All Outputs (334)

Dementia: Time trends and policy responses (2014)
Journal Article
Wu, Y. T., Matthews, F. E., & Brayne, C. (2014). Dementia: Time trends and policy responses. Maturitas, 79(2), 191-195. https://doi.org/10.1016/j.maturitas.2014.06.020

In recent years, dementia has been considered a public health priority and become a topic of major political interest. Recent reviews and studies have reported with varying degrees of alarm an impending and existing "dementia epidemic" with increasin... Read More about Dementia: Time trends and policy responses.

TDP-43 pathology in the population: Prevalence and associations with dementia and age (2014)
Journal Article
Keage, H. A., Hunter, S., Matthews, F. E., Ince, P. G., Hodges, J., Hokkanen, S. R., …Brayne, C. (2014). TDP-43 pathology in the population: Prevalence and associations with dementia and age. Journal of Alzheimer's Disease, 42(2), 641-650. https://doi.org/10.3233/JAD-132351

Objective: We aimed to determine the prevalence of transactive response DNA-binding protein of 43 kDA (TDP-43) neuronal inclusions in a population-based sample, and associations with age group at death (≤90 and >90 years) and clinical dementia status... Read More about TDP-43 pathology in the population: Prevalence and associations with dementia and age.

The Mandarin Childhood Autism Spectrum Test (CAST): Sex differences (2014)
Journal Article
Sun, X., Allison, C., Auyeung, B., Matthews, F. E., Sharp, S. J., Baron-Cohen, S., & Brayne, C. (2014). The Mandarin Childhood Autism Spectrum Test (CAST): Sex differences. Journal of Autism and Developmental Disorders, 44(9), 2137-2146. https://doi.org/10.1007/s10803-014-2088-8

Sex differences in social and communication behaviours related to autism spectrum conditions (ASC) have been investigated mainly in Western populations. Little research has been done in Chinese populations. This study explored sex differences related... Read More about The Mandarin Childhood Autism Spectrum Test (CAST): Sex differences.

Drivers of inequality in disability-free expectancy at birth and age 85 across space and time in Great Britain (2014)
Journal Article
Wohland, P., Rees, P., Gillies, C., Alvanides, S., Matthews, F. E., O'Neill, V., & Jagger, C. (2014). Drivers of inequality in disability-free expectancy at birth and age 85 across space and time in Great Britain. Journal of Epidemiology and Community Health, 68(9), 826-833. https://doi.org/10.1136/jech-2014-204083

Background: Although mortality and health inequalities at birth have increased both geographically and in socioeconomic terms, little is known about inequalities at age 85, the fastest growing sector of the population in Great Britain (GB). Aim To de... Read More about Drivers of inequality in disability-free expectancy at birth and age 85 across space and time in Great Britain.

Potential for primary prevention of Alzheimer's disease: An analysis of population-based data (2014)
Journal Article
Norton, S., Matthews, F. E., Barnes, D. E., Yaffe, K., & Brayne, C. (2014). Potential for primary prevention of Alzheimer's disease: An analysis of population-based data. Lancet Neurology, 13(8), 788-794. https://doi.org/10.1016/S1474-4422%2814%2970136-X

Background: Recent estimates suggesting that over half of Alzheimer's disease burden worldwide might be attributed to potentially modifiable risk factors do not take into account risk-factor non-independence. We aimed to provide specific estimates of... Read More about Potential for primary prevention of Alzheimer's disease: An analysis of population-based data.

Psychometric properties of the Mandarin version of the Childhood Autism Spectrum Test (CAST): An exploratory study (2014)
Journal Article
Sun, X., Allison, C., Auyeung, B., Matthews, F. E., Norton, S., Baron-Cohen, S., & Brayne, C. (2014). Psychometric properties of the Mandarin version of the Childhood Autism Spectrum Test (CAST): An exploratory study. Journal of Autism and Developmental Disorders, 44(7), 1565-1576. https://doi.org/10.1007/s10803-013-2024-3

Limited studies have investigated the latent autistic traits in the mainland Chinese population for autism spectrum conditions (ASC). This study explored the psychometric properties of a Mandarin Chinese version of the CAST in a sample consisting of... Read More about Psychometric properties of the Mandarin version of the Childhood Autism Spectrum Test (CAST): An exploratory study.

Investigating healthy life expectancy using a multi-state model in the presence of missing data and misclassification (2014)
Journal Article
van den Hout, A., Ogurtsova, E., Gampe, J., & Matthews, F. E. (2014). Investigating healthy life expectancy using a multi-state model in the presence of missing data and misclassification. https://doi.org/10.4054/DemRes.2014.30.42

Background: A continuous-time three-state model can be used to describe change in cognitive function in the older population. State 1 corresponds to normal cognitive function, state 2 to cognitive impairment, and state 3 to dead. For statistical infe... Read More about Investigating healthy life expectancy using a multi-state model in the presence of missing data and misclassification.

