dec 8, 2023 |
Journal | British Journal of Psychiatry |
Print ISSN | 0007-1250 |
Electronic ISSN | 1472-1465 |
Publisher | Royal College of Psychiatrists |
Volume | 198 |
Issue | 2 |
Pages | 109-114 |
DOI | https://doi.org/10.1192/bjp.bp.110.078816 |
Public URL | https://hull-repository.worktribe.com/output/4454931 |
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