Ligation of anti-cancer drugs to self-assembling ultrashort peptides by click chemistry for localized therapy
(2013)
Journal Article
Reithofer, M. R., Chan, K.-H., Lakshmanan, A., Lam, D. H., Mishra, A., Gopalan, B., …Hauser, C. A. E. (2014). Ligation of anti-cancer drugs to self-assembling ultrashort peptides by click chemistry for localized therapy. Chemical science, 5(2), 625-630. https://doi.org/10.1039/c3sc51930a
Self-assembling ultrashort peptides from aliphatic amino acids were functionalized with platinum anti-cancer drugs by click chemistry. Oxaliplatin-derived hybrid peptide hydrogels with up to 40% drug loading were tested for localized breast cancer th... Read More about Ligation of anti-cancer drugs to self-assembling ultrashort peptides by click chemistry for localized therapy.