All Outputs (21)

Adult lifespan cognitive variability in the cross-sectional cam-CAN cohort (2015)
Journal Article
Green, E., Shafto, M. A., Matthews, F. E., Cam-Can, & White, S. R. (2015). Adult lifespan cognitive variability in the cross-sectional cam-CAN cohort. International Journal of Environmental Research and Public Health, 12(12), 15516-15530. https://doi.org/10.3390/ijerph121215003

This study examines variability across the age span in cognitive performance in a cross-sectional, population-based, adult lifespan cohort from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) study (n = 2680). A key question we highlight i... Read More about Adult lifespan cognitive variability in the cross-sectional cam-CAN cohort.

Changes in health in England, with analysis by English regions and areas of deprivation, 1990-2013: A systematic analysis for the Global Burden of Disease Study 2013 (2015)
Journal Article
Newton, J. N., Briggs, A. D., Murray, C. J., Dicker, D., Foreman, K. J., Wang, H., …Davis, A. C. (2015). Changes in health in England, with analysis by English regions and areas of deprivation, 1990-2013: A systematic analysis for the Global Burden of Disease Study 2013. Lancet, 386(10010), 2257-2274. https://doi.org/10.1016/S0140-6736%2815%2900195-6

Background In the Global Burden of Disease Study 2013 (GBD 2013), knowledge about health and its determinants has been integrated into a comparable framework to inform health policy. Outputs of this analysis are relevant to current policy questions i... Read More about Changes in health in England, with analysis by English regions and areas of deprivation, 1990-2013: A systematic analysis for the Global Burden of Disease Study 2013.

The nuclear retention of transcription factor FOXO3a correlates with a DNA damage response and increased glutamine synthetase expression by astrocytes suggesting a neuroprotective role in the ageing brain (2015)
Journal Article
Fluteau, A., Ince, P. G., Minett, T., Matthews, F. E., Brayne, C., Garwood, C. J., …Simpson, J. E. (2015). The nuclear retention of transcription factor FOXO3a correlates with a DNA damage response and increased glutamine synthetase expression by astrocytes suggesting a neuroprotective role in the ageing brain. Neuroscience letters, 609, 11-17. https://doi.org/10.1016/j.neulet.2015.10.001

The accumulation of reactive oxygen species leading to oxidative damage and cell death plays an important role in a number of neurodegenerative disorders. FOXO3a, the main isoform of FOXO transcription factors, mediates the cellular response to oxida... Read More about The nuclear retention of transcription factor FOXO3a correlates with a DNA damage response and increased glutamine synthetase expression by astrocytes suggesting a neuroprotective role in the ageing brain.

The prevalence of mild cognitive impairment in diverse geographical and ethnocultural regions: The COSMIC Collaboration (2015)
Journal Article
Sachdev, P. S., Lipnicki, D. M., Kochan, N. A., Crawford, J. D., Thalamuthu, A., Andrews, G., …Lobo, E. (2015). The prevalence of mild cognitive impairment in diverse geographical and ethnocultural regions: The COSMIC Collaboration. PLoS ONE, 10(11), https://doi.org/10.1371/journal.pone.0142388

Background Changes in criteria and differences in populations studied and methodology have produced a wide range of prevalence estimates for mild cognitive impairment (MCI). Methods Uniform criteria were applied to harmonized data from 11 studies fro... Read More about The prevalence of mild cognitive impairment in diverse geographical and ethnocultural regions: The COSMIC Collaboration.

Community environment, cognitive impairment and dementia in later life: Results from the Cognitive Function and Ageing Study (2015)
Journal Article
Wu, Y. T., Prina, A. M., Jones, A. P., Barnes, L. E., Matthews, F. E., & Brayne, C. (2015). Community environment, cognitive impairment and dementia in later life: Results from the Cognitive Function and Ageing Study. Age and ageing, 44(6), 1005-1011. https://doi.org/10.1093/ageing/afv137

Background: few studies have investigated the impact of the community environment, as distinct from area deprivation, on cognition in later life. This study explores cross-sectional associations between cognitive impairment and dementia and environme... Read More about Community environment, cognitive impairment and dementia in later life: Results from the Cognitive Function and Ageing Study.

