All Outputs (375)

Increasing prevalence of anticholinergic medication use in older people in England over 20 years: Cognitive function and ageing study i and II (2020)
Journal Article
Grossi, C. M., Richardson, K., Savva, G. M., Fox, C., Arthur, A., Loke, Y. K., Steel, N., Brayne, C., Matthews, F. E., Robinson, L., Myint, P. K., & Maidment, I. D. (2020). Increasing prevalence of anticholinergic medication use in older people in England over 20 years: Cognitive function and ageing study i and II. BMC Geriatrics, 20(1), Article 267. https://doi.org/10.1186/s12877-020-01657-x

Background: Anticholinergic medication use is linked with increased cognitive decline, dementia, falls and mortality, and their use should be limited in older people. Here we estimate the prevalence of anticholinergic use in England's older populatio... Read More about Increasing prevalence of anticholinergic medication use in older people in England over 20 years: Cognitive function and ageing study i and II.

Education and the moderating roles of age, sex, ethnicity and apolipoprotein epsilon 4 on the risk of cognitive impairment (2020)
Journal Article
Makkar, S. R., Lipnicki, D. M., Crawford, J. D., Kochan, N. A., Castro-Costa, E., Lima-Costa, M. F., Diniz, B. S., Brayne, C., Stephan, B., Matthews, F., Llibre-Rodriguez, J. J., Llibre-Guerra, J. J., Valhuerdi-Cepero, A. J., Lipton, R. B., Katz, M. J., Zammit, A., Ritchie, K., Carles, S., Carriere, I., Scarmeas, N., …Sachdev, P. (2020). Education and the moderating roles of age, sex, ethnicity and apolipoprotein epsilon 4 on the risk of cognitive impairment. Archives of Gerontology and Geriatrics, 91, Article 104112. https://doi.org/10.1016/j.archger.2020.104112

Background: We examined how the relationship between education and latelife cognitive impairment (defined as a Mini Mental State Examination score below 24) is influenced by age, sex, ethnicity, and Apolipoprotein E epsilon 4 (APOE*4). Methods: Parti... Read More about Education and the moderating roles of age, sex, ethnicity and apolipoprotein epsilon 4 on the risk of cognitive impairment.

Twenty-seven-year time trends in dementia incidence in Europe and the United States: The Alzheimer Cohorts Consortium (2020)
Journal Article
Wolters, F. J., Chibnik, L. B., Waziry, R., Anderson, R., Berr, C., Beiser, A., Bis, J. C., Blacker, D., Bos, D., Brayne, C., Dartigues, J. F., Darweesh, S. K., Davis-Plourde, K. L., De Wolf, F., Debette, S., Dufouil, C., Fornage, M., Goudsmit, J., Grasset, L., Gudnason, V., …Hofman, A. (2020). Twenty-seven-year time trends in dementia incidence in Europe and the United States: The Alzheimer Cohorts Consortium. Neurology, 95(5), E519-E531. https://doi.org/10.1212/WNL.0000000000010022

Objective To determine changes in the incidence of dementia between 1988 and 2015.MethodsThis analysis was performed in aggregated data from individuals >65 years of age in 7 population-based cohort studies in the United States and Europe from the Al... Read More about Twenty-seven-year time trends in dementia incidence in Europe and the United States: The Alzheimer Cohorts Consortium.

Anticholinergic drugs and incident dementia, mild cognitive impairment and cognitive decline: A meta-analysis (2020)
Journal Article
Pieper, N. T., Grossi, C. M., Chan, W. Y., Loke, Y. K., Savva, G. M., Haroulis, C., Steel, N., Fox, C., Maidment, I. D., Arthur, A. J., Myint, P. K., Smith, T. O., Robinson, L., Matthews, F. E., Brayne, C., & Richardson, K. (2020). Anticholinergic drugs and incident dementia, mild cognitive impairment and cognitive decline: A meta-analysis. Age and ageing, 49(6), 939-947. https://doi.org/10.1093/ageing/afaa090

Background: the long-term effect of the use of drugs with anticholinergic activity on cognitive function remains unclear. Methods: we conducted a systematic review and meta-analysis of the relationship between anticholinergic drugs and risk of dement... Read More about Anticholinergic drugs and incident dementia, mild cognitive impairment and cognitive decline: A meta-analysis.

The COVID-19 pandemic and health inequalities (2020)
Journal Article
Bambra, C., Riordan, R., Ford, J., & Matthews, F. (2020). The COVID-19 pandemic and health inequalities. Journal of Epidemiology and Community Health, 74(11), 964-968. https://doi.org/10.1136/jech-2020-214401

This essay examines the implications of the COVID-19 pandemic for health inequalities. It outlines historical and contemporary evidence of inequalities in pandemics - drawing on international research into the Spanish influenza pandemic of 1918, the... Read More about The COVID-19 pandemic and health inequalities.