Cognitive lifestyle jointly predicts longitudinal cognitive decline and mortality risk (2014)
Journal Article
Marioni, R. E., Proust-Lima, C., Amieva, H., Brayne, C., Matthews, F. E., Dartigues, J. F., & Jacqmin-Gadda, H. (2014). Cognitive lifestyle jointly predicts longitudinal cognitive decline and mortality risk. European Journal of Epidemiology, 29(3), 211-219. https://doi.org/10.1007/s10654-014-9881-8

Cognitive lifestyle measures such as education, occupation, and social engagement are commonly associated with late-life cognitive ability although their associations with cognitive decline tend to be mixed. However, longitudinal analyses of cognitio... Read More about Cognitive lifestyle jointly predicts longitudinal cognitive decline and mortality risk.

Grouping of behavioural and psychological symptoms of dementia (2014)
Journal Article
Van Der Linde, R. M., Dening, T., Matthews, F. E., & Brayne, C. (2014). Grouping of behavioural and psychological symptoms of dementia. International journal of geriatric psychiatry, 29(6), 562-568. https://doi.org/10.1002/gps.4037

Objective A wide range of behavioural and psychological symptoms (BPSD) are common in dementia, and it has been suggested that groups of correlated symptoms should be studied together. Here, we describe the groups of BPSD that have been identified in... Read More about Grouping of behavioural and psychological symptoms of dementia.

Comparison between a Mandarin Chinese version of the Childhood Autism Spectrum Test and the Clancy Autism Behaviour Scale in mainland China (2014)
Journal Article
Sun, X., Allison, C., Auyeung, B., Matthews, F. E., Zhang, Z., Baron-Cohen, S., & Brayne, C. (2014). Comparison between a Mandarin Chinese version of the Childhood Autism Spectrum Test and the Clancy Autism Behaviour Scale in mainland China. Research in Developmental Disabilities, 35(7), 1599-1608. https://doi.org/10.1016/j.ridd.2014.02.005

A Mandarin Chinese version of the Childhood Autism Spectrum Test (CAST) and Clancy Autism Behaviour Scale (CABS) were applied to 150 children aged 4-11 years old from clinical settings and mainstream schools in Beijing. All the children were further... Read More about Comparison between a Mandarin Chinese version of the Childhood Autism Spectrum Test and the Clancy Autism Behaviour Scale in mainland China.

Brain haemosiderin in older people: Pathological evidence for an ischaemic origin of magnetic resonance imaging (MRI) microbleeds (2014)
Journal Article
Janaway, B. M., Simpson, J. E., Hoggard, N., Highley, J. R., Forster, G., Drew, D., …Ince, P. G. (2014). Brain haemosiderin in older people: Pathological evidence for an ischaemic origin of magnetic resonance imaging (MRI) microbleeds. Neuropathology and Applied Neurobiology, 40(3), 258-269. https://doi.org/10.1111/nan.12062

Introduction: Magnetic resonance imaging (MRI) cerebral microbleeds (CMB) arise from ferromagnetic haemosiderin iron assumed to derive from extravasation of erythrocytes. Light microscopy of ageing brain frequently reveals foci of haemosiderin from s... Read More about Brain haemosiderin in older people: Pathological evidence for an ischaemic origin of magnetic resonance imaging (MRI) microbleeds.

Education associated with a delayed onset of terminal decline (2014)
Journal Article
Terrera, G. M., Minett, T., Brayne, C., & Matthews, F. E. (2014). Education associated with a delayed onset of terminal decline. Age and ageing, 43(1), 26-31. https://doi.org/10.1093/ageing/aft150

Background: the terminal decline hypothesis suggests an acceleration in the rate of loss of cognitive function before death. Evidence about the association of educational attainment and the onset of terminal decline is scarce. Objective: to investiga... Read More about Education associated with a delayed onset of terminal decline.

Service provision for autism in mainland China: Preliminary mapping of service pathways (2013)
Journal Article
Sun, X., Allison, C., Auyeung, B., Matthews, F. E., Baron-Cohen, S., & Brayne, C. (2013). Service provision for autism in mainland China: Preliminary mapping of service pathways. Social science & medicine, 98, 87-94. https://doi.org/10.1016/j.socscimed.2013.08.016

Few data on healthcare services for individuals with Autism Spectrum Conditions (ASC) are available from mainland China. This article is based on findings from 69 semi-structured interviews with parents of children with ASC in three intervention cent... Read More about Service provision for autism in mainland China: Preliminary mapping of service pathways.

