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A comparison over 2 decades of disability-free life expectancy at age 65 years for those with long-term conditions in England: Analysis of the 2 longitudinal Cognitive Function and Ageing Studies (2022)
Journal Article
Bennett, H. Q., Kingston, A., Lourida, I., Robinson, L., Corner, L., Brayne, C., …Jagger, C. (2022). A comparison over 2 decades of disability-free life expectancy at age 65 years for those with long-term conditions in England: Analysis of the 2 longitudinal Cognitive Function and Ageing Studies. PLoS Medicine, 19(3), Article e1003936. https://doi.org/10.1371/journal.pmed.1003936

Background Previous research has examined the improvements in healthy years if different health conditions are eliminated, but often with cross-sectional data, or for a limited number of conditions. We used longitudinal data to estimate disability-fr... Read More about A comparison over 2 decades of disability-free life expectancy at age 65 years for those with long-term conditions in England: Analysis of the 2 longitudinal Cognitive Function and Ageing Studies.

Longitudinal Trajectories of Quality of Life among People with Mild-To-Moderate Dementia: A Latent Growth Model Approach with IDEAL Cohort Study Data (2022)
Journal Article
Clare, L., Gamble, L. D., Martyr, A., Sabatini, S., Nelis, S. M., Quinn, C., …Matthews, F. E. (2022). Longitudinal Trajectories of Quality of Life among People with Mild-To-Moderate Dementia: A Latent Growth Model Approach with IDEAL Cohort Study Data. The Journals of Gerontology, Series B: Psychological Sciences and Social Sciences, 77(6), 1037-1050. https://doi.org/10.1093/geronb/gbac022

Objectives: We aimed to examine change over time in self-rated quality of life (QoL) in people with mild-To-moderate dementia and identify subgroups with distinct QoL trajectories. Methods: We used data from people with mild-To-moderate dementia foll... Read More about Longitudinal Trajectories of Quality of Life among People with Mild-To-Moderate Dementia: A Latent Growth Model Approach with IDEAL Cohort Study Data.

A Comparison of Well-Being of Carers of People with Dementia and Their Ability to Manage Before and During the COVID-19 Pandemic: Findings from the IDEAL Study (2022)
Journal Article
Gamble, L. D., Parker, S., Quinn, C., Bennett, H. Q., Martyr, A., Sabatini, S., Pentecost, C., Collins, R., Dawson, E., Hunt, A., Allan, L., Burns, A., Litherland, R., Victor, C., Matthews, F. E., & Clare, L. (2022). A Comparison of Well-Being of Carers of People with Dementia and Their Ability to Manage Before and During the COVID-19 Pandemic: Findings from the IDEAL Study. Journal of Alzheimer's Disease, 88(2), 679-692. https://doi.org/10.3233/JAD-220221

Background: Social restriction measures imposed to curb the spread of COVID-19 in the United Kingdom impacted on carers of people with dementia, limiting access to support services and increasing perceived burden of caring. Few studies have compared... Read More about A Comparison of Well-Being of Carers of People with Dementia and Their Ability to Manage Before and During the COVID-19 Pandemic: Findings from the IDEAL Study.

Impact of COVID-19 on 'Living Well' with Mild-to-Moderate Dementia in the Community: Findings from the IDEAL Cohort (2022)
Journal Article
Clare, L., Martyr, A., Gamble, L. D., Pentecost, C., Collins, R., Dawson, E., …Victor, C. (2022). Impact of COVID-19 on 'Living Well' with Mild-to-Moderate Dementia in the Community: Findings from the IDEAL Cohort. Journal of Alzheimer's Disease, 85(2), 921-936. https://doi.org/10.3233/JAD-215095

Background: Negative impacts of the COVID-19 pandemic on people with dementia have been widely-documented, but most studies have relied on carer reports and few have compared responses to information collected before the pandemic. Objective: We aimed... Read More about Impact of COVID-19 on 'Living Well' with Mild-to-Moderate Dementia in the Community: Findings from the IDEAL Cohort.