APOE ε4 and the influence of sex, age, vascular risk factors, and ethnicity on cognitive decline (2020)
Journal Article
Makkar, S. R., Lipnicki, D. M., Crawford, J. D., Kochan, N. A., Castro-Costa, E., Lima-Costa, M. F., Diniz, B. S., Brayne, C., Stephan, B., Matthews, F., Llibre-Rodriguez, J. J., Llibre-Guerra, J. J., Valhuerdi-Cepero, A. J., Lipton, R. B., Katz, M. J., CuilingWang, Ritchie, K., Carles, S., Carriere, I., Scarmeas, N., …Sachdev, P. (2020). APOE ε4 and the influence of sex, age, vascular risk factors, and ethnicity on cognitive decline. The journals of gerontology. Series A, Biological sciences and medical sciences, 75(10), 1863-1873. https://doi.org/10.1093/gerona/glaa116

We aimed to examine the relationship between Apolipoprotein E ε4 (APOE*4) carriage on cognitive decline, and whether these associations were moderated by sex, baseline age, ethnicity, and vascular risk factors. Participants were 19,225 individuals ag... Read More about APOE ε4 and the influence of sex, age, vascular risk factors, and ethnicity on cognitive decline.

Prospective predictors of decline v. stability in mild cognitive impairment with Lewy bodies or Alzheimer's disease (2020)
Journal Article
Hamilton, C. A., Matthews, F. E., Donaghy, P. C., Taylor, J. P., O'Brien, J. T., Barnett, N., …Thomas, A. J. (2021). Prospective predictors of decline v. stability in mild cognitive impairment with Lewy bodies or Alzheimer's disease. Psychological Medicine, 51(15), 2590-2598. https://doi.org/10.1017/S0033291720001130

Background Mild cognitive impairment (MCI) may gradually worsen to dementia, but often remains stable for extended periods of time. Little is known about the predictors of decline to help explain this variation. We aimed to explore whether this heter... Read More about Prospective predictors of decline v. stability in mild cognitive impairment with Lewy bodies or Alzheimer's disease.

Prevalence and determinants of loneliness in people living with dementia: Findings from the IDEAL programme (2020)
Journal Article
Victor, C. R., Rippon, I., Nelis, S. M., Martyr, A., Litherland, R., Pickett, J., Hart, N., Henley, J., Matthews, F., & Clare, L. (2020). Prevalence and determinants of loneliness in people living with dementia: Findings from the IDEAL programme. International journal of geriatric psychiatry, 35(8), 851-858. https://doi.org/10.1002/gps.5305

Objective: To establish the prevalence and determinants of loneliness among people living with dementia. Methods: Using data from the baseline wave of the Improving the experience of Dementia and Enhancing Active Life (IDEAL) cohort study, we examine... Read More about Prevalence and determinants of loneliness in people living with dementia: Findings from the IDEAL programme.

Noradrenergic-dependent functions are associated with age-related locus coeruleus signal intensity differences (2020)
Journal Article
Liu, K. Y., Kievit, R. A., Tsvetanov, K. A., Betts, M. J., Düzel, E., Rowe, J. B., Tyler, L. K., Brayne, C., Bullmore, E. T., Calder, A. C., Cusack, R., Dalgleish, T., Duncan, J., Henson, R. N., Matthews, F. E., Marslen-Wilson, W. D., Shafto, M. A., Campbell, K., Cheung, T., Davis, S., …Hämmerer, D. (2020). Noradrenergic-dependent functions are associated with age-related locus coeruleus signal intensity differences. Nature communications, 11(1), Article 1712. https://doi.org/10.1038/s41467-020-15410-w

The locus coeruleus (LC), the origin of noradrenergic modulation of cognitive and behavioral function, may play an important role healthy ageing and in neurodegenerative conditions. We investigated the functional significance of age-related differenc... Read More about Noradrenergic-dependent functions are associated with age-related locus coeruleus signal intensity differences.