Idiosyncratic responding during movie-watching predicted by age differences in attentional control (2015)
Journal Article
Campbell, K. L., Shafto, M. A., Wright, P., Tsvetanov, K. A., Geerligs, L., Cusack, R., …Villis, L. (2015). Idiosyncratic responding during movie-watching predicted by age differences in attentional control. Neurobiology of Aging, 36(11), 3045-3055. https://doi.org/10.1016/j.neurobiolaging.2015.07.028

Much is known about how age affects the brain during tightly controlled, though largely contrived, experiments, but do these effects extrapolate to everyday life? Naturalistic stimuli, such as movies, closely mimic the real world and provide a window... Read More about Idiosyncratic responding during movie-watching predicted by age differences in attentional control.

Validation of existing diagnosis of autism in mainland China using standardised diagnostic instruments (2015)
Journal Article
Sun, X., Allison, C., Auyeung, B., Zhang, Z., Matthews, F. E., Baron-Cohen, S., & Brayne, C. (2015). Validation of existing diagnosis of autism in mainland China using standardised diagnostic instruments. Autism, 19(8), 1010-1017. https://doi.org/10.1177/1362361314556785

Research to date in mainland China has mainly focused on children with autistic disorder rather than Autism Spectrum Conditions and the diagnosis largely depended on clinical judgment without the use of diagnostic instruments. Whether children who ha... Read More about Validation of existing diagnosis of autism in mainland China using standardised diagnostic instruments.

Social activity, cognitive decline and dementia risk: A 20-year prospective cohort study Chronic Disease epidemiology (2015)
Journal Article
Marioni, R. E., Proust-Lima, C., Amieva, H., Brayne, C., Matthews, F. E., Dartigues, J. F., & Jacqmin-Gadda, H. (2015). Social activity, cognitive decline and dementia risk: A 20-year prospective cohort study Chronic Disease epidemiology. BMC public health, 15(1), https://doi.org/10.1186/s12889-015-2426-6

Background: Identifying modifiable lifestyle correlates of cognitive decline and risk of dementia is complex, particularly as few population-based longitudinal studies jointly model these interlinked processes. Recent methodological developments allo... Read More about Social activity, cognitive decline and dementia risk: A 20-year prospective cohort study Chronic Disease epidemiology.

State and trait components of functional connectivity: Individual differences vary with mental state (2015)
Journal Article
Geerligs, L., Rubinov, M., Tyler, L. K., Brayne, C., Bullmore, E. T., Calder, A. C., …Henson, R. N. (2015). State and trait components of functional connectivity: Individual differences vary with mental state. Journal of Neuroscience, 35(41), 13949-13961. https://doi.org/10.1523/JNEUROSCI.1324-15.2015

Resting-state functional connectivity, as measured by functional magnetic resonance imaging (fMRI), is often treated as a trait, used, for example, to draw inferences about individual differences in cognitive function, or differences between healthy... Read More about State and trait components of functional connectivity: Individual differences vary with mental state.

Subjective Memory Complaints are Involved in the Relationship between Mood and Mild Cognitive Impairment (2015)
Journal Article
Yates, J. A., Clare, L., Woods, R. T., & Matthews, F. E. (2015). Subjective Memory Complaints are Involved in the Relationship between Mood and Mild Cognitive Impairment. Journal of Alzheimer's Disease, 48(S1), S115-S123. https://doi.org/10.3233/JAD-150371

Subjective memory complaints (SMC) are a criterion in many definitions of mild cognitive impairment (MCI). However, there is controversy over whether this is useful and appropriate, as previous research has suggested that SMC may be a function of moo... Read More about Subjective Memory Complaints are Involved in the Relationship between Mood and Mild Cognitive Impairment.