The Use and Costs of Paid and Unpaid Care for People with Dementia: Longitudinal Findings from the IDEAL Cohort (2022)
Journal Article
Henderson, C., Knapp, M., Martyr, A., Gamble, L. D., Nelis, S. M., Quinn, C., …Clare, L. (2022). The Use and Costs of Paid and Unpaid Care for People with Dementia: Longitudinal Findings from the IDEAL Cohort. Journal of Alzheimer's Disease, 86(1), 135-153. https://doi.org/10.3233/JAD-215117

Background: The drivers of costs of care for people with dementia are not well understood and little is known on the costs of care for those with rarer dementias. Objective: To characterize use and costs of paid and unpaid care over time in a cohort... Read More about The Use and Costs of Paid and Unpaid Care for People with Dementia: Longitudinal Findings from the IDEAL Cohort.

Static Socio-Ecological COVID-19 Vulnerability Index and Vaccine Hesitancy Index for England (2021)
Journal Article
Welsh, C. E., Sinclair, D. R., & Matthews, F. E. (2022). Static Socio-Ecological COVID-19 Vulnerability Index and Vaccine Hesitancy Index for England. The Lancet Regional Health Europe, 14, Article 100296. https://doi.org/10.1016/j.lanepe.2021.100296

Background: Population characteristics can be used to infer vulnerability of communities to COVID-19, or to the likelihood of high levels of vaccine hesitancy. Communities harder hit by the virus, or at risk of being so, stand to benefit from greater... Read More about Static Socio-Ecological COVID-19 Vulnerability Index and Vaccine Hesitancy Index for England.

Frailty among Older Adults and Its Distribution in England (2021)
Journal Article
Sinclair, D. R., Maharani, A., Chandola, T., Bower, P., Hanratty, B., Nazroo, J., …Pendleton, N. (2022). Frailty among Older Adults and Its Distribution in England. The Journal of frailty & aging, 11(2), 163-168. https://doi.org/10.14283/jfa.2021.55

Background: Information on the spatial distribution of the frail population is crucial to inform service planning in health and social care. Objectives: To estimate small-area frailty prevalence among older adults using survey data. To assess whether... Read More about Frailty among Older Adults and Its Distribution in England.

Psychological Processes in Adapting to Dementia: Illness Representations Among the IDEAL Cohort (2021)
Journal Article
Clare, L., Gamble, L. D., Martyr, A., Quinn, C., Litherland, R., Morris, R. G., …Matthews, F. E. (2022). Psychological Processes in Adapting to Dementia: Illness Representations Among the IDEAL Cohort. Psychology and Aging, 37(4), 524-541. https://doi.org/10.1037/pag0000650

How people understand and adapt to living with dementia may influence well-being. Leventhal’s Common Sense Model (CSM) of Self-Regulation provides a theoretical basis for exploring this process. We used crosssectional and longitudinal data from 1,109... Read More about Psychological Processes in Adapting to Dementia: Illness Representations Among the IDEAL Cohort.

Neurodegenerative brain changes are associated with area deprivation in the United Kingdom: findings from the Brains for Dementia Research study (2021)
Journal Article
Hamilton, C. A., Matthews, F. E., Erskine, D., Attems, J., & Thomas, A. J. (2021). Neurodegenerative brain changes are associated with area deprivation in the United Kingdom: findings from the Brains for Dementia Research study. Acta Neuropathologica Communications, 9(1), Article 198. https://doi.org/10.1186/s40478-021-01301-8

Socioeconomic disadvantage is associated with greater risk of dementia. This has been theorised to reflect inequalities in cognitive reserve, healthcare access, lifestyle, and other health factors which may contribute to the clinical manifestation of... Read More about Neurodegenerative brain changes are associated with area deprivation in the United Kingdom: findings from the Brains for Dementia Research study.

Can vaccination roll-out be more equitable if population risk is taken into account? (2021)
Journal Article
Sinclair, D. R., Maharani, A., Stow, D., Welsh, C. E., & Matthews, F. E. (2021). Can vaccination roll-out be more equitable if population risk is taken into account?. PLoS ONE, 16(November), Article e0259990. https://doi.org/10.1371/journal.pone.0259990

Background COVID-19 vaccination in many countries, including England, has been prioritised primarily by age. However, people of the same age can have very different health statuses. Frailty is a commonly used metric of health and has been found to be... Read More about Can vaccination roll-out be more equitable if population risk is taken into account?.

Slowing on quantitative EEG is associated with transition to dementia in mild cognitive impairment (2021)
Journal Article
Hamilton, C. A., Schumacher, J., Matthews, F., Taylor, J. P., Allan, L., Barnett, N., …Thomas, A. J. (2021). Slowing on quantitative EEG is associated with transition to dementia in mild cognitive impairment. International Psychogeriatrics, 33(12), 1321-1325. https://doi.org/10.1017/S1041610221001083

Electroencephalographic (EEG) abnormalities are greater in mild cognitive impairment (MCI) with Lewy bodies (MCI-LB) than in MCI due to Alzheimer's disease (MCI-AD) and may anticipate the onset of dementia. We aimed to assess whether quantitative EEG... Read More about Slowing on quantitative EEG is associated with transition to dementia in mild cognitive impairment.

The relationship between deprivation and frailty trajectories over 1 year and at the end of life: A case-control study (2021)
Journal Article
Stow, D., Hanratty, B., & Matthews, F. E. (2022). The relationship between deprivation and frailty trajectories over 1 year and at the end of life: A case-control study. Journal of Public Health, 44(4), 844-850. https://doi.org/10.1093/pubmed/fdab320

Background: We investigated the association between area-level, multi-domain deprivation and frailty trajectories in the last year of life and over 1 year in a matched non-end-of-life sample. Methods: A 1-year longitudinal case-control study using pr... Read More about The relationship between deprivation and frailty trajectories over 1 year and at the end of life: A case-control study.

National Early Warning Scores and COVID-19 deaths in care homes: An ecological time-series study (2021)
Journal Article
Stow, D., Barker, R. O., Matthews, F. E., & Hanratty, B. (2021). National Early Warning Scores and COVID-19 deaths in care homes: An ecological time-series study. BMJ open, 11(9), Article e045579. https://doi.org/10.1136/bmjopen-2020-045579

Objectives To investigate whether National Early Warning Scores (NEWS/NEWS2) could contribute to COVID-19 surveillance in care homes. Setting 460 care home units using the same software package to collect data on residents, from 46 local authority ar... Read More about National Early Warning Scores and COVID-19 deaths in care homes: An ecological time-series study.

The contribution of multiple long-term conditions to widening inequalities in disability-free life expectancy over two decades: Longitudinal analysis of two cohorts using the Cognitive Function and Ageing Studies (2021)
Journal Article
Bennett, H. Q., Kingston, A., Lourida, I., Robinson, L., Corner, L., Brayne, C. E., …Jagger, C. (2021). The contribution of multiple long-term conditions to widening inequalities in disability-free life expectancy over two decades: Longitudinal analysis of two cohorts using the Cognitive Function and Ageing Studies. EClinicalMedicine, 39, Article 101041. https://doi.org/10.1016/j.eclinm.2021.101041

Background:: Disability-free life expectancy (DFLE) inequalities by socioeconomic deprivation are widening, alongside rising prevalence of multiple long-term conditions (MLTCs). We use longitudinal data to assess whether MLTCs contribute to the widen... Read More about The contribution of multiple long-term conditions to widening inequalities in disability-free life expectancy over two decades: Longitudinal analysis of two cohorts using the Cognitive Function and Ageing Studies.

BIOlogical Factors that Limit sustAined Remission in rhEumatoid arthritis (the BIO-FLARE study): protocol for a non-randomised longitudinal cohort study (2021)
Journal Article
Rayner, F., Anderson, A. E., Baker, K. F., Buckley, C. D., Dyke, B., Fenton, S., …Isaacs, J. D. (2021). BIOlogical Factors that Limit sustAined Remission in rhEumatoid arthritis (the BIO-FLARE study): protocol for a non-randomised longitudinal cohort study. BMC Rheumatology, 5(1), Article 22. https://doi.org/10.1186/s41927-021-00194-3

Background: Our knowledge of immune-mediated inflammatory disease (IMID) aetiology and pathogenesis has improved greatly over recent years, however, very little is known of the factors that trigger disease relapses (flares), converting diseases from... Read More about BIOlogical Factors that Limit sustAined Remission in rhEumatoid arthritis (the BIO-FLARE study): protocol for a non-randomised longitudinal cohort study.

Developing and evaluating a frailty index for older South Africans - Findings from the HAALSI study (2021)
Journal Article
Barker, F. J., Davies, J. I., Xavier Gomez-Olive, F., Kahn, K., Matthews, F. E., Payne, C. F., …Witham, M. D. (2021). Developing and evaluating a frailty index for older South Africans - Findings from the HAALSI study. Age and ageing, 50(6), 2167-2173. https://doi.org/10.1093/ageing/afab111

Background: despite rapid population ageing, few studies have investigated frailty in older people in sub-Saharan Africa. We tested a cumulative deficit frailty index in a population of older people from rural South Africa. Methods: analysis of cross... Read More about Developing and evaluating a frailty index for older South Africans - Findings from the HAALSI study.

Quantitative checklist for autism in toddlers (Q-CHAT). A population screening study with follow-up: The case for multiple time-point screening for autism (2021)
Journal Article
Allison, C., Matthews, F. E., Ruta, L., Pasco, G., Soufer, R., Brayne, C., Charman, T., & Baron-Cohen, S. (2021). Quantitative checklist for autism in toddlers (Q-CHAT). A population screening study with follow-up: The case for multiple time-point screening for autism. BMJ Paediatrics Open, 5(1), Article e000700. https://doi.org/10.1136/bmjpo-2020-000700

Objective This is a prospective population screening study for autism in toddlers aged 18-30 months old using the Quantitative Checklist for Autism in Toddlers (Q-CHAT), with follow-up at age 4. Design Observational study. Setting Luton, Bedfordshire... Read More about Quantitative checklist for autism in toddlers (Q-CHAT). A population screening study with follow-up: The case for multiple time-point screening for autism.

Hospitalisation without delirium is not associated with cognitive decline in a population-based sample of older people-results from a nested, longitudinal cohort study (2021)
Journal Article
Richardson, S. J., Lawson, R., Davis, D. H., Stephan, B. C., Robinson, L., Matthews, F. E., …Allan, L. M. (2021). Hospitalisation without delirium is not associated with cognitive decline in a population-based sample of older people-results from a nested, longitudinal cohort study. Age and ageing, 50(5), 1675-1681. https://doi.org/10.1093/ageing/afab068

Background: Acute hospitalisation and delirium have individually been shown to adversely affect trajectories of cognitive decline but have not previously been considered together. This work aimed to explore the impact on cognition of hospital admissi... Read More about Hospitalisation without delirium is not associated with cognitive decline in a population-based sample of older people-results from a nested, longitudinal cohort study.

Progression to Dementia in Mild Cognitive Impairment with Lewy Bodies or Alzheimer Disease (2021)
Journal Article
Hamilton, C. A., Matthews, F. E., Donaghy, P. C., Taylor, J. P., O'Brien, J. T., Barnett, N., …Thomas, A. J. (2021). Progression to Dementia in Mild Cognitive Impairment with Lewy Bodies or Alzheimer Disease. Neurology, 96(22), E2685-E2693. https://doi.org/10.1212/WNL.0000000000012024

ObjectiveTo determine whether mild cognitive impairment with Lewy bodies or mild cognitive impairment with Alzheimer disease differ in their rates of clinical progression to dementia, we undertook longitudinal observation of mild cognitive impairment... Read More about Progression to Dementia in Mild Cognitive Impairment with Lewy Bodies or Alzheimer Disease.