Age-related reduction in motor adaptation: brain structural correlates and the role of explicit memory (2020)
Journal Article
Wolpe, N., Ingram, J. N., Tsvetanov, K. A., Henson, R. N., Wolpert, D. M., Tyler, L. K., Brayne, C., Bullmore, E. T., Calder, A. C., Cusack, R., Dalgleish, T., Duncan, J., Matthews, F. E., Marslen-Wilson, W. D., Shafto, M. A., Campbell, K., Cheung, T., Davis, S., Geerligs, L., Kievit, R., …Rowe, J. B. (2020). Age-related reduction in motor adaptation: brain structural correlates and the role of explicit memory. Neurobiology of Aging, 90, 13-23. https://doi.org/10.1016/j.neurobiolaging.2020.02.016

The adaption of movement to changes in the environment varies across life span. Recent evidence has linked motor adaptation and its reduction with age to differences in “explicit” learning processes. We examine differences in brain structure and cogn... Read More about Age-related reduction in motor adaptation: brain structural correlates and the role of explicit memory.

Factors associated with self- And informant ratings of quality of life,well-being and life satisfaction in people with mild-to-moderate dementia: Results from the improving the experience of dementia and enhancing active life programme (2020)
Journal Article
Wu, Y. T., Nelis, S. M., Quinn, C., Martyr, A., Jones, I. R., Victor, C. R., Knapp, M., Henderson, C., Hindle, J. V., Jones, R. W., Kopelman, M. D., Morris, R. G., Pickett, J. A., Rusted, J. M., Thom, J. M., Litherland, R., Matthews, F. E., & Clare, L. (2020). Factors associated with self- And informant ratings of quality of life,well-being and life satisfaction in people with mild-to-moderate dementia: Results from the improving the experience of dementia and enhancing active life programme. Age and ageing, 49(3), 446-452. https://doi.org/10.1093/ageing/afz177

Background: A large number of studies have explored factors related to self- and informant ratings of quality of life in people with dementia, but many studies have had relatively small sample sizes and mainly focused on health conditions and dementi... Read More about Factors associated with self- And informant ratings of quality of life,well-being and life satisfaction in people with mild-to-moderate dementia: Results from the improving the experience of dementia and enhancing active life programme.

Dementia Research Fit for the Planet: Reflections on Population Studies of Dementia for Researchers and Policy Makers Alike (2020)
Journal Article
Brayne, C. E., Barnes, L. E., Breteler, M. M., Brooks, R. L., Dufouil, C., Fox, C., Fratiglioni, L., Ikram, M. A., Kenny, R. A., Kivipelto, M., Lobo, A., Musicco, M., Qiu, C., Richard, E., Riedel-Heller, S. G., Ritchie, C., Skoog, I., Stephan, B. C., Venneri, A., & Matthews, F. E. (2020). Dementia Research Fit for the Planet: Reflections on Population Studies of Dementia for Researchers and Policy Makers Alike. Neuroepidemiology, 54(2), 157-170. https://doi.org/10.1159/000505626

In recent years, a rapidly increasing collection of investigative methods in addition to changes in diagnostic criteria for dementia have followed "high-tech" trends in medicine, with the aim to better define the dementia syndrome and its biological... Read More about Dementia Research Fit for the Planet: Reflections on Population Studies of Dementia for Researchers and Policy Makers Alike.

Neuropathological Correlates of Cumulative Benzodiazepine and Anticholinergic Drug Use (2020)
Journal Article
Richardson, K., Wharton, S. B., Grossi, C. M., Matthews, F. E., Fox, C., Maidment, I., Loke, Y. K., Steel, N., Arthur, A., Myint, P. K., Boustani, M., Campbell, N., Robinson, L., Brayne, C., & Savva, G. M. (2020). Neuropathological Correlates of Cumulative Benzodiazepine and Anticholinergic Drug Use. Journal of Alzheimer's Disease, 74(3), 999-1009. https://doi.org/10.3233/JAD-191199

Background: Benzodiazepines and anticholinergic drugs have been implicated in causing cognitive decline and potentially increasing dementia risk. However, evidence for an association with neuropathology is limited. Objective: To estimate the correlat... Read More about Neuropathological Correlates of Cumulative Benzodiazepine and Anticholinergic Drug Use.

Living Alone with Mild-To-Moderate Dementia: Findings from the IDEAL Cohort (2020)
Journal Article
Clare, L., Martyr, A., Henderson, C., Gamble, L., Matthews, F. E., Quinn, C., Nelis, S. M., Rusted, J., Thom, J., Knapp, M., Hart, N., & Victor, C. (2020). Living Alone with Mild-To-Moderate Dementia: Findings from the IDEAL Cohort. Journal of Alzheimer's Disease, 78(3), 1207-1216. https://doi.org/10.3233/JAD-200638

Background: A significant proportion of people with dementia live alone, but little is known about their specific needs. Objective: To understand the profile of people living alone with mild-to-moderate dementia in the UK and identify any systematic... Read More about Living Alone with Mild-To-Moderate Dementia: Findings from the IDEAL Cohort.

