All Outputs (4)

Anticancer properties of Thymbra capitata and Helichrysum italicum essential oils (2014)
Presentation / Conference Contribution
Juliana, P., Marco, L., Célia, C., Lígia, S., & Pires, I. M. D. S. (2014, July). Anticancer properties of Thymbra capitata and Helichrysum italicum essential oils. Presented at IMMR | International Meeting on Marine Research 2014, Peniche, Portugal

An essential oil (EO) is defined internationally as the product obtained by hydrodistillation, of a plant or some parts of it. They are aromatic oily liquids, volatile, characterized by a strong odour, rarely coloured, and generally with a lower dens... Read More about Anticancer properties of Thymbra capitata and Helichrysum italicum essential oils.

Assessment of the properties of the essential oil from Ridolfia segetum Moris (Portugal) on cancer cell viability (2014)
Presentation / Conference Contribution
Poças, J., Lemos, M., Cabral, C., Cavaleiro, C., Cruz, M., Salgueiro, L., & Pires, I. (2014, August). Assessment of the properties of the essential oil from Ridolfia segetum Moris (Portugal) on cancer cell viability. Presented at 62nd International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, Guimarães, Portugal

Ridolfia segetum Moris, commonly known as corn parsley, false fennel, or false caraway, is distributed throughout the Mediterranean region. It belongs to the Apiaceae (carrot or parsley family), which includes well-known aromatic and medicinal plants... Read More about Assessment of the properties of the essential oil from Ridolfia segetum Moris (Portugal) on cancer cell viability.

RASSF1A–LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2 (2014)
Journal Article
Pefani, D.-E., Latusek, R., Pires, I., Grawenda, A. M., Yee, K. S., Hamilton, G., van der Weyden, L., Esashi, F., Hammond, E. M., & O'Neill, E. (2014). RASSF1A–LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2. Nature Cell Biology, 16(10), 962-971. https://doi.org/10.1038/ncb3035

Genomic instability is a key hallmark of cancer leading to tumour heterogeneity and therapeutic resistance. ​BRCA2 has a fundamental role in error-free DNA repair but also sustains genome integrity by promoting ​RAD51 nucleofilament formation at stal... Read More about RASSF1A–LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2.

HIF-1 alpha-independent hypoxia-induced rapid PTK6 stabilization is associated with increased motility and invasion (2014)
Journal Article
Poujade, F.-A., Harvey, A. J., Blokland, N. J. G., Broos, A. W. T., Eccles, S. A., Hammond, E. M., Pires, I. M., Senra, J. M., & Span, P. N. (2014). HIF-1 alpha-independent hypoxia-induced rapid PTK6 stabilization is associated with increased motility and invasion. Cancer Biology and Therapy, 15(10), 1350-1357. https://doi.org/10.4161/cbt.29822

© 2014 Landes Bioscience. PTK6/Brk is a non-receptor tyrosine kinase overexpressed in cancer. Here we demonstrate that cytosolic PTK6 is rapidly and robustly induced in response to hypoxic conditions in a HIF-1-independent manner. Furthermore, a prop... Read More about HIF-1 alpha-independent hypoxia-induced rapid PTK6 stabilization is associated with increased motility and invasion.