A novel population health approach: using fish retinoblastoma gene profiles as a surrogate for humans
(2008)
Journal Article
Rotchell, J. M., du Corbier, F. A., Stentiford, G. D., Lyons, B. P., Liddle, A. R., & Ostrander, G. K. (2009). A novel population health approach: using fish retinoblastoma gene profiles as a surrogate for humans. Comparative Biochemistry and Physiology - Part C: Toxicology and Pharmacology, 149(2), 134-140. https://doi.org/10.1016/j.cbpc.2008.09.009
Retinoblastoma, a tumor suppressor gene, is frequently mutated in diverse types of human tumors. We have previously shown that two types of fish tumor, eye and liver, also possess mutant Rb genes. Our aim is to determine if the Rb allele status is li... Read More about A novel population health approach: using fish retinoblastoma gene profiles as a surrogate for humans.