NDRG2 expression correlates with neurofibrillary tangles and microglial pathology in the ageing brain (2020)
Journal Article
Fadul, M. M., Garwood, C. J., Waller, R., Garrett, N., Heath, P. R., Matthews, F. E., Brayne, C., Wharton, S. B., & Simpson, J. E. (2020). NDRG2 expression correlates with neurofibrillary tangles and microglial pathology in the ageing brain. International Journal of Molecular Sciences, 21(1), Article 340. https://doi.org/10.3390/ijms21010340

Astrocytes play a major role in the pathogenesis of a range of neurodegenerative diseases, including Alzheimer’s disease (AD), undergoing dramatic morphological and molecular changes that can cause potentially both beneficial and detrimental effects.... Read More about NDRG2 expression correlates with neurofibrillary tangles and microglial pathology in the ageing brain.

Population levels of mild cognitive impairment in England and Wales (2019)
Book Chapter
Fleming, J., Matthews, F. E., Chatfield, M., & Brayne, C. (2020). Population levels of mild cognitive impairment in England and Wales. In H. A. Tuokko, & D. F. Hultsch (Eds.), Mild Cognitive Impairment: International Perspectives (77-91). New York: Psychology Press. https://doi.org/10.4324/9781003020301

Cognitive changes have been shown to be strongly age-related, but the boundary between normal ageing and cognitive decline is less clear. Several approaches to the examination of ageing and cognition have emerged over the last few decades, all of whi... Read More about Population levels of mild cognitive impairment in England and Wales.

Epidemiological pathology of Aβ deposition in the ageing brain in CFAS: addition of multiple Aβ-derived measures does not improve dementia assessment using logistic regression and machine learning approaches (2019)
Journal Article
Wharton, S. B., Wang, D., Parikh, C., Matthews, F. E., Brayne, C., & Ince, P. G. (2019). Epidemiological pathology of Aβ deposition in the ageing brain in CFAS: addition of multiple Aβ-derived measures does not improve dementia assessment using logistic regression and machine learning approaches. Acta Neuropathologica Communications, 7(1), 198. https://doi.org/10.1186/s40478-019-0858-4

Aβ-amyloid deposition is a key feature of Alzheimer's disease, but Consortium to Establish a Registry for Alzheimer's Disease (CERAD) assessment, based on neuritic plaque density, shows a limited relationships to dementia. Thal phase is based on a ne... Read More about Epidemiological pathology of Aβ deposition in the ageing brain in CFAS: addition of multiple Aβ-derived measures does not improve dementia assessment using logistic regression and machine learning approaches.

Recruitment and methodological issues in conducting dementia research in British ethnic minorities: A qualitative systematic review (2019)
Journal Article
Waheed, W., Mirza, N., Waheed, M. W., Blakemore, A., Kenning, C., Masood, Y., Matthews, F., & Bower, P. (2020). Recruitment and methodological issues in conducting dementia research in British ethnic minorities: A qualitative systematic review. International Journal of Methods in Psychiatric Research, 29(1), Article e1806. https://doi.org/10.1002/mpr.1806

Objective: Identifying existing recruitment and methodological issues within dementia research conducted in UK studies that included ethnic minorities. Methods: We searched for and included any publication detailing dementia research in the UK that i... Read More about Recruitment and methodological issues in conducting dementia research in British ethnic minorities: A qualitative systematic review.

Social isolation, cognitive reserve, and cognition in older people with depression and anxiety (2019)
Journal Article
Evans, I. E., Llewellyn, D. J., Matthews, F. E., Woods, R. T., Brayne, C., & Clare, L. (2019). Social isolation, cognitive reserve, and cognition in older people with depression and anxiety. Aging and Mental Health, 23(12), 1691-1700. https://doi.org/10.1080/13607863.2018.1506742

Objectives: Poor social connections may be associated with poor cognition in older people who are not experiencing mental health problems, and the trajectory of this association may be moderated by cognitive reserve. However, it is unclear whether th... Read More about Social isolation, cognitive reserve, and cognition in older people with depression and anxiety.

Perceptual and conceptual processing of visual objects across the adult lifespan (2019)
Journal Article
Bruffaerts, R., Tyler, L. K., Shafto, M., Tsvetanov, K. A., Brayne, C., Bullmore, E. T., …Clarke, A. (2019). Perceptual and conceptual processing of visual objects across the adult lifespan. Scientific reports, 9(1), https://doi.org/10.1038/s41598-019-50254-5

Making sense of the external world is vital for multiple domains of cognition, and so it is crucial that object recognition is maintained across the lifespan. We investigated age differences in perceptual and conceptual processing of visual objects i... Read More about Perceptual and conceptual processing of visual objects across the adult lifespan.