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Assessment of the properties of the essential oil from Ridolfia segetum Moris (Portugal) on cancer cell viability

Poças, J; Lemos, M; Cabral, C; Cavaleiro, C; Cruz, MT; Salgueiro, L; Pires, I

Authors

J Poças

M Lemos

C Cabral

C Cavaleiro

MT Cruz

L Salgueiro

I Pires



Abstract

Ridolfia segetum Moris, commonly known as corn parsley, false fennel, or false caraway, is distributed throughout the Mediterranean region. It belongs to the Apiaceae (carrot or parsley family), which includes well-known aromatic and medicinal plants with characteristic hollow stems. R. segetum is used in traditional medicine to prevent constipation, coughing and respiratory tract infections. The present work aimed to characterize the chemical composition of the essential oil obtained from the flowering aerial parts of R. segetum collected in Portugal, as well as to evaluate its citotoxic activity, specifically looking at the effect on viability of human colorectal cancer (RKO) and breast cancer (MCF7) cell lines. The essential oils characterization was addressed by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) and the assessment of cell viability was made by the MTS assay. The main compounds of the oil are α-phellandrene (63.3%) and terpinolene (11.9%). The essential oil, at final concentration of 1µL/mL, lead to a decrease in cell viability for both RKO (colorectal) and MCF7 (breast) cancer cell lines. IC50 values were 7.34E-02 µL/mL and 3.33E-02 µL/mL, for RKO and MCF7 cell lines, respectively. This study shows that R. segetum essential oil decreases RKO and MCF7 cell viability. However, further research is necessary in order to clarify the cellular and molecular mechanisms behind the observed effects, and consequently, any potential anticancer therapeutic applications.

Citation

Poças, J., Lemos, M., Cabral, C., Cavaleiro, C., Cruz, M., Salgueiro, L., & Pires, I. (2014). Assessment of the properties of the essential oil from Ridolfia segetum Moris (Portugal) on cancer cell viability. . https://doi.org/10.1055/s-0034-1394701

Conference Name 62nd International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research
Conference Location Guimarães, Portugal
Start Date Aug 31, 2014
End Date Sep 4, 2014
Acceptance Date Jul 1, 2014
Online Publication Date Oct 30, 2014
Publication Date 2014
Deposit Date Jun 29, 2020
Publisher Georg Thieme Verlag
Volume 80, issue 16 (Book of Abstracts)
Series Title Planta Medica
Series ISSN 0032-0943
DOI https://doi.org/10.1055/s-0034-1394701
Keywords Ridolfia segetum, Essential oil, Anticancer properties
Public URL https://hull-repository.worktribe.com/output/3531539