Assessment of the properties of the essential oil from Ridolfia segetum Moris (Portugal) on cancer cell viability

Poças, J; Lemos, M; Cabral, C; Cavaleiro, C; Cruz, MT; Salgueiro, L; Pires, I

Abstract

Ridolfia segetum Moris, commonly known as corn parsley, false fennel, or false caraway, is distributed throughout the Mediterranean region. It belongs to the Apiaceae (carrot or parsley family), which includes well-known aromatic and medicinal plants with characteristic hollow stems. R. segetum is used in traditional medicine to prevent constipation, coughing and respiratory tract infections. The present work aimed to characterize the chemical composition of the essential oil obtained from the flowering aerial parts of R. segetum collected in Portugal, as well as to evaluate its citotoxic activity, specifically looking at the effect on viability of human colorectal cancer (RKO) and breast cancer (MCF7) cell lines. The essential oils characterization was addressed by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) and the assessment of cell viability was made by the MTS assay. The main compounds of the oil are α-phellandrene (63.3%) and terpinolene (11.9%). The essential oil, at final concentration of 1µL/mL, lead to a decrease in cell viability for both RKO (colorectal) and MCF7 (breast) cancer cell lines. IC50 values were 7.34E-02 µL/mL and 3.33E-02 µL/mL, for RKO and MCF7 cell lines, respectively. This study shows that R. segetum essential oil decreases RKO and MCF7 cell viability. However, further research is necessary in order to clarify the cellular and molecular mechanisms behind the observed effects, and consequently, any potential anticancer therapeutic applications.

Citation

Poças, J., Lemos, M., Cabral, C., Cavaleiro, C., Cruz, M., Salgueiro, L., & Pires, I. (2014, August). Assessment of the properties of the essential oil from Ridolfia segetum Moris (Portugal) on cancer cell viability. Presented at 62nd International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, Guimarães, Portugal

• Presentation Conference Type: Conference Paper (published)
• Conference Name: 62nd International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research
• Start Date: Aug 31, 2014
• End Date: Sep 4, 2014
• Acceptance Date: Jul 1, 2014
• Online Publication Date: Oct 30, 2014
• Publication Date: 2014
• Deposit Date: Jun 29, 2020
• Publisher: Georg Thieme Verlag
• Volume: 80, issue 16 (Book of Abstracts)
• Series Title: Planta Medica
• Series ISSN: 0032-0943
• DOI: https://doi.org/10.1055/s-0034-1394701
• Keywords: Ridolfia segetum, Essential oil, Anticancer properties
• Public URL: https://hull-repository.worktribe.com/output/3531539