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Survival times in people with dementia: Analysis from population based cohort study with 14 year follow-up (2008)
Journal Article
Xie, J., Brayne, C., & Matthews, F. E. (2008). Survival times in people with dementia: Analysis from population based cohort study with 14 year follow-up. BMJ, 336(7638), 258-262. https://doi.org/10.1136/bmj.39433.616678.25

Objectives: To provide estimates of survival after onset of dementia by age, sex, self reported health, disability, and severity of cognitive impairment. Design: Analysis of participants from prospective population based cohort study in 1991-2003, wi... Read More about Survival times in people with dementia: Analysis from population based cohort study with 14 year follow-up.

Community-level socio-economic status and cognitive and functional impairment in the older population (2008)
Journal Article
Basta, N. E., Matthews, F. E., Chatfield, M. D., & Brayne, C. (2008). Community-level socio-economic status and cognitive and functional impairment in the older population. European Journal of Public Health, 18(1), 48-54. https://doi.org/10.1093/eurpub/ckm076

Background: This study aimed to determine if people living in communities with higher socio-economic deprivation are at an increased risk of cognitive and functional impairment even after controlling for the effects of individual socio-economic statu... Read More about Community-level socio-economic status and cognitive and functional impairment in the older population.

Dementia and survival in parkinson disease: A 12-year population study (2008)
Journal Article
Buter, T. C., van den Hout, A., Matthews, F. E., Larsen, J. P., Brayne, C., & Aarsland, D. (2008). Dementia and survival in parkinson disease: A 12-year population study. Neurology, 70(13), 1017-1022. https://doi.org/10.1212/01.wnl.0000306632.43729.24

The risk for dementia in Parkinson disease (PD) is high, with important clinical consequences for patients with PD. However, the absolute risk of dementia and how it affects survival in PD are not known. Such questions are important for patients, the... Read More about Dementia and survival in parkinson disease: A 12-year population study.

Patterns and stages of α-synucleinopathy: Relevance in a population-based cohort (2008)
Journal Article
Zaccai, J., Brayne, C., McKeith, I., Matthews, F., & Ince, P. G. (2008). Patterns and stages of α-synucleinopathy: Relevance in a population-based cohort. Neurology, 70(13), 1042-1048. https://doi.org/10.1212/01.wnl.0000306697.48738.b6

It is proposed that α-synucleinopathy (AS) initially affects the medulla oblongata and progresses to more rostral brain areas in a hierarchical sequence (“Braak hypothesis”). Predominant involvement of the amygdala is also described. This study exami... Read More about Patterns and stages of α-synucleinopathy: Relevance in a population-based cohort.

Erratum: Prevalence of depression in older people in England and Wales: The MRC CFA Study (Psychological Medicine (2007) DOI: 10.1017/S0033291707000372) (2007)
Journal Article
McDougall, F. A., Kvaal, K., Matthews, F. E., Paykel, E., Jones, P. B., Dewey, M. E., & Brayne, C. (2007). Erratum: Prevalence of depression in older people in England and Wales: The MRC CFA Study (Psychological Medicine (2007) DOI: 10.1017/S0033291707000372). Psychological Medicine, 37(12), 1796. https://doi.org/10.1017/S0033291707001109

Microglial activation in white matter lesions and nonlesional white matter of ageing brains (2007)
Journal Article
Simpson, J. E., Ince, P. G., Higham, C. E., Gelsthorpe, C. H., Fernando, M. S., Matthews, F., Forster, G., O'Brien, J. T., Barber, R., Kalaria, R. N., Brayne, C., Shaw, P. J., Stoeber, K., Williams, G. H., Lewis, C. E., & Wharton, S. B. (2007). Microglial activation in white matter lesions and nonlesional white matter of ageing brains. Neuropathology and Applied Neurobiology, 33(6), 670-683. https://doi.org/10.1111/j.1365-2990.2007.00890.x

White matter lesions (WML), a common feature in brain ageing, are classified as periventricular (PVL) or deep subcortical (DSCL), depending on their anatomical location. Microglial activation is implicated in a number of neurodegenerative diseases, b... Read More about Microglial activation in white matter lesions and nonlesional white matter of ageing brains.