Calcium dysregulation in relation to Alzheimer-type pathology in the ageing brain (2013)
Journal Article
Garwood, C., Faizullabhoy, A., Wharton, S. B., Ince, P. G., Heath, P. R., Shaw, P. J., …Simpson, J. E. (2013). Calcium dysregulation in relation to Alzheimer-type pathology in the ageing brain. Neuropathology and Applied Neurobiology, 39(7), 788-799. https://doi.org/10.1111/nan.12033

Aims: Calcium dyshomeostasis is implicated in the pathogenesis of several neurodegenerative disorders including Alzheimer's disease. However, much of the previous research has focused on changes in neuronal calcium signalling. In a recent microarray... Read More about Calcium dysregulation in relation to Alzheimer-type pathology in the ageing brain.

COSMIC (Cohort Studies of Memory in an International Consortium): An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups (2013)
Journal Article
Sachdev, P. S., Lipnicki, D. M., Kochan, N. A., Crawford, J. D., Rockwood, K., Xiao, S., …Santabárbara, J. (2013). COSMIC (Cohort Studies of Memory in an International Consortium): An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups. BMC Neurology, 13, https://doi.org/10.1186/1471-2377-13-165

Background: A large number of longitudinal studies of population-based ageing cohorts are in progress internationally, but the insights from these studies into the risk and protective factors for cognitive ageing and conditions like mild cognitive im... Read More about COSMIC (Cohort Studies of Memory in an International Consortium): An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups.

The Mandarin Chinese version of the childhood autism spectrum test (CAST): Test-retest reliability (2013)
Journal Article
Sun, X., Allison, C., Auyeung, B., Matthews, F. E., Baron-Cohen, S., & Brayne, C. (2013). The Mandarin Chinese version of the childhood autism spectrum test (CAST): Test-retest reliability. Research in Developmental Disabilities, 34(10), 3267-3275. https://doi.org/10.1016/j.ridd.2013.05.042

This study aimed to investigate the test-retest reliability of a Mandarin Chinese version of the Childhood Autism Spectrum Test (CAST), in a Chinese population. Parents in a school based study on the prevalence of ASC in mainland China were asked to... Read More about The Mandarin Chinese version of the childhood autism spectrum test (CAST): Test-retest reliability.

Predicting risk of 2-year incident dementia using the camcog total and subscale scores (2013)
Journal Article
Restaino, M., Matthews, F. E., Minett, T., Albanese, E., Brayne, C., & Stephan, B. C. M. (2013). Predicting risk of 2-year incident dementia using the camcog total and subscale scores. Age and ageing, 42(5), 649-653. https://doi.org/10.1093/ageing/aft082

Background: being able to identify individuals at high risk of dementia is important for diagnostics and intervention. Currently, there is no standard approach to assessing cognitive function in older aged individuals to best predict incident dementi... Read More about Predicting risk of 2-year incident dementia using the camcog total and subscale scores.

Investigating terminal decline: Results from a UK population-based study of aging (2013)
Journal Article
Muniz-Terrera, G., van den Hout, A., Piccinin, A. M., Matthews, F. E., & Hofer, S. M. (2013). Investigating terminal decline: Results from a UK population-based study of aging. Psychology and Aging, 28(2), 377-385. https://doi.org/10.1037/a0031000

The terminal decline hypothesis states that in the proximity of death, an individual's decline in cognitive abilities accelerates. We aimed at estimating the onset of faster rate of decline in global cognition using Mini Mental State Examination (MMS... Read More about Investigating terminal decline: Results from a UK population-based study of aging.

The presence of behavioural and psychological symptoms and progression to dementia in the cognitively impaired older population (2013)
Journal Article
Van Der Linde, R. M., Stephan, B. C., Matthews, F. E., Brayne, C., & Savva, G. M. (2013). The presence of behavioural and psychological symptoms and progression to dementia in the cognitively impaired older population. International journal of geriatric psychiatry, 28(7), 700-709. https://doi.org/10.1002/gps.3873

Objective Behavioural and psychological symptoms (BPS) are common in the older population and may be an indication of early dementia. We explored the predictive effect of the presence of BPS on the 2-year progression to dementia in a cognitively impa... Read More about The presence of behavioural and psychological symptoms and progression to dementia in the cognitively impaired older population.

Prevalence Studies of Dementia in Mainland China, Hong Kong and Taiwan: A Systematic Review and Meta-Analysis (2013)
Journal Article
Wu, Y. T., Lee, H. Y., Norton, S., Chen, C., Chen, H., He, C., …Brayne, C. (2013). Prevalence Studies of Dementia in Mainland China, Hong Kong and Taiwan: A Systematic Review and Meta-Analysis. PLoS ONE, 8(6), https://doi.org/10.1371/journal.pone.0066252

Background:Many studies have considered the prevalence of dementia in mainland China, Hong Kong and Taiwan. However, area level estimates have not been produced. This study examines area differences across mainland China, Hong Kong and Taiwan adjusti... Read More about Prevalence Studies of Dementia in Mainland China, Hong Kong and Taiwan: A Systematic Review and Meta-Analysis.