Relocation at older age: Results from the Cognitive Function and Ageing Study (2015)
Journal Article
Wu, Y. T., Prina, A. M., Barnes, L. E., Matthews, F. E., & Brayne, C. (2015). Relocation at older age: Results from the Cognitive Function and Ageing Study. Journal of Public Health, 37(3), 480-487. https://doi.org/10.1093/pubmed/fdv050

Background Community environment might play an important role in supporting ageing in place. This paper aims to explore relocation at older age and its associations with individual and community level factors. Methods The postcodes of the 2424 people... Read More about Relocation at older age: Results from the Cognitive Function and Ageing Study.

Oxidative glial cell damage associated with white matter lesions in the aging human brain (2015)
Journal Article
Al-Mashhadi, S., Simpson, J. E., Heath, P. R., Dickman, M., Forster, G., Matthews, F. E., …Wharton, S. B. (2015). Oxidative glial cell damage associated with white matter lesions in the aging human brain. Brain Pathology, 25(5), 565-574. https://doi.org/10.1111/bpa.12216

White matter lesions (WML) are common in brain aging and are associated with dementia. We aimed to investigate whether oxidative DNA damage and occur in WML and in apparently normal white matter in cases with lesions. Tissue from WML and control whit... Read More about Oxidative glial cell damage associated with white matter lesions in the aging human brain.

Changing non-participation in epidemiological studies of older people: Evidence from the Cognitive Function and Ageing Study I and II (2015)
Journal Article
Gao, L., Green, E., Barnes, L. E., Brayne, C., Matthews, F. E., Robinson, L., & Arthur, A. (2015). Changing non-participation in epidemiological studies of older people: Evidence from the Cognitive Function and Ageing Study I and II. Age and ageing, 44(5), 867-873. https://doi.org/10.1093/ageing/afv101

Background: non-participation in epidemiological studies threatens the generalisability of findings. Objective: to investigate the change in non-participation between the Medical Research Council Cognitive Function and Ageing Study (CFAS) I and II. D... Read More about Changing non-participation in epidemiological studies of older people: Evidence from the Cognitive Function and Ageing Study I and II.

Prevalence of dementia in East Asia: A synthetic review of time trends (2015)
Journal Article
Wu, Y. T., Brayne, C., & Matthews, F. E. (2015). Prevalence of dementia in East Asia: A synthetic review of time trends. International journal of geriatric psychiatry, 30(8), 793-801. https://doi.org/10.1002/gps.4297

Objective This study aims to synthesise evidence on time trends of dementia prevalence in East Asian countries including Japan, China, South Korea and Taiwan and assess the impact of the societal changes on future prevalence. Method Relevant reviews... Read More about Prevalence of dementia in East Asia: A synthetic review of time trends.

Exploring the Underdiagnosis and Prevalence of Autism Spectrum Conditions in Beijing (2015)
Journal Article
Sun, X., Allison, C., Matthews, F. E., Zhang, Z., Auyeung, B., Baron-Cohen, S., & Brayne, C. (2015). Exploring the Underdiagnosis and Prevalence of Autism Spectrum Conditions in Beijing. Autism Research, 8(3), 250-260. https://doi.org/10.1002/aur.1441

Previous studies reported that the prevalence of Autism Spectrum Conditions (ASC) in mainland China is much lower than estimates from developed countries (around 1%). The aim of the study is to apply current screening and standardized diagnostic inst... Read More about Exploring the Underdiagnosis and Prevalence of Autism Spectrum Conditions in Beijing.