The epidemiology of low vision and blindness associated with trichiasis in southern Sudan (2007)
Journal Article
Ngondi, J., Reacher, M., Matthews, F., Ole-Sempele, F., Onsarigo, A., Matende, I., Baba, S., Brayne, C., & Emerson, P. (2007). The epidemiology of low vision and blindness associated with trichiasis in southern Sudan. BMC Ophthalmology, 7, https://doi.org/10.1186/1471-2415-7-12

Background. We investigated vision status associated with trachomatous trichiasis (TT) and explored age-sex patterns of low vision and blindness associated with trichiasis in Mankien district of southern Sudan where trachoma prevention and trichiasis... Read More about The epidemiology of low vision and blindness associated with trichiasis in southern Sudan.

Early cognitive change in the general population: How do different definitions work? (2007)
Journal Article
Stephan, B. C., Matthews, F. E., McKeith, I. G., Bond, J., & Brayne, C. (2007). Early cognitive change in the general population: How do different definitions work?. Journal of the American Geriatrics Society, 55(10), 1534-1540. https://doi.org/10.1111/j.1532-5415.2007.01386.x

OBJECTIVES: To explore the application of existing classifications of mild cognitive impairment (MCI) and associated states in a large population sample. DESIGN: Prospective cohort study, baseline phase (cross-sectional analysis). SETTING: Large-scal... Read More about Early cognitive change in the general population: How do different definitions work?.

Prevalence and symptomatology of depression in older people living in institutions in England and Wales (2007)
Journal Article
McDougall, F. A., Matthews, F. E., Kvaal, K., Dewey, M. E., & Brayne, C. (2007). Prevalence and symptomatology of depression in older people living in institutions in England and Wales. Age and ageing, 36(5), 562-568. https://doi.org/10.1093/ageing/afm111

Background: Epidemiological studies have shown that depression is common in institutional settings. However, the symptomatology of depression in this group has not been compared to those living in the community. Aims: To estimate the prevalence of de... Read More about Prevalence and symptomatology of depression in older people living in institutions in England and Wales.

Cohort differences in disease and disability in the young-old: Findings from the MRC Cognitive Function and Ageing Study (MRC-CFAS) (2007)
Journal Article
Jagger, C., Matthews, R. J., Matthews, F. E., Spiers, N. A., Nickson, J., Paykel, E. S., Huppert, F. A., & Brayne, C. (2007). Cohort differences in disease and disability in the young-old: Findings from the MRC Cognitive Function and Ageing Study (MRC-CFAS). BMC public health, 7, https://doi.org/10.1186/1471-2458-7-156

Background. Projections of health and social care need are highly sensitive to assumptions about cohort trends in health and disability. We use a repeated population-based cross-sectional study from the Cambridgeshire centre of the UK Medical Researc... Read More about Cohort differences in disease and disability in the young-old: Findings from the MRC Cognitive Function and Ageing Study (MRC-CFAS).

White matter lesions in an unselected cohort of the elderly: Astrocytic, microglial and oligodendrocyte precursor cell responses (2007)
Journal Article
Simpson, J. E., Fernando, M. S., Clark, L., Ince, P. G., Matthews, F., Forster, G., O'Brien, J. T., Barber, R., Kalaria, R. N., Brayne, C., Shaw, P. J., Lewis, C. E., & Wharton, S. B. (2007). White matter lesions in an unselected cohort of the elderly: Astrocytic, microglial and oligodendrocyte precursor cell responses. Neuropathology and Applied Neurobiology, 33(4), 410-419. https://doi.org/10.1111/j.1365-2990.2007.00828.x

Hyperintense lesions are frequently identified in T2-weighted magnetic resonance images (MRI) in the ageing brain. The pathological correlate and pathogenesis of white matter lesions (WML) remain unclear, and it is uncertain whether pathology and pat... Read More about White matter lesions in an unselected cohort of the elderly: Astrocytic, microglial and oligodendrocyte precursor cell responses.

