Yu Tzu Wu
The longitudinal associations between ambient air pollution exposure and dementia in the UK: results from the cognitive function and ageing study II and Wales
Wu, Yu Tzu; Kitwiroon, Nutthida; Beevers, Sean; Barratt, Benjamin; Brayne, Carol; Cerin, Ester; Franklin, Rachel; Houlden, Vikki; Woods, Bob; Zied Abozied, Eman; Prina, Matthew; Matthews, Fiona
Authors
Nutthida Kitwiroon
Sean Beevers
Benjamin Barratt
Carol Brayne
Ester Cerin
Rachel Franklin
Vikki Houlden
Bob Woods
Eman Zied Abozied
Matthew Prina
Professor Fiona Matthews F.Matthews@hull.ac.uk
Pro-Vice-Chancellor Research and Enterprise
Abstract
Background: Air pollution has been recognised as a potential risk factor for dementia. Yet recent epidemiological research shows mixed evidence. The aim of this study is to investigate the longitudinal associations between ambient air pollution exposure and dementia in older people across five urban and rural areas in the UK. Methods: This study was based on two population-based cohort studies of 11329 people aged ≥ 65 in the Cognitive Function and Ageing Study II (2008–2011) and Wales (2011–2013). An algorithmic diagnosis method was used to identify dementia cases. Annual concentrations of four air pollutants (NO2, O3, PM10, PM2.5) were modelled for the year 2012 and linked via the participants’ postcodes. Multistate modelling was used to examine the effects of exposure to air pollutants on incident dementia incorporating death and adjusting for sociodemographic factors and area deprivation. A random-effect meta-analysis was carried out to summarise results from the current and nine existing cohort studies. Results: Higher exposure levels of NO2 (HR: 1.04; 95% CI: 0.94, 1.14), O3 (HR: 0.90; 95% CI: 0.70, 1.15), PM10 (HR: 1.17; 95% CI: 0.86, 1.58), PM2.5 (HR: 1.41; 95% CI: 0.71, 2.79) were not strongly associated with dementia in the two UK-based cohorts. Inconsistent directions and strengths of the associations were observed across the two cohorts, five areas, and nine existing studies. Conclusions: In contrast to the literature, this study did not find clear associations between air pollution and dementia. Future research needs to investigate how methodological and contextual factors can affect evidence in this field and clarity the influence of air pollution exposure on cognitive health over the lifecourse.
Citation
Wu, Y. T., Kitwiroon, N., Beevers, S., Barratt, B., Brayne, C., Cerin, E., Franklin, R., Houlden, V., Woods, B., Zied Abozied, E., Prina, M., & Matthews, F. (2024). The longitudinal associations between ambient air pollution exposure and dementia in the UK: results from the cognitive function and ageing study II and Wales. BMC public health, 24(1), Article 1233. https://doi.org/10.1186/s12889-024-18723-3
Journal Article Type | Article |
---|---|
Acceptance Date | Apr 28, 2024 |
Online Publication Date | May 4, 2024 |
Publication Date | May 4, 2024 |
Deposit Date | May 10, 2024 |
Publicly Available Date | May 14, 2024 |
Journal | BMC Public Health |
Print ISSN | 1471-2458 |
Electronic ISSN | 1471-2458 |
Publisher | Springer Verlag |
Peer Reviewed | Peer Reviewed |
Volume | 24 |
Issue | 1 |
Article Number | 1233 |
DOI | https://doi.org/10.1186/s12889-024-18723-3 |
Keywords | Dementia; Air pollution; Environmental risk factors; Public health; Cohort studies |
Public URL | https://hull-repository.worktribe.com/output/4664066 |
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© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which
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