All Outputs (5)

Amino acids and the early mammalian embryo: Origin, fate, function and life‐long legacy (2021)
Journal Article
Leese, H. J., McKeegan, P., & Sturmey, R. G. (2021). Amino acids and the early mammalian embryo: Origin, fate, function and life‐long legacy. International Journal of Environmental Research and Public Health, 18(18), Article 9874. https://doi.org/10.3390/ijerph18189874

Amino acids are now recognised as having multiple cellular functions in addition to their traditional role as constituents of proteins. This is well-illustrated in the early mammalian embryo where amino acids are now known to be involved in intermedi... Read More about Amino acids and the early mammalian embryo: Origin, fate, function and life‐long legacy.

Application of extracellular flux analysis for determining mitochondrial function in mammalian oocytes and early embryos (2019)
Journal Article
Muller, B., Lewis, N., Adeniyi, T., Leese, H. J., Brison, D. R., & Sturmey, R. G. (2019). Application of extracellular flux analysis for determining mitochondrial function in mammalian oocytes and early embryos. Scientific reports, 9(1), Article 16778. https://doi.org/10.1038/s41598-019-53066-9

Mitochondria provide the major source of ATP for mammalian oocyte maturation and early embryo development. Oxygen Consumption Rate (OCR) is an established measure of mitochondrial function. OCR by mammalian oocytes and embryos has generally been rest... Read More about Application of extracellular flux analysis for determining mitochondrial function in mammalian oocytes and early embryos.

Application of extracellular flux analysis for determining mitochondrial function in mammalian oocytes and early embryos (2019)
Preprint / Working Paper
Muller, B., Lewis, N., Adeniyi, T., Leese, H. J., Brison, D., & Sturmey, R. G. Application of extracellular flux analysis for determining mitochondrial function in mammalian oocytes and early embryos

Background Mitochondria provide the major source of ATP for mammalian oocyte maturation and early embryo development. Oxygen Consumption Rate (OCR) is an established measure of mitochondrial function. OCR by mammalian oocytes and embryos has generall... Read More about Application of extracellular flux analysis for determining mitochondrial function in mammalian oocytes and early embryos.

Expression and function of transient receptor potential channels in the female bovine reproductive tract (2016)
Journal Article
Ghavideldarestani, M., Atkin, S. L., Leese, H. J., & Sturmey, R. G. (2016). Expression and function of transient receptor potential channels in the female bovine reproductive tract. Theriogenology, 86(2), 551-561. https://doi.org/10.1016/j.theriogenology.2016.02.005

© 2016 Elsevier Inc. The epithelium lining the oviduct is critical for early reproductive events, many of which are mediated via intracellular calcium ions. Despite this, little is known about the regulation of calcium homeostasis in the oviductal ep... Read More about Expression and function of transient receptor potential channels in the female bovine reproductive tract.

Human embryos from overweight and obese women display phenotypic and metabolic abnormalities (2014)
Journal Article
Leary, C., Leese, H. J., & Sturmey, R. G. (2015). Human embryos from overweight and obese women display phenotypic and metabolic abnormalities. Human Reproduction, 30(1), 122-132. https://doi.org/10.1093/humrep/deu276

STUDY QUESTION Is the developmental timing and metabolic regulation disrupted in embryos from overweight or obese women? SUMMARY ANSWER Oocytes from overweight or obese women are smaller than those from women of healthy weight, yet post-fertilization... Read More about Human embryos from overweight and obese women display phenotypic and metabolic abnormalities.