Reaching the population with dementia drugs: What are the challenges? (2007)
Journal Article
Matthews, F. E., McKeith, I., Bond, J., & Brayne, C. (2007). Reaching the population with dementia drugs: What are the challenges?. International journal of geriatric psychiatry, 22(7), 627-631. https://doi.org/10.1002/gps.1720

Background: Systematic evidence became available in the late 1990s on efficacy of cholinesterase inhibitors (CHEIs) for patients with mild to moderate Alzheimer's disease (AI)) and they began to be used sporadically. Since January 2001 UK based guide... Read More about Reaching the population with dementia drugs: What are the challenges?.

Using the mini-mental state examination for tracking cognition in the older population based on longitudinal data (2007)
Journal Article
Chatfield, M., Matthews, F. E., & Brayne, C. (2007). Using the mini-mental state examination for tracking cognition in the older population based on longitudinal data. Journal of the American Geriatrics Society, 55(7), 1066-1071. https://doi.org/10.1111/j.1532-5415.2007.01216.x

OBJECTIVES: To estimate population norms for use in assessment of individuals in relation to their age-matched peers using true longitudinal patterns of decline. DESIGN: Longitudinal study of 10 years of follow-up data from the Medical Research Counc... Read More about Using the mini-mental state examination for tracking cognition in the older population based on longitudinal data.

Educational differences in the dynamics of disability incidence, recovery and mortality: Findings from the MRC Cognitive Function and Ageing Study (MRC CFAS) (2007)
Journal Article
Jagger, C., Matthews, R., Melzer, D., Matthews, F., & Brayne, C. (2007). Educational differences in the dynamics of disability incidence, recovery and mortality: Findings from the MRC Cognitive Function and Ageing Study (MRC CFAS). International Journal of Epidemiology, 36(2), 358-365. https://doi.org/10.1093/ije/dyl307

Background: This study aims to establish the extent of educational differences in the disability transitions of incidence, recovery and mortality in people aged 65 years and over, whether these can be explained by differentials in disease burden and... Read More about Educational differences in the dynamics of disability incidence, recovery and mortality: Findings from the MRC Cognitive Function and Ageing Study (MRC CFAS).

Blindness survey methods: Response from Sudan study authors [7] (2007)
Journal Article
Ngondi, J., Reacher, M., Brayne, C., Ole-Sempele, F., Onsarigo, A., Matende, I., Baba, S., Matthews, F., & Emerson, P. M. (2007). Blindness survey methods: Response from Sudan study authors [7]. PLoS Medicine, 4(2), 0395-0396. https://doi.org/10.1371/journal.pmed.0040086

Prevalence of depression in older people in England and Wales: The MRC CFA Study (2007)
Journal Article
McDougall, F. A., Kvaal, K., Matthews, F. E., Paykel, E., Jones, P. B., Dewey, M. E., & Brayne, C. (2007). Prevalence of depression in older people in England and Wales: The MRC CFA Study. Psychological Medicine, 37(12), 1787-1795. https://doi.org/10.1017/S0033291707000372

Background. Depression in old age is an important public health problem. The aims of this study were to report the prevalence of depression in the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS), a community-based, cohort. Met... Read More about Prevalence of depression in older people in England and Wales: The MRC CFA Study.

Prevalence of risk factors and severity of active trachoma in Southern Sudan: An ordinal analysis (2007)
Journal Article
Ngondi, J., Matthews, F., Reacher, M., Onsarigo, A., Matende, I., Baba, S., Brayne, C., Zingeser, J., & Emerson, P. (2007). Prevalence of risk factors and severity of active trachoma in Southern Sudan: An ordinal analysis. American Journal of Tropical Medicine and Hygiene, 77(1), 126-132. https://doi.org/10.4269/ajtmh.2007.77.126

We aimed to investigate prevalence of potential risk factors, and associations between risk factors and active trachoma in southern Sudan. Surveys were undertaken in ten sites and children aged 1-9 years examined for trachoma. Risk factors were asses... Read More about Prevalence of risk factors and severity of active trachoma in Southern Sudan: An ordinal analysis.