A neuronal DNA damage response is detected at the earliest stages of Alzheimer's neuropathology and correlates with cognitive impairment in the Medical Research Council's Cognitive Function and Ageing Study ageing brain cohort (2015)
Journal Article
Simpson, J. E., Ince, P. G., Matthews, F. E., Shaw, P. J., Heath, P. R., Brayne, C., …Wharton, S. B. (2015). A neuronal DNA damage response is detected at the earliest stages of Alzheimer's neuropathology and correlates with cognitive impairment in the Medical Research Council's Cognitive Function and Ageing Study ageing brain cohort. Neuropathology and Applied Neurobiology, 41(4), 483-496. https://doi.org/10.1111/nan.12202

Aims: Population-based studies have shown that approximately 20% of the ageing population (aged 65 years and over) with dementia have little or no classical Alzheimer-type neuropathology. Cumulative DNA damage and a reduced capacity of DNA repair may... Read More about A neuronal DNA damage response is detected at the earliest stages of Alzheimer's neuropathology and correlates with cognitive impairment in the Medical Research Council's Cognitive Function and Ageing Study ageing brain cohort.

Alpha-synucleinopathy and neuropsychological symptoms in a population-based cohort of the elderly (2015)
Journal Article
Zaccai, J., Brayne, C., Matthews, F. E., & Ince, P. G. (2015). Alpha-synucleinopathy and neuropsychological symptoms in a population-based cohort of the elderly. Alzheimer's Research and Therapy, 7(1), https://doi.org/10.1186/s13195-015-0101-x

Introduction: Studies with strong selection biases propose that alpha-synucleinopathy (AS) spreads upwards and downwards in the neuraxis from the medulla, that amygdala-dominant AS is strongly associated with Alzheimer's disease (AD), and that a more... Read More about Alpha-synucleinopathy and neuropsychological symptoms in a population-based cohort of the elderly.

A reduced astrocyte response to β-amyloid plaques in the ageing brain associates with cognitive impairment (2015)
Journal Article
Mathur, R., Ince, P. G., Minett, T., Garwood, C. J., Shaw, P. J., Matthews, F. E., …Wharton, S. B. (2015). A reduced astrocyte response to β-amyloid plaques in the ageing brain associates with cognitive impairment. PLoS ONE, 10(2), https://doi.org/10.1371/journal.pone.0118463

Aims β-amyloid (Aβ) plaques are a key feature of Alzheimer's disease pathology but correlate poorly with dementia. They are associated with astrocytes which may modulate the effect of Aβ-deposition on the neuropil. This study characterised the astroc... Read More about A reduced astrocyte response to β-amyloid plaques in the ageing brain associates with cognitive impairment.

Dementia prediction for people with stroke in populations: is mild cognitive impairment a useful concept? (2015)
Journal Article
Stephan, B. C., Minett, T., Terrera, G. M., Matthews, F. E., & Brayne, C. (2015). Dementia prediction for people with stroke in populations: is mild cognitive impairment a useful concept?. Age and ageing, 44(1), 78-83. https://doi.org/10.1093/AGEING/AFU085

Background: criteria for mild cognitive impairment (MCI) capture an intermediate cognitive state between normal ageing and dementia, associated with increased dementia risk. Whether criteria for MCI are applicable in the context of stroke and can be... Read More about Dementia prediction for people with stroke in populations: is mild cognitive impairment a useful concept?.

Older people, the natural environment and common mental disorders: Cross-sectional results from the Cognitive Function and Ageing Study (2015)
Journal Article
Wu, Y. T., Prina, A. M., Jones, A., Matthews, F. E., & Brayne, C. (2015). Older people, the natural environment and common mental disorders: Cross-sectional results from the Cognitive Function and Ageing Study. BMJ open, 5(9), https://doi.org/10.1136/bmjopen-2015-007936

Objectives: To explore the hypothesis that higher exposure to natural environments in local areas is associated with a lower odds of depression and anxiety in later life. Design: A cross-sectional study based on the year-10 interview of the Medical R... Read More about Older people, the natural environment and common mental disorders: Cross-sectional results from the Cognitive Function and Ageing Study.