All Outputs (6)

The effect of genetic structure on molecular dating and tests for temporal signal (2015)
Journal Article
Murray, G. G., Wang, F., Harrison, E. M., Paterson, G. K., Mather, A. E., Harris, S. R., Holmes, M. A., Rambaut, A., & Welch, J. J. (2016). The effect of genetic structure on molecular dating and tests for temporal signal. Methods in ecology and evolution British Ecological Society, 7(1), 80-89. https://doi.org/10.1111/2041-210x.12466

© 2016 British Ecological Society. 'Dated-tip' methods of molecular dating use DNA sequences sampled at different times, to estimate the age of their most recent common ancestor. Several tests of 'temporal signal' are available to determine whether d... Read More about The effect of genetic structure on molecular dating and tests for temporal signal.

Old drugs to treat resistant bugs: Methicillin-resistant Staphylococcus aureus isolates with mecC are susceptible to a combination of penicillin and clavulanic acid (2015)
Journal Article
Ba, X., Harrison, E. M., Lovering, A. L., Gleadall, N., Zadoks, R., Parkhill, J., Peacock, S. J., Holden, M. T. G., Paterson, G. K., & Holmes, M. A. (2015). Old drugs to treat resistant bugs: Methicillin-resistant Staphylococcus aureus isolates with mecC are susceptible to a combination of penicillin and clavulanic acid. Antimicrobial agents and chemotherapy, 59(12), 7396-7404. https://doi.org/10.1128/AAC.01469-15

β-Lactam resistance in methicillin-resistant Staphylococcus aureus (MRSA) is mediated by the expression of an alternative penicillin-binding protein 2a (PBP2a) (encoded by mecA) with a low affinity for β-lactam antibiotics. Recently, a novel variant... Read More about Old drugs to treat resistant bugs: Methicillin-resistant Staphylococcus aureus isolates with mecC are susceptible to a combination of penicillin and clavulanic acid.

Draft genome sequence of the Streptococcus pneumoniae Avery strain A66 (2015)
Journal Article
Hahn, C., Harrison, E. M., Parkhill, J., Holmes, M. A., & Paterson, G. K. (2018). Draft genome sequence of the Streptococcus pneumoniae Avery strain A66. Genome announcements, 3(3), Article e00697-15. https://doi.org/10.1128/genomeA.00697-15

We have used HiSeq 2000 technology to generate a draft genome sequence of Streptococcus pneumoniae strain A66. This is a common study strain used in investigations of pneumococcal bacterium-host interactions and was used in the seminal genetic studie... Read More about Draft genome sequence of the Streptococcus pneumoniae Avery strain A66.

Detection of livestock-associated meticillin-resistant Staphylococcus aureus CC398 in retail pork, United Kingdom, February 2015 (2015)
Journal Article
Hadjirin, N., Lay, E., Paterson, G., Harrison, E., Peacock, S., Parkhill, J., Zadoks, R., & Holmes, M. (2015). Detection of livestock-associated meticillin-resistant Staphylococcus aureus CC398 in retail pork, United Kingdom, February 2015. Euro surveillance bulletin européen sur les maladies transmissibles = European communicable disease bulletin, 20(24), 21156. https://doi.org/10.2807/1560-7917.es2015.20.24.21156

Livestock-associated meticillin-resistant Staphylococcus aureus belonging to clonal complex 398 (LA-MRSA CC398) is an important cause of zoonotic infections in many countries. Here, we describe the isolation of LA-MRSA CC398 from retail meat samples... Read More about Detection of livestock-associated meticillin-resistant Staphylococcus aureus CC398 in retail pork, United Kingdom, February 2015.

Mechanisms of methicillin resistance in Staphylococcus aureus (2015)
Journal Article
Peacock, S. J., & Paterson, G. K. (2015). Mechanisms of methicillin resistance in Staphylococcus aureus. Annual review of biochemistry, 84(1), 577-601. https://doi.org/10.1146/annurev-biochem-060614-034516

Staphylococcus aureus is a major human and veterinary pathogen worldwide. Methicillin-resistant S. aureus (MRSA) poses a significant and enduring problem to the treatment of infection by such strains. Resistance is usually conferred by the acquisitio... Read More about Mechanisms of methicillin resistance in Staphylococcus aureus.

Capturing the cloud of diversity reveals complexity and heterogeneity of MRSA carriage, infection and transmission (2015)
Journal Article
Paterson, G. K., Harrison, E. M., Murray, G. G. R., Welch, J. J., Warland, J. H., Holden, M. T. G., Morgan, F. J. E., Ba, X., Koop, G., Harris, S. R., Maskell, D. J., Peacock, S. J., Herrtage, M. E., Parkhill, J., & Holmes, M. A. (2015). Capturing the cloud of diversity reveals complexity and heterogeneity of MRSA carriage, infection and transmission. Nature communications, 6(1), https://doi.org/10.1038/ncomms7560

Genome sequencing is revolutionizing clinical microbiology and our understanding of infectious diseases. Previous studies have largely relied on the sequencing of a single isolate from each individual. However, it is not clear what degree of bacteria... Read More about Capturing the cloud of diversity reveals complexity and heterogeneity of MRSA carriage, infection and transmission.