Quantitative checklist for autism in toddlers (Q-CHAT). A population screening study with follow-up: The case for multiple time-point screening for autism

Allison, Carrie; Matthews, Fiona E.; Ruta, Liliana; Pasco, Greg; Soufer, Renee; Brayne, Carol; Charman, Tony; Baron-Cohen, Simon

Abstract

Objective This is a prospective population screening study for autism in toddlers aged 18-30 months old using the Quantitative Checklist for Autism in Toddlers (Q-CHAT), with follow-up at age 4. Design Observational study. Setting Luton, Bedfordshire and Cambridgeshire in the UK. Participants 13 070 toddlers registered on the Child Health Surveillance Database between March 2008 and April 2009, with follow-up at age 4; 3770 (29%) were screened for autism at 18-30 months using the Q-CHAT and the Childhood Autism Spectrum Test (CAST) at follow-up at age 4. Interventions A stratified sample across the Q-CHAT score distribution was invited for diagnostic assessment (phase 1). The 4-year follow-up included the CAST and the Checklist for Referral (CFR). All with CAST ≥15, phase 1 diagnostic assessment or with developmental concerns on the CFR were invited for diagnostic assessment (phase 2). Standardised diagnostic assessment at both time-points was conducted to establish the test accuracy of the Q-CHAT. Main outcome measures Consensus diagnostic outcome at phase 1 and phase 2. Results At phase 1, 3770 Q-CHATs were returned (29% response) and 121 undertook diagnostic assessment, of whom 11 met the criteria for autism. All 11 screened positive on the Q-CHAT. The positive predictive value (PPV) at a cut-point of 39 was 17% (95% CI 8% to 31%). At phase 2, 2005 of 3472 CASTs and CFRs were returned (58% response). 159 underwent diagnostic assessment, including 82 assessed in phase 1. All children meeting the criteria for autism identified via the Q-CHAT at phase 1 also met the criteria at phase 2. The PPV was 28% (95% CI 15% to 46%) after phase 1 and phase 2. Conclusions The Q-CHAT can be used at 18-30 months to identify autism and enable accelerated referral for diagnostic assessment. The low PPV suggests that for every true positive there would, however, be ∼4-5 false positives. At follow-up, new cases were identified, illustrating the need for continued surveillance and rescreening at multiple time-points using developmentally sensitive instruments. Not all children who later receive a diagnosis of autism are detectable during the toddler period.

Citation

Allison, C., Matthews, F. E., Ruta, L., Pasco, G., Soufer, R., Brayne, C., Charman, T., & Baron-Cohen, S. (2021). Quantitative checklist for autism in toddlers (Q-CHAT). A population screening study with follow-up: The case for multiple time-point screening for autism. BMJ Paediatrics Open, 5(1), Article e000700. https://doi.org/10.1136/bmjpo-2020-000700

• Journal Article Type: Article
• Acceptance Date: Apr 22, 2021
• Online Publication Date: May 28, 2021
• Publication Date: May 28, 2021
• Deposit Date: Sep 5, 2024
• Publicly Available Date: Sep 5, 2024
• Journal: BMJ Paediatrics Open
• Electronic ISSN: 2399-9772
• Publisher: BMJ Publishing Group
• Peer Reviewed: Peer Reviewed
• Volume: 5
• Issue: 1
• Article Number: e000700
• DOI: https://doi.org/10.1136/bmjpo-2020-000700
• Public URL: https://hull-repository.worktribe.com/